Professor | Yi Lin | Asia Growth Partners

Name	Yi Lin
Contact Information	linyi@mail.tsinghua.edu.cn
Language ability	Chinese, English
Province	Beijing

Name

Yi Lin

Contact Information

linyi@mail.tsinghua.edu.cn

Language ability

Chinese, English

Province

Beijing

University/Lab Affiliation and Title	Tsinghua University
Faculty	Life Sciences
Academic Background & Achievements	2005-2009 Bachelor: Jiangnan University 2009-2014 PhD: Marquette University
Work Experience	2014-2020 - University of Texas Southwestern Medical Center - Postdoctoral Researcher 2020-2023 - Tsinghua University School of Life Sciences - Assistant Professor 2024-present - Tsinghua University School of Life Sciences - Associate Professor 2020-present - Tsinghua-IDG/McGovern Institute for Brain Research, Tsinghua-Peking Joint Center for Life Sciences - Researcher
Awards	Oliver Smith Academic Achievement Award (2013) Marquette University Fellowship (2012-2014) Richard W. Jobling Award (2012-2013)

University/Lab Affiliation and Title

Tsinghua University

Faculty

Life Sciences

Academic Background & Achievements

2005-2009 Bachelor: Jiangnan University
2009-2014 PhD: Marquette University

Work Experience

2014-2020 - University of Texas Southwestern Medical Center - Postdoctoral Researcher
2020-2023 - Tsinghua University School of Life Sciences - Assistant Professor
2024-present - Tsinghua University School of Life Sciences - Associate Professor
2020-present - Tsinghua-IDG/McGovern Institute for Brain Research, Tsinghua-Peking Joint Center for Life Sciences - Researcher

Awards

Oliver Smith Academic Achievement Award (2013)
Marquette University Fellowship (2012-2014)
Richard W. Jobling Award (2012-2013)

Areas of Focus	Phase separation in biomolecules and its implications in neurodegenerative diseases
Publications	Phase separation as a possible mechanism for dosage sensitivity, Liang Yang, Jiali Lyu, Xi Li, Gaigai Guo, Xueya Zhou, Taoyu Chen, Yi Lin, Tingting Li, 2024 Condensation matters, Ke Ruan, Yi Lin, Peiguo Yang, Wen Zhou, 2023 Abnormal phase separation of biomacromolecules in human diseases, Songhao Zhang, Gaofeng Pei, Boya Li, Pilong Li, Yi Lin, 2023 Circadian clocks are modulated by compartmentalized oscillating translation, Yanrong Zhuang, Zhiyuan Li, Shiyue Xiong, Chujie Sun, Boya Li, Shuangcheng Alivia Wu, Jiali Lyu, Xiang Shi, Liang Yang, Yutong Chen, Zhangbin Bao, Xi Li, Chuhanwen Sun, Yuling Chen, Haiteng Deng, Tingting Li, Qingfeng Wu, Ling Qi, Yue Huang, Xuerui Yang, Yi Lin, 2023 The mechanisms to dispose of misfolded proteins in the endoplasmic reticulum of adipocytes, Shuangcheng Alivia Wu, Chenchen Shen, Xiaoqiong Wei, Xiawei Zhang, Siwen Wang, Xinxin Chen, Mauricio Torres, You Lu, Liangguang Leo Lin, Huilun Helen Wang, Allen H Hunter, Deyu Fang, Shengyi Sun, Magdalena I Ivanova, Yi Lin, Ling Qi, 2023 Recruitment of TRIM33 to cell-context specific PML nuclear bodies regulates nodal signaling in mESCs, Hongyao Sun, Yutong Chen, Kun Yan, Yanqiu Shao, Qiangfeng C Zhang, Yi Lin, Qiaoran Xi, 2023 A brief guideline for studies of phase-separated biomolecular condensates, Yifei Gao, Xi Li, Pilong Li, Yi Lin, 2022 Hierarchical deployment of Tbx3 dictates the identity of hypothalamic KNDy neurons to control puberty onset, Xiang Shi, Yanrong Zhuang, Zhenhua Chen, Mingrui Xu, Junqi Kuang, Xue-Lian Sun, Lisen Gao, Xia Kuang, Huairen Zhang, Wei Li, Samuel Zheng Hao Wong, Chuanyu Liu, Longqi Liu, Danhua Jiang, Duanqing Pei, Yi Lin, QingFeng Wu, 2022 Phase separation in RNA biology, Yi Lin, Xiaofeng Fang, 2021 Redox-mediated regulation of an evolutionarily conserved cross-beta structure formed by the TDP43 LC domain, Yi Lin, Xiaoming Zhou, Masato Kato, Daifei Liu, Sina Ghaemmaghami, Benjamin P Tu, Steven L McKnight, 2020 Structure of FUS Protein Fibrils and Its Relevance to Self-Assembly and Phase Separation of Low-Complexity Domains, Dylan T Murray, Masato Kato, Yi Lin, Kent R Thurber, Ivan Hung, Steven L McKnight, Robert Tycko, 2017 Toxic PR Poly-Dipeptides Encoded by the C9orf72 Repeat Expansion Target LC Domain Polymers, Yi Lin, Eiichiro Mori, Masato Kato, Siheng Xiang, Leeju Wu, Ilmin Kwon, Steven L McKnight, 2016

