Professor | Songhai Shi | Asia Growth Partners

Name	Songhai Shi
Contact Information	shisonghai@mail.tsinghua.edu.cn
Language ability	English, Chinese
Province	Beijing

Name

Songhai Shi

Contact Information

shisonghai@mail.tsinghua.edu.cn

Language ability

English, Chinese

Province

Beijing

University/Lab Affiliation and Title	Tsinghua University
Faculty	Life Sciences
Academic Background & Achievements	1991-1996 Bachelor: Tsinghua University, Department of Biological Sciences and Technology 1996-2001 PhD in Genetics: Cold Spring Harbor Laboratory & Stony Brook University, NY 2001-2006 Postdoctoral Research: University of California, San Francisco & Howard Hughes Medical Institute
Work Experience	2006-2019 - Memorial Sloan-Kettering Cancer Center, USA - Assistant Researcher/Associate Researcher/Researcher 2006-2019 - Weill Cornell Medical College, USA - Assistant Professor/Associate Professor/Professor 2019-present - Tsinghua University School of Life Sciences & Tsinghua University-IDG/McGovern Institute for Brain Science - Professor & Dean
Awards	Breakthrough of the Year, Runner-up, Science (1999) Amersham Biosciences and Science Prize for Young Scientists, Grand Prize (2001) Helen Hay Whitney Foundation Fellowship (2002) Klingenstein Award (2007) NARSAD Young Investigator Award (2008) McKnight Scholar Award (2010) Blavatnik Awards for Young Scientists (2010) The Vilcek Prize for Creative Promise in Biomedical Science, Finalist (2012) Howard Hughes Medical Institute (HHMI) Faculty Scholar Award (2016) Beijing Outstanding Young Scientist (2019)

University/Lab Affiliation and Title

Tsinghua University

Faculty

Life Sciences

Academic Background & Achievements

1991-1996 Bachelor: Tsinghua University, Department of Biological Sciences and Technology
1996-2001 PhD in Genetics: Cold Spring Harbor Laboratory & Stony Brook University, NY
2001-2006 Postdoctoral Research: University of California, San Francisco & Howard Hughes Medical Institute

Work Experience

2006-2019 - Memorial Sloan-Kettering Cancer Center, USA - Assistant Researcher/Associate Researcher/Researcher
2006-2019 - Weill Cornell Medical College, USA - Assistant Professor/Associate Professor/Professor
2019-present - Tsinghua University School of Life Sciences & Tsinghua University-IDG/McGovern Institute for Brain Science - Professor & Dean

Awards

Breakthrough of the Year, Runner-up, Science (1999)
Amersham Biosciences and Science Prize for Young Scientists, Grand Prize (2001)
Helen Hay Whitney Foundation Fellowship (2002)
Klingenstein Award (2007)
NARSAD Young Investigator Award (2008)
McKnight Scholar Award (2010)
Blavatnik Awards for Young Scientists (2010)
The Vilcek Prize for Creative Promise in Biomedical Science, Finalist (2012)
Howard Hughes Medical Institute (HHMI) Faculty Scholar Award (2016)
Beijing Outstanding Young Scientist (2019)

