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Kailong Li
Basic Medical Sciences
Peking University
Beijing
Language: Chinese, English
Non-Coding
Regulatory Sequences
Cancer
Metastasis
Chromatin Structure
Development
Cancer Progression
Epigenome Editing
Precision Therapy
Genetic Diseases
Areas of Focus
- Role of non-coding regulatory sequence variations in cancer development and metastasis
- Mechanisms of chromatin three-dimensional structural changes in development and cancer progression
- Applications of epigenome editing systems in precision therapy for rare genetic diseases
Work Experience
- 2015-2021 - University of Texas Southwestern Medical Center, Postdoctoral Research in Jian Xu's lab
- Since June 2021 - Peking University, Associate Research Fellow
Academic Background & Achievements
- 2015 - PhD in Pathology and Pathophysiology: Peking Union Medical College (Tsinghua University Medical Department)
- Published as first/co-first author in prestigious journals
- CPRIT Training Grant (2018, 2019)
Publications
- Genome and epigenome editing identify CCR9 and SLC6A20 as target genes at the 3p21.31 locus associated with severe COVID-19, Yao Y, Ye F, Li K, Xu P, Tan W, Feng Q, Rao S, 2021
- Noncoding Variants Connect Enhancer Dysregulation with Nuclear Receptor Signaling in Hematopoietic Malignancies, Li K, Zhang Y, Liu X, Liu Y, Gu Z, Cao H, Dickerson KE, Chen M, Chen W, Shao Z, Ni M, Xu J, 2020
- Interrogation of enhancer function by enhancer-targeting CRISPR epigenetic editing, Li K, Liu Y, Cao H, Zhang Y, Gu Z, Liu X, Yu A, Kaphle P, Dickerson KE, Ni M, Xu J, 2020
- Dissecting super-enhancer hierarchy based on chromatin interactions, Huang J, Li K, Cai W, Liu X, Zhang Y, Orkin SH, Xu J, Yuan GC, 2018
- In Situ Capture of Chromatin Interactions by Biotinylated dCas9, Liu X, Zhang Y, Chen Y, Li M, Zhou F, Li K, Cao H, Ni M, Liu Y, Gu Z, Dickerson KE, Xie S, Hon GC, Xuan Z, Zhang MQ, Shao Z, Xu J, 2017
- CPS1 maintains pyrimidine pools and DNA synthesis in KRAS/LKB1-mutant lung cancer cells, Kim J, Hu Z, Cai L, Li K, Choi E, Faubert B, Bezwada D, Rodriguez-Canales J, Villalobos P, Lin YF, Ni M, Huffman KE, Girard L, Byers LA, Unsal-Kacmaz K, Peña CG, Heymach JV, Wauters E, Vansteenkiste J, Castrillon DH, Chen BPC, Wistuba I, Lambrechts D, Xu J, Minna JD, DeBerardinis RJ, 2017
Awards
- CPRIT Training Grant (2018, 2019): Grant for cancer research training
- Travel Award for Best Postdoc Poster, Cancer Biology Retreat (2019)
- Collaborator of the Year Award, CRI (2020)
