Professor | Zhixin Wang | Asia Growth Partners

Name	Zhixin Wang
Contact Information	zhixinwang@mail.tsinghua.edu.cn
Language ability	Chinese, English
Province	Beijing

Name

Zhixin Wang

Contact Information

zhixinwang@mail.tsinghua.edu.cn

Language ability

Chinese, English

Province

Beijing

University/Lab Affiliation and Title	Tsinghua University
Faculty	Life Sciences
Academic Background & Achievements	1973-1977: Bachelor in Chemistry and Chemical Engineering, Tsinghua University 1982-1988: PhD in Biophysics, Chinese Academy of Sciences
Work Experience	1977-1981: Teaching Assistant, Department of Chemistry and Chemical Engineering, Tsinghua University 1988-1989: Associate Researcher, Institute of Biophysics, Chinese Academy of Sciences 1989-1991: Postdoctoral Fellow, Department of Chemistry, Cornell University 1991-1993: Research Assistant, Department of Biochemistry, North Dakota State University 1993-2003: Researcher, Institute of Biophysics, Chinese Academy of Sciences 1995-1999: Deputy Director, Institute of Biophysics, Chinese Academy of Sciences 1999-2003: Director, Institute of Biophysics, Chinese Academy of Sciences 1997-2003: Director, National Laboratory of Biomacromolecules, Beijing 2003-present: Professor, School of Life Sciences, Tsinghua University
Awards	1990: First Prize, Natural Science Award, Chinese Academy of Sciences 1993: Second Prize, National Natural Science Award 1993: First Prize, Young Scientist Award, Chinese Academy of Sciences 1994: Young Scientist Award, China 1997: Elected Academician, Chinese Academy of Sciences 1999: Elected Academician, The World Academy of Sciences

University/Lab Affiliation and Title

Tsinghua University

Faculty

Life Sciences

Academic Background & Achievements

1973-1977: Bachelor in Chemistry and Chemical Engineering, Tsinghua University
1982-1988: PhD in Biophysics, Chinese Academy of Sciences

Work Experience

1977-1981: Teaching Assistant, Department of Chemistry and Chemical Engineering, Tsinghua University
1988-1989: Associate Researcher, Institute of Biophysics, Chinese Academy of Sciences
1989-1991: Postdoctoral Fellow, Department of Chemistry, Cornell University
1991-1993: Research Assistant, Department of Biochemistry, North Dakota State University
1993-2003: Researcher, Institute of Biophysics, Chinese Academy of Sciences
1995-1999: Deputy Director, Institute of Biophysics, Chinese Academy of Sciences
1999-2003: Director, Institute of Biophysics, Chinese Academy of Sciences
1997-2003: Director, National Laboratory of Biomacromolecules, Beijing
2003-present: Professor, School of Life Sciences, Tsinghua University

Awards

1990: First Prize, Natural Science Award, Chinese Academy of Sciences
1993: Second Prize, National Natural Science Award
1993: First Prize, Young Scientist Award, Chinese Academy of Sciences
1994: Young Scientist Award, China
1997: Elected Academician, Chinese Academy of Sciences
1999: Elected Academician, The World Academy of Sciences

Areas of Focus	Molecular Enzymology Bioinformatics
Publications	Mechanistic studies of the autoactivation of PAK2: a two-step model of cis initiation followed by trans amplification, Wang J, Wu JW, Wang ZX, 2011 Enzymatic activity and substrate specificity of mitogen-activated protein kinase p38alpha in different phosphorylation states, Zhang YY, Mei ZQ, Wu JW, Wang ZX, 2008 The complete pathway for ERK2-catalyzed reaction. Evidence for an iso random Bi-Bi mechanism, Wang ZX, Wu JW., 2007 Kinetic analysis of ligand-induced autocatalytic reactions, Liu JH and Wang ZX, 2004 The mechanism of p21-activated protein kinase 2 autoactivation, Wu H and Wang ZX, 2003 Cooperative autoinhibition and multi-level activation mechanisms of calcineurin, Li SJ, Wang J, Ma L, Lu C, Wang J, Wu JW, Wang ZX, 2016 A conserved motif in JNK/p38-specific MAPK phosphatases as a determinant for JNK1 recognition and inactivation, Liu X, Zhang CS, Lu C, Lin SC, Wu JW, Wang ZX, 2016 Structural insights into the negative regulation of BRI1 signaling by BRI1-interacting protein BKI1, Wang J, Jiang J, Wang J, Chen L, Fan SL, Wu JW, Wang X, Wang ZX, 2014 Structural Insights into the Autoactivation Mechanism of p21-Activated Protein Kinase, Wang J, Wu JW, Wang ZX, 2011 A distinct interaction mode revealed by the crystal structure of the Kinase p38 with the MAPK binding domain of the Phosphatase MKP5, Zhang YY, Wu JW, Wang ZX, 2011 MAP kinase phosphatase 3-mediated crosstalk between MAP kinases ERK2 and p38α, Zhang YY, Wu JW, Wang ZX*, 2011

Areas of Focus

Molecular Enzymology
Bioinformatics

Publications

Mechanistic studies of the autoactivation of PAK2: a two-step model of cis initiation followed by trans amplification, Wang J, Wu JW, Wang ZX*, 2011
Enzymatic activity and substrate specificity of mitogen-activated protein kinase p38alpha in different phosphorylation states, Zhang YY, Mei ZQ, Wu JW*, Wang ZX*, 2008
The complete pathway for ERK2-catalyzed reaction. Evidence for an iso random Bi-Bi mechanism, Wang ZX*, Wu JW.*, 2007
Kinetic analysis of ligand-induced autocatalytic reactions, Liu JH and Wang ZX*, 2004
The mechanism of p21-activated protein kinase 2 autoactivation, Wu H and Wang ZX*, 2003
Cooperative autoinhibition and multi-level activation mechanisms of calcineurin, Li SJ, Wang J, Ma L, Lu C, Wang J, Wu JW*, Wang ZX*, 2016
A conserved motif in JNK/p38-specific MAPK phosphatases as a determinant for JNK1 recognition and inactivation, Liu X, Zhang CS, Lu C, Lin SC, Wu JW*, Wang ZX*, 2016
Structural insights into the negative regulation of BRI1 signaling by BRI1-interacting protein BKI1, Wang J, Jiang J, Wang J, Chen L, Fan SL, Wu JW, Wang X, Wang ZX*, 2014
Structural Insights into the Autoactivation Mechanism of p21-Activated Protein Kinase, Wang J, Wu JW, Wang ZX*, 2011
A distinct interaction mode revealed by the crystal structure of the Kinase p38 with the MAPK binding domain of the Phosphatase MKP5, Zhang YY, Wu JW, Wang ZX*, 2011
MAP kinase phosphatase 3-mediated crosstalk between MAP kinases ERK2 and p38α, Zhang YY, Wu JW, Wang ZX*, 2011

Enzymes Catalysis Protein Structure Molecular Biology Genetics Computational Biology Data Analysis Protein Engineering Signal Transduction Molecular Modeling Genomics Proteomics Data Mining Machine Learning Computational Models Sequence Analysis Database Management Systems Biology Algorithm Development Statistical Analysis

Yong Zhang - Tongji University

Yanping Zhang - Tongji University

Guohui Chuai - Tongji University

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