Areas of Focus	Neural development and assembly, Regulation of animal behavior and cognition, Neurobiology methods (electrophysiology and imaging), Genetics, Molecular biology, Cell biology, Developmental biology, Neural stem cell regulation, Neural circuit assembly, Pathogenesis of neurodevelopmental and functional diseases
Publications	Specific synapses develop preferentially among sister excitatory neurons in the neocortex, Yu, Y.-C., Bultje, R.S., Wang, X., and Shi, S.-H., 2009 Mammalian Par3 regulates progenitor cell asymmetric division via Notch signaling in the developing neocortex, Bultje, R.S., Castaneda-Castellanos, D.R., Jan, L.Y., Jan, Y.N., Kriegstein, A.R., and Shi, S.-H., 2009 Asymmetric centrosome inheritance maintains neural progenitors in the neocortex, Wang, X., Tsai, J.-W., Imai, J.H., Lin, W.-N., Valle, R.B., and Shi, S.-H., 2009 Clonal Production and Organization of Inhibitory Interneurons in the Neocortex, Brown, K.N., Chen, S., Han, Z., Lu, C.-H., Tan, X., Ding, L., Zhang, X.-J., Cruz, A. L., Saur, D., Anderson, S.A., Huang, K., and Shi, S.-H., 2011 Preferential electric coupling regulates neocortical lineage-dependent microcircuit assembly, Yu, Y.-C., He, S., Chen, S., Fu, Y., Brown, K.N., Yao, X.H., Ma, J., Gao, K.P., Sosinsky, G.E., Huang, K., and Shi, S.-H., 2012 Lineage-dependent structural and functional organization of the hippocampus, Xu, H.-T., Han Z., Gao, P., He, S., Li, Z., Shi, W., Kordish, O., Shao, W., Brown, K.N., Huang, K., and Shi. S-H., 2014 SDCCAG8 regulates pericentriolar material recruitment and neuronal migration in the developing neocortex, Insolera, R., Shao, W., Airik, R., Hildebrandt, F., and Shi, S.-H., 2014 Cortical neurogenesis in the absence of centrioles, Insolera, R., Bazzi, H., W. Shao, Anderson, K.V., and Shi, S.-H., 2014 Deterministic progenitor behavior and unitary production of neurons in the neocortex, Gao, P., Postiglione Pia, M., Krieger, T.G., Hernandez, L., T., Wang, C., Han, Z., Streicher, C., Papusheva, E., Insolera, R., Chugh, K., Kodish, O., Huang, K., Simons, B.D., Luo, L., Hippenmeyer, S., and Shi, S.-H., 2014 Inside-out radial migration facilitates lineage-dependent microcircuit assembly in the neocortex, He, S., Li, Z., Ge, S., Yu, Y.-C., and Shi, S.-H., 2015 Ontogenetic Establishment of Order-specific Nuclear Organization in the Mammalian Thalamus, Shi, W., Xianyu, A., Han, Z., Tang, X., Li, Z., Zhong, H., Mao, T., Huang, K., and Shi, S.-H., 2017 Precise Long-range Microcircuit-to- Microcircuit Communication Connects the Frontal and Sensory Cortices in the Mammalian brain, Ren, S.-Q., Li, Z., Lin, S., Bergami, M., and Shi S.-H., 2019 Centrosome Anchoring Regulates Mechanical Properties of Neural Progenitors and Cortical Formation, Shao, W., Yang, J., Brendel, M., Lee, C.H., Z. Yang, Lin, S., Li, Z., Joyner, A.L., Anderson, K.V., Zhang, J., Tsou, M.-F., Shi, H., and Shi, S.-H., 2020 Metabolic lactate production coordinates vasculature development and progenitor behavior in the developing mouse neocortex, Dong, X., Zhang, Q., Yu, X., Wang, D., Ma, J., Ma, J. and Shi, S.-H., 2022 Patterned cPCDH expression regulates the fine organization of the neocortex, Lv, X., Li, S., Li, J., Yu, X.-Y., Ge, X., Li, B., Hu, S., Lin, Y., Zhang, S., Yang, J., Zhang, X., Yan, J., Joyner, A. L., Shi, H., Wu, Q., and Shi, S.-H., 2022

Areas of Focus

Neural development and assembly, Regulation of animal behavior and cognition, Neurobiology methods (electrophysiology and imaging), Genetics, Molecular biology, Cell biology, Developmental biology, Neural stem cell regulation, Neural circuit assembly, Pathogenesis of neurodevelopmental and functional diseases

