Professor | Chunlai Chen | Asia Growth Partners

Name	Chunlai Chen
Contact Information	chunlai@tsinghua.edu.cn
Language ability	Chinese, English
Province	Beijing

Name

Chunlai Chen

Contact Information

chunlai@tsinghua.edu.cn

Language ability

Chinese, English

Province

Beijing

University/Lab Affiliation and Title	Tsinghua University
Faculty	Life Sciences
Academic Background & Achievements	1999-2003 Bachelor: Peking University, School of Chemistry and Molecular Engineering 2003-2008 PhD: Peking University, School of Chemistry and Molecular Engineering
Work Experience	2008-2015 - University of Pennsylvania - Postdoctoral Researcher 2015-2018 - Tsinghua University, School of Life Sciences - Assistant Professor 2018-present - Tsinghua University, School of Life Sciences - Associate Professor

University/Lab Affiliation and Title

Tsinghua University

Faculty

Life Sciences

Academic Background & Achievements

1999-2003 Bachelor: Peking University, School of Chemistry and Molecular Engineering
2003-2008 PhD: Peking University, School of Chemistry and Molecular Engineering

Work Experience

2008-2015 - University of Pennsylvania - Postdoctoral Researcher
2015-2018 - Tsinghua University, School of Life Sciences - Assistant Professor
2018-present - Tsinghua University, School of Life Sciences - Associate Professor

Areas of Focus	Development of novel single-molecule fluorescence techniques Study of protein targeting mechanisms on DNA Research on targeting and cleavage mechanisms of CRISPR-related proteins
Publications	General strategy to improve the photon budget of thiol-conjugated cyanine dyes, Chunlai Chen et al., 2023 Nonspecific interactions between Cas12a and dsDNA located downstream of the PAM mediate target search and assist AsCas12a for DNA cleavage, Chunlai Chen et al., 2023 Structural and dynamic mechanisms for coupled folding and tRNA recognition of a translational T-box riboswitch, Chunlai Chen et al., 2023 Function and dynamics of the intrinsically disordered carboxyl terminus of β2 adrenergic receptor, Chunlai Chen et al., 2023 Mechanisms of distinctive mismatch tolerance between Rad51 and Dmc1 in homologous recombination, Chunlai Chen et al., 2021 Pseudoknot length modulates the folding, conformational dynamics and robustness of Xrn1 resistance of flaviviral xrRNAs, Chunlai Chen et al., 2021 Nonspecific interactions between SpCas9 and dsDNA sites located downstream of the PAM mediate facilitated diffusion to accelerate target search, Chunlai Chen et al., 2021 Single-molecule FRET and conformational analysis of beta-arrestin-1 through genetic code expansion and a Se-click reaction, Chunlai Chen et al., 2021 Phase separation at the nanoscale quantified by dcFCCS, Chunlai Chen et al., 2020 Target search and recognition mechanisms of glycosylase AlkD revealed by scanning FRET-FCS and Markov State Models, Chunlai Chen et al., 2020

Areas of Focus

Development of novel single-molecule fluorescence techniques
Study of protein targeting mechanisms on DNA
Research on targeting and cleavage mechanisms of CRISPR-related proteins

Publications

General strategy to improve the photon budget of thiol-conjugated cyanine dyes, Chunlai Chen et al., 2023
Nonspecific interactions between Cas12a and dsDNA located downstream of the PAM mediate target search and assist AsCas12a for DNA cleavage, Chunlai Chen et al., 2023
Structural and dynamic mechanisms for coupled folding and tRNA recognition of a translational T-box riboswitch, Chunlai Chen et al., 2023
Function and dynamics of the intrinsically disordered carboxyl terminus of β2 adrenergic receptor, Chunlai Chen et al., 2023
Mechanisms of distinctive mismatch tolerance between Rad51 and Dmc1 in homologous recombination, Chunlai Chen et al., 2021
Pseudoknot length modulates the folding, conformational dynamics and robustness of Xrn1 resistance of flaviviral xrRNAs, Chunlai Chen et al., 2021
Nonspecific interactions between SpCas9 and dsDNA sites located downstream of the PAM mediate facilitated diffusion to accelerate target search, Chunlai Chen et al., 2021
Single-molecule FRET and conformational analysis of beta-arrestin-1 through genetic code expansion and a Se-click reaction, Chunlai Chen et al., 2021
Phase separation at the nanoscale quantified by dcFCCS, Chunlai Chen et al., 2020
Target search and recognition mechanisms of glycosylase AlkD revealed by scanning FRET-FCS and Markov State Models, Chunlai Chen et al., 2020

Fluorescence Single-Molecule Techniques Protein Dna Targeting Mechanisms Crispr Cleavage Research

Chunlai Chen - Tsinghua University

Zhong-Lin Zhang - Shanghai Normal University

Chengqi Yi - Peking University

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