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Wenhua Yu
yuwenhua@bjmu.edu.cn
Chinese, English
Beijing

Academic Information

Peking University
Basic Medical Sciences
  • 2001-2005, PhD: City University of Hong Kong, Biochemistry
  • Hosted five National Natural Science Foundation projects
  • 1997-2010 - Peking University, Department of Biochemistry and Molecular Biology - Assistant Teacher, Lecturer
  • 2010-Present - Peking University, Department of Biochemistry and Molecular Biology - Associate Professor

Research

Metabolism and tumor development
Epigenetic mechanisms in cancer
Histone deacetylation by SIRT7
Pathophysiological significance in pancreatic and breast cancer
  • PIM1-catalyzed CBX8 phosphorylation promotes the oncogene-induced senescence of human diploid fibroblast, Yu W, 2018
  • Loss of circadian protein TIMELESS accelerates the progression of cellular senescence, Yu W, 2018
  • PIM1 induces cellular senescence through phosphorylation of UHRF1 at Ser311, Yu W, 2017
  • SIRT7 is a histone desuccinylase that functionally links to chromatin compaction and genome stability, Yu W, 2016
  • J Biol Chem, Yu W, 2010
  • Biochim Biophys Acta, Yu W, 2006
  • Arch. Biochem. Biophys., Yu W, 2005
Keywords
Metabolism Tumor Cancer Epigenetics Histone Deacetylation Sirt7 Pancreatic Cancer Breast Cancer Pathophysiology
Related Professors
Shang Yongfeng - Peking University
Area of Focus
Epigenetics | Gene Transcription | Regulation | Breast Cancer | Endometrial Cancer | Molecular Mechanisms | Cancer Development | Transcriptional Complexes | Gene Promoters | Therapeutic Targets
Genze Shao - Peking University
Area of Focus
Brca1 | Tumor Suppressor | Gene | Breast Cancer | Ovarian Cancer | Dna Damage | Cell Cycle | Molecular Mechanisms | Protein Degradation | Cancer Research | Metastasis | K63 Ubiquitination | Chromatin Remodeling | Epigenetics | Rnf8 | Tumor Progression | Molecular Biology | Cancer Therapy | Protein Interactions | Biomarkers | Early Diagnosis | Therapeutic Evaluation | Prognosis | Serum Markers | Tumor Specific | Sensitive Markers | Cancer Detection | Clinical Applications | Molecular Diagnostics | Cell Division | Mitosis | Spindle Assembly | Checkpoint Mechanisms | Protein Ubiquitination | Deubiquitinating Enzymes | Genetic Stability
Chen Fangdong - Zhejiang University
Area of Focus
Metabolism | Emt | Cancer Stem Cells | Tumor Metastasis | Epigenetics | Breast Cancer | Molecular Markers | Gene Research | Functional Genes | Cancer Research
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