Publications

Specific synapses develop preferentially among sister excitatory neurons in the neocortex, Yu, Y.-C., Bultje, R.S., Wang, X., and Shi, S.-H., 2009
Mammalian Par3 regulates progenitor cell asymmetric division via Notch signaling in the developing neocortex, Bultje, R.S., Castaneda-Castellanos, D.R., Jan, L.Y., Jan, Y.N., Kriegstein, A.R., and Shi, S.-H., 2009
Asymmetric centrosome inheritance maintains neural progenitors in the neocortex, Wang, X., Tsai, J.-W., Imai, J.H., Lin, W.-N., Valle, R.B., and Shi, S.-H., 2009
Clonal Production and Organization of Inhibitory Interneurons in the Neocortex, Brown, K.N., Chen, S., Han, Z., Lu, C.-H., Tan, X., Ding, L., Zhang, X.-J., Cruz, A. L., Saur, D., Anderson, S.A., Huang, K., and Shi, S.-H., 2011
Preferential electric coupling regulates neocortical lineage-dependent microcircuit assembly, Yu, Y.-C., He, S., Chen, S., Fu, Y., Brown, K.N., Yao, X.H., Ma, J., Gao, K.P., Sosinsky, G.E., Huang, K., and Shi, S.-H., 2012
Lineage-dependent structural and functional organization of the hippocampus, Xu, H.-T., Han Z., Gao, P., He, S., Li, Z., Shi, W., Kordish, O., Shao, W., Brown, K.N., Huang, K., and Shi. S-H., 2014
SDCCAG8 regulates pericentriolar material recruitment and neuronal migration in the developing neocortex, Insolera, R., Shao, W., Airik, R., Hildebrandt, F., and Shi, S.-H., 2014
Cortical neurogenesis in the absence of centrioles, Insolera, R., Bazzi, H., W. Shao, Anderson, K.V., and Shi, S.-H., 2014
Deterministic progenitor behavior and unitary production of neurons in the neocortex, Gao, P., Postiglione Pia, M., Krieger, T.G., Hernandez, L., T., Wang, C., Han, Z., Streicher, C., Papusheva, E., Insolera, R., Chugh, K., Kodish, O., Huang, K., Simons, B.D., Luo, L., Hippenmeyer, S., and Shi, S.-H., 2014
Inside-out radial migration facilitates lineage-dependent microcircuit assembly in the neocortex, He, S., Li, Z., Ge, S., Yu, Y.-C., and Shi, S.-H., 2015
Ontogenetic Establishment of Order-specific Nuclear Organization in the Mammalian Thalamus, Shi, W., Xianyu, A., Han, Z., Tang, X., Li, Z., Zhong, H., Mao, T., Huang, K., and Shi, S.-H., 2017
Precise Long-range Microcircuit-to- Microcircuit Communication Connects the Frontal and Sensory Cortices in the Mammalian brain, Ren, S.-Q., Li, Z., Lin, S., Bergami, M., and Shi S.-H., 2019
Centrosome Anchoring Regulates Mechanical Properties of Neural Progenitors and Cortical Formation, Shao, W., Yang, J., Brendel, M., Lee, C.H., Z. Yang, Lin, S., Li, Z., Joyner, A.L., Anderson, K.V., Zhang, J., Tsou, M.-F., Shi, H., and Shi, S.-H., 2020
Metabolic lactate production coordinates vasculature development and progenitor behavior in the developing mouse neocortex, Dong, X., Zhang, Q., Yu, X., Wang, D., Ma, J., Ma, J. and Shi, S.-H., 2022
Patterned cPCDH expression regulates the fine organization of the neocortex, Lv, X., Li, S., Li, J., Yu, X.-Y., Ge, X., Li, B., Hu, S., Lin, Y., Zhang, S., Yang, J., Zhang, X., Yan, J., Joyner, A. L., Shi, H., Wu, Q., and Shi, S.-H., 2022

Neural Development Neural Assembly Animal Behavior Cognition Electrophysiology Imaging Genetics Molecular Biology Cell Biology Developmental Biology

Yunfa Ge - Zhejiang University

Shangbang Gao - Huazhong University of Science and Technology

Shi Songhai - Tsinghua University

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