Areas of Focus

Phase separation in biomolecules and its implications in neurodegenerative diseases

Publications

Phase separation as a possible mechanism for dosage sensitivity, Liang Yang, Jiali Lyu, Xi Li, Gaigai Guo, Xueya Zhou, Taoyu Chen, Yi Lin, Tingting Li, 2024
Condensation matters, Ke Ruan, Yi Lin, Peiguo Yang, Wen Zhou, 2023
Abnormal phase separation of biomacromolecules in human diseases, Songhao Zhang, Gaofeng Pei, Boya Li, Pilong Li, Yi Lin, 2023
Circadian clocks are modulated by compartmentalized oscillating translation, Yanrong Zhuang, Zhiyuan Li, Shiyue Xiong, Chujie Sun, Boya Li, Shuangcheng Alivia Wu, Jiali Lyu, Xiang Shi, Liang Yang, Yutong Chen, Zhangbin Bao, Xi Li, Chuhanwen Sun, Yuling Chen, Haiteng Deng, Tingting Li, Qingfeng Wu, Ling Qi, Yue Huang, Xuerui Yang, Yi Lin, 2023
The mechanisms to dispose of misfolded proteins in the endoplasmic reticulum of adipocytes, Shuangcheng Alivia Wu, Chenchen Shen, Xiaoqiong Wei, Xiawei Zhang, Siwen Wang, Xinxin Chen, Mauricio Torres, You Lu, Liangguang Leo Lin, Huilun Helen Wang, Allen H Hunter, Deyu Fang, Shengyi Sun, Magdalena I Ivanova, Yi Lin, Ling Qi, 2023
Recruitment of TRIM33 to cell-context specific PML nuclear bodies regulates nodal signaling in mESCs, Hongyao Sun, Yutong Chen, Kun Yan, Yanqiu Shao, Qiangfeng C Zhang, Yi Lin, Qiaoran Xi, 2023
A brief guideline for studies of phase-separated biomolecular condensates, Yifei Gao, Xi Li, Pilong Li, Yi Lin, 2022
Hierarchical deployment of Tbx3 dictates the identity of hypothalamic KNDy neurons to control puberty onset, Xiang Shi, Yanrong Zhuang, Zhenhua Chen, Mingrui Xu, Junqi Kuang, Xue-Lian Sun, Lisen Gao, Xia Kuang, Huairen Zhang, Wei Li, Samuel Zheng Hao Wong, Chuanyu Liu, Longqi Liu, Danhua Jiang, Duanqing Pei, Yi Lin, QingFeng Wu, 2022
Phase separation in RNA biology, Yi Lin, Xiaofeng Fang, 2021
Redox-mediated regulation of an evolutionarily conserved cross-beta structure formed by the TDP43 LC domain, Yi Lin, Xiaoming Zhou, Masato Kato, Daifei Liu, Sina Ghaemmaghami, Benjamin P Tu, Steven L McKnight, 2020
Structure of FUS Protein Fibrils and Its Relevance to Self-Assembly and Phase Separation of Low-Complexity Domains, Dylan T Murray, Masato Kato, Yi Lin, Kent R Thurber, Ivan Hung, Steven L McKnight, Robert Tycko, 2017
Toxic PR Poly-Dipeptides Encoded by the C9orf72 Repeat Expansion Target LC Domain Polymers, Yi Lin, Eiichiro Mori, Masato Kato, Siheng Xiang, Leeju Wu, Ilmin Kwon, Steven L McKnight, 2016

Phase Separation Biomolecules Neurodegenerative Diseases Cellular Organelles Protein Aggregation Molecular Mechanisms Disease Models Neurobiology Cell Biology Biochemistry

Shaojun Dai - Shanghai Normal University

Fang Yu - Shanghai Normal University

Yonglan Cui - Shanghai Normal University

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