Professor | 吝易 | 数字化转型顾问

Name	吝易
Contact Information	linyi@mail.tsinghua.edu.cn
Language ability	中文, 英语
Province	北京

Name

吝易

Contact Information

linyi@mail.tsinghua.edu.cn

Language ability

中文, 英语

Province

北京

University/Lab Affiliation and Title	清华大学
Faculty	Life Sciences
Academic Background & Achievements	2005-2009 学士：江南大学 2009-2014 博士：马凯特大学
Work Experience	2014-2020 - 得克萨斯大学西南医学中心 - 博士后 2020-2023 - 清华大学生命科学学院 - 助理教授 2024-至今 - 清华大学生命科学学院 - 副教授 2020-至今 - 清华-IDG/麦戈文脑科学研究院、清华-北大生命科学联合中心 - 研究员
Awards	Oliver Smith 学术成就奖 (2013) 马凯特大学奖学金 (2012-2014) Richard W. Jobling 奖 (2012-2013)

University/Lab Affiliation and Title

清华大学

Faculty

Life Sciences

Academic Background & Achievements

2005-2009 学士：江南大学
2009-2014 博士：马凯特大学

Work Experience

2014-2020 - 得克萨斯大学西南医学中心 - 博士后
2020-2023 - 清华大学生命科学学院 - 助理教授
2024-至今 - 清华大学生命科学学院 - 副教授
2020-至今 - 清华-IDG/麦戈文脑科学研究院、清华-北大生命科学联合中心 - 研究员

Awards

Oliver Smith 学术成就奖 (2013)
马凯特大学奖学金 (2012-2014)
Richard W. Jobling 奖 (2012-2013)

Areas of Focus	生物大分子的相分离及其在神经退行性疾病中的应用
Publications	Phase separation as a possible mechanism for dosage sensitivity, Liang Yang, Jiali Lyu, Xi Li, Gaigai Guo, Xueya Zhou, Taoyu Chen, Yi Lin, Tingting Li, 2024 Condensation matters, Ke Ruan, Yi Lin, Peiguo Yang, Wen Zhou, 2023 Abnormal phase separation of biomacromolecules in human diseases, Songhao Zhang, Gaofeng Pei, Boya Li, Pilong Li, Yi Lin, 2023 Circadian clocks are modulated by compartmentalized oscillating translation, Yanrong Zhuang, Zhiyuan Li, Shiyue Xiong, Chujie Sun, Boya Li, Shuangcheng Alivia Wu, Jiali Lyu, Xiang Shi, Liang Yang, Yutong Chen, Zhangbin Bao, Xi Li, Chuhanwen Sun, Yuling Chen, Haiteng Deng, Tingting Li, Qingfeng Wu, Ling Qi, Yue Huang, Xuerui Yang, Yi Lin, 2023 The mechanisms to dispose of misfolded proteins in the endoplasmic reticulum of adipocytes, Shuangcheng Alivia Wu, Chenchen Shen, Xiaoqiong Wei, Xiawei Zhang, Siwen Wang, Xinxin Chen, Mauricio Torres, You Lu, Liangguang Leo Lin, Huilun Helen Wang, Allen H Hunter, Deyu Fang, Shengyi Sun, Magdalena I Ivanova, Yi Lin, Ling Qi, 2023 Recruitment of TRIM33 to cell-context specific PML nuclear bodies regulates nodal signaling in mESCs, Hongyao Sun, Yutong Chen, Kun Yan, Yanqiu Shao, Qiangfeng C Zhang, Yi Lin, Qiaoran Xi, 2023 A brief guideline for studies of phase-separated biomolecular condensates, Yifei Gao, Xi Li, Pilong Li, Yi Lin, 2022 Hierarchical deployment of Tbx3 dictates the identity of hypothalamic KNDy neurons to control puberty onset, Xiang Shi, Yanrong Zhuang, Zhenhua Chen, Mingrui Xu, Junqi Kuang, Xue-Lian Sun, Lisen Gao, Xia Kuang, Huairen Zhang, Wei Li, Samuel Zheng Hao Wong, Chuanyu Liu, Longqi Liu, Danhua Jiang, Duanqing Pei, Yi Lin, QingFeng Wu, 2022 Phase separation in RNA biology, Yi Lin, Xiaofeng Fang, 2021 Redox-mediated regulation of an evolutionarily conserved cross-beta structure formed by the TDP43 LC domain, Yi Lin, Xiaoming Zhou, Masato Kato, Daifei Liu, Sina Ghaemmaghami, Benjamin P Tu, Steven L McKnight, 2020 Structure of FUS Protein Fibrils and Its Relevance to Self-Assembly and Phase Separation of Low-Complexity Domains, Dylan T Murray, Masato Kato, Yi Lin, Kent R Thurber, Ivan Hung, Steven L McKnight, Robert Tycko, 2017 Toxic PR Poly-Dipeptides Encoded by the C9orf72 Repeat Expansion Target LC Domain Polymers, Yi Lin, Eiichiro Mori, Masato Kato, Siheng Xiang, Leeju Wu, Ilmin Kwon, Steven L McKnight, 2016

