Areas of Focus
- Neural development and assembly, Regulation of animal behavior and cognition, Neurobiology methods (electrophysiology and imaging), Genetics, Molecular biology, Cell biology, Developmental biology, Neural stem cell regulation, Neural circuit assembly, Pathogenesis of neurodevelopmental and functional diseases
Work Experience
- 2006-2019 - Memorial Sloan-Kettering Cancer Center, USA - Assistant Researcher/Associate Researcher/Researcher
- 2006-2019 - Weill Cornell Medical College, USA - Assistant Professor/Associate Professor/Professor
- 2019-present - Tsinghua University School of Life Sciences & Tsinghua University-IDG/McGovern Institute for Brain Science - Professor & Dean
Academic Background & Achievements
- 1991-1996 Bachelor: Tsinghua University, Department of Biological Sciences and Technology
- 1996-2001 PhD in Genetics: Cold Spring Harbor Laboratory & Stony Brook University, NY
- 2001-2006 Postdoctoral Research: University of California, San Francisco & Howard Hughes Medical Institute
Publications
- Specific synapses develop preferentially among sister excitatory neurons in the neocortex, Yu, Y.-C., Bultje, R.S., Wang, X., and Shi, S.-H., 2009
- Mammalian Par3 regulates progenitor cell asymmetric division via Notch signaling in the developing neocortex, Bultje, R.S., Castaneda-Castellanos, D.R., Jan, L.Y., Jan, Y.N., Kriegstein, A.R., and Shi, S.-H., 2009
- Asymmetric centrosome inheritance maintains neural progenitors in the neocortex, Wang, X., Tsai, J.-W., Imai, J.H., Lin, W.-N., Valle, R.B., and Shi, S.-H., 2009
- Clonal Production and Organization of Inhibitory Interneurons in the Neocortex, Brown, K.N., Chen, S., Han, Z., Lu, C.-H., Tan, X., Ding, L., Zhang, X.-J., Cruz, A. L., Saur, D., Anderson, S.A., Huang, K., and Shi, S.-H., 2011
- Preferential electric coupling regulates neocortical lineage-dependent microcircuit assembly, Yu, Y.-C., He, S., Chen, S., Fu, Y., Brown, K.N., Yao, X.H., Ma, J., Gao, K.P., Sosinsky, G.E., Huang, K., and Shi, S.-H., 2012
- Lineage-dependent structural and functional organization of the hippocampus, Xu, H.-T., Han Z., Gao, P., He, S., Li, Z., Shi, W., Kordish, O., Shao, W., Brown, K.N., Huang, K., and Shi. S-H., 2014
- SDCCAG8 regulates pericentriolar material recruitment and neuronal migration in the developing neocortex, Insolera, R., Shao, W., Airik, R., Hildebrandt, F., and Shi, S.-H., 2014
- Cortical neurogenesis in the absence of centrioles, Insolera, R., Bazzi, H., W. Shao, Anderson, K.V., and Shi, S.-H., 2014
- Deterministic progenitor behavior and unitary production of neurons in the neocortex, Gao, P., Postiglione Pia, M., Krieger, T.G., Hernandez, L., T., Wang, C., Han, Z., Streicher, C., Papusheva, E., Insolera, R., Chugh, K., Kodish, O., Huang, K., Simons, B.D., Luo, L., Hippenmeyer, S., and Shi, S.-H., 2014
- Inside-out radial migration facilitates lineage-dependent microcircuit assembly in the neocortex, He, S., Li, Z., Ge, S., Yu, Y.-C., and Shi, S.-H., 2015
- Ontogenetic Establishment of Order-specific Nuclear Organization in the Mammalian Thalamus, Shi, W., Xianyu, A., Han, Z., Tang, X., Li, Z., Zhong, H., Mao, T., Huang, K., and Shi, S.-H., 2017
- Precise Long-range Microcircuit-to- Microcircuit Communication Connects the Frontal and Sensory Cortices in the Mammalian brain, Ren, S.-Q., Li, Z., Lin, S., Bergami, M., and Shi S.-H., 2019
- Centrosome Anchoring Regulates Mechanical Properties of Neural Progenitors and Cortical Formation, Shao, W., Yang, J., Brendel, M., Lee, C.H., Z. Yang, Lin, S., Li, Z., Joyner, A.L., Anderson, K.V., Zhang, J., Tsou, M.-F., Shi, H., and Shi, S.-H., 2020
- Metabolic lactate production coordinates vasculature development and progenitor behavior in the developing mouse neocortex, Dong, X., Zhang, Q., Yu, X., Wang, D., Ma, J., Ma, J. and Shi, S.-H., 2022
- Patterned cPCDH expression regulates the fine organization of the neocortex, Lv, X., Li, S., Li, J., Yu, X.-Y., Ge, X., Li, B., Hu, S., Lin, Y., Zhang, S., Yang, J., Zhang, X., Yan, J., Joyner, A. L., Shi, H., Wu, Q., and Shi, S.-H., 2022
Awards
- Breakthrough of the Year, Runner-up, Science (1999)
- Amersham Biosciences and Science Prize for Young Scientists, Grand Prize (2001)
- Helen Hay Whitney Foundation Fellowship (2002)
- Klingenstein Award (2007)
- NARSAD Young Investigator Award (2008)
- McKnight Scholar Award (2010)
- Blavatnik Awards for Young Scientists (2010)
- The Vilcek Prize for Creative Promise in Biomedical Science, Finalist (2012)
- Howard Hughes Medical Institute (HHMI) Faculty Scholar Award (2016)
- Beijing Outstanding Young Scientist (2019)
