Areas of Focus
- 分子酶学
- 生物信息学
Work Experience
- 1977-1981: 清华大学化学与化学工程系，助教
- 1988-1989: 中国科学院生物物理研究所，副研究员
- 1989-1991: 美国康乃尔大学化学系，博士后
- 1991-1993: 美国北达哥他州立大学生物化学系，研究助理
- 1993-2003: 中国科学院生物物理研究所，研究员
- 1995-1999: 中国科学院生物物理研究所，副所长
- 1999-2003: 中国科学院生物物理研究所，所长
- 1997-2003: 北京生物大分子国家重点实验室，主任
- 2003-至今: 清华大学生命科学学院，教授
Academic Background & Achievements
- 1973-1977: 清华大学化学与化学工程系，学士
- 1982-1988: 中国科学院生物物理研究所，理学博士
Publications
- Mechanistic studies of the autoactivation of PAK2: a two-step model of cis initiation followed by trans amplification, Wang J, Wu JW, Wang ZX*, 2011
- Enzymatic activity and substrate specificity of mitogen-activated protein kinase p38alpha in different phosphorylation states, Zhang YY, Mei ZQ, Wu JW*, Wang ZX*, 2008
- The complete pathway for ERK2-catalyzed reaction. Evidence for an iso random Bi-Bi mechanism, Wang ZX*, Wu JW.*, 2007
- Kinetic analysis of ligand-induced autocatalytic reactions, Liu JH and Wang ZX*, 2004
- The mechanism of p21-activated protein kinase 2 autoactivation, Wu H and Wang ZX*, 2003
- Cooperative autoinhibition and multi-level activation mechanisms of calcineurin, Li SJ, Wang J, Ma L, Lu C, Wang J, Wu JW*, Wang ZX*, 2016
- A conserved motif in JNK/p38-specific MAPK phosphatases as a determinant for JNK1 recognition and inactivation, Liu X, Zhang CS, Lu C, Lin SC, Wu JW*, Wang ZX*, 2016
- Structural insights into the negative regulation of BRI1 signaling by BRI1-interacting protein BKI1, Wang J, Jiang J, Wang J, Chen L, Fan SL, Wu JW, Wang X, Wang ZX*, 2014
- Structural Insights into the Autoactivation Mechanism of p21-Activated Protein Kinase, Wang J, Wu JW, Wang ZX*, 2011
- A distinct interaction mode revealed by the crystal structure of the Kinase p38 with the MAPK binding domain of the Phosphatase MKP5, Zhang YY, Wu JW, Wang ZX*, 2011
- MAP kinase phosphatase 3-mediated crosstalk between MAP kinases ERK2 and p38α, Zhang YY, Wu JW, Wang ZX*, 2011
Awards
- 1990年: 中国科学院自然科学奖一等奖
- 1993年: 国家自然科学奖二等奖
- 1993年: 中国科学院青年科学家奖一等奖
- 1994年: 中国青年科学家奖
- 1997年: 当选中国科学院院士
- 1999年: 当选第三世界科学院院士