Areas of Focus

生物大分子的相分离及其在神经退行性疾病中的应用

Publications

Phase separation as a possible mechanism for dosage sensitivity, Liang Yang, Jiali Lyu, Xi Li, Gaigai Guo, Xueya Zhou, Taoyu Chen, Yi Lin, Tingting Li, 2024
Condensation matters, Ke Ruan, Yi Lin, Peiguo Yang, Wen Zhou, 2023
Abnormal phase separation of biomacromolecules in human diseases, Songhao Zhang, Gaofeng Pei, Boya Li, Pilong Li, Yi Lin, 2023
Circadian clocks are modulated by compartmentalized oscillating translation, Yanrong Zhuang, Zhiyuan Li, Shiyue Xiong, Chujie Sun, Boya Li, Shuangcheng Alivia Wu, Jiali Lyu, Xiang Shi, Liang Yang, Yutong Chen, Zhangbin Bao, Xi Li, Chuhanwen Sun, Yuling Chen, Haiteng Deng, Tingting Li, Qingfeng Wu, Ling Qi, Yue Huang, Xuerui Yang, Yi Lin, 2023
The mechanisms to dispose of misfolded proteins in the endoplasmic reticulum of adipocytes, Shuangcheng Alivia Wu, Chenchen Shen, Xiaoqiong Wei, Xiawei Zhang, Siwen Wang, Xinxin Chen, Mauricio Torres, You Lu, Liangguang Leo Lin, Huilun Helen Wang, Allen H Hunter, Deyu Fang, Shengyi Sun, Magdalena I Ivanova, Yi Lin, Ling Qi, 2023
Recruitment of TRIM33 to cell-context specific PML nuclear bodies regulates nodal signaling in mESCs, Hongyao Sun, Yutong Chen, Kun Yan, Yanqiu Shao, Qiangfeng C Zhang, Yi Lin, Qiaoran Xi, 2023
A brief guideline for studies of phase-separated biomolecular condensates, Yifei Gao, Xi Li, Pilong Li, Yi Lin, 2022
Hierarchical deployment of Tbx3 dictates the identity of hypothalamic KNDy neurons to control puberty onset, Xiang Shi, Yanrong Zhuang, Zhenhua Chen, Mingrui Xu, Junqi Kuang, Xue-Lian Sun, Lisen Gao, Xia Kuang, Huairen Zhang, Wei Li, Samuel Zheng Hao Wong, Chuanyu Liu, Longqi Liu, Danhua Jiang, Duanqing Pei, Yi Lin, QingFeng Wu, 2022
Phase separation in RNA biology, Yi Lin, Xiaofeng Fang, 2021
Redox-mediated regulation of an evolutionarily conserved cross-beta structure formed by the TDP43 LC domain, Yi Lin, Xiaoming Zhou, Masato Kato, Daifei Liu, Sina Ghaemmaghami, Benjamin P Tu, Steven L McKnight, 2020
Structure of FUS Protein Fibrils and Its Relevance to Self-Assembly and Phase Separation of Low-Complexity Domains, Dylan T Murray, Masato Kato, Yi Lin, Kent R Thurber, Ivan Hung, Steven L McKnight, Robert Tycko, 2017
Toxic PR Poly-Dipeptides Encoded by the C9orf72 Repeat Expansion Target LC Domain Polymers, Yi Lin, Eiichiro Mori, Masato Kato, Siheng Xiang, Leeju Wu, Ilmin Kwon, Steven L McKnight, 2016

相分离生物大分子神经退行性疾病细胞器蛋白质聚集分子机制疾病模型神经生物学细胞生物学生物化学

康岚 - 同济大学

俞芳 - 上海师范大学

章骏 - 上海师范大学

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