Professor | Yu-Xuan Guo | Asia Growth Partners

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Name

Yu-Xuan Guo

Contact Information

guo /AT/ bjmu.edu.cn

Language ability

English, Chinese

Province

Beijing

University/Lab Affiliation and Title	Peking University
Faculty	Basic Medical Sciences
Academic Background & Achievements	2006.9-2010.7 Bachelor: Peking University, School of Life Sciences 2010.8-2015.8 PhD: Johns Hopkins University, Department of Biology
Work Experience	2015.9-2020.11 - Postdoctoral Fellow, Boston Children's Hospital, Harvard Medical School 2020.11-present - Researcher, Peking University Institute of Cardiovascular Research
Awards	2018-2020: American Heart Association Postdoctoral Fellowship 2020: NIH Pathway to Independence Award (K99) 2021-2024: Beijing Science and Technology Rising Star 2022-2024: National Natural Science Foundation of China, Young Scientist Fund 2022-2025: National Natural Science Foundation of China, General Program 2022-2024: Beijing Science and Technology Rising Star Cross Cooperation Project 2022-2027: National Key R&D Program of China, Stem Cell and Organ Repair 2023-2025: National Natural Science Foundation of China, Excellent Young Scientist Fund 2023-2025: Beijing Natural Science Foundation, General Program

University/Lab Affiliation and Title

Peking University

Faculty

Basic Medical Sciences

Academic Background & Achievements

Work Experience

2015.9-2020.11 - Postdoctoral Fellow, Boston Children's Hospital, Harvard Medical School
2020.11-present - Researcher, Peking University Institute of Cardiovascular Research

Awards

2018-2020: American Heart Association Postdoctoral Fellowship
2020: NIH Pathway to Independence Award (K99)
2021-2024: Beijing Science and Technology Rising Star
2022-2024: National Natural Science Foundation of China, Young Scientist Fund
2022-2025: National Natural Science Foundation of China, General Program
2022-2024: Beijing Science and Technology Rising Star Cross Cooperation Project
2022-2027: National Key R&D Program of China, Stem Cell and Organ Repair
2023-2025: National Natural Science Foundation of China, Excellent Young Scientist Fund
2023-2025: Beijing Natural Science Foundation, General Program

Areas of Focus	Cardiomyocyte Development and Pathophysiology Gene Editing and Gene Therapy Stem Cells and Organoid Technology
Publications	Yap1 modulates cardiomyocyte hypertrophy via impaired mitochondrial biogenesis in response to chronic mechanical stress overload, Guo Y, Hua Y, Li Y, 2022 Ryanodine receptor 2 (RYR2) dysfunction activates the unfolded protein response and perturbs cardiomyocyte maturation, Guo Y, Pu WT, 2022 Cas9/AAV9-Mediated Somatic Mutagenesis Uncovered the Cell-Autonomous Role of Sarcoplasmic/Endoplasmic Reticulum Calcium ATPase 2 in Murine Cardiomyocyte Maturation, Guo Y, Dong E, 2022 Sarcomeres regulate murine cardiomyocyte maturation through MRTF-SRF signaling, Guo Y, Pu WT, 2021 Cardiomyocyte Maturation: New Phase in Development, Guo Y, Pu WT, 2020 Hierarchical and stage-specific regulation of cardiomyocyte maturation by serum response factor, Guo Y, Pu WT, 2018 Genetic Mosaics for Greater Precision in Cardiovascular Research, Guo Y, Pu WT, 2018 Analysis of Cardiac Myocyte Maturation Using CASAAV, A Platform for Rapid Dissection of Cardiac Myocyte Gene Function In Vivo, Guo Y, Pu WT, 2017 Lamins position the nuclear pores and centrosomes by modulating dynein, Guo Y, Zheng Y, 2015 Concentration-dependent lamin assembly and its roles in the localization of other nuclear proteins, Guo Y, Zheng Y, 2014

Areas of Focus

Cardiomyocyte Development and Pathophysiology
Gene Editing and Gene Therapy
Stem Cells and Organoid Technology

Publications

Yap1 modulates cardiomyocyte hypertrophy via impaired mitochondrial biogenesis in response to chronic mechanical stress overload, Guo Y*, Hua Y*, Li Y*, 2022
Ryanodine receptor 2 (RYR2) dysfunction activates the unfolded protein response and perturbs cardiomyocyte maturation, Guo Y*, Pu WT*, 2022
Cas9/AAV9-Mediated Somatic Mutagenesis Uncovered the Cell-Autonomous Role of Sarcoplasmic/Endoplasmic Reticulum Calcium ATPase 2 in Murine Cardiomyocyte Maturation, Guo Y*, Dong E, 2022
Sarcomeres regulate murine cardiomyocyte maturation through MRTF-SRF signaling, Guo Y*, Pu WT*, 2021
Cardiomyocyte Maturation: New Phase in Development, Guo Y*, Pu WT*, 2020
Hierarchical and stage-specific regulation of cardiomyocyte maturation by serum response factor, Guo Y*, Pu WT*, 2018
Genetic Mosaics for Greater Precision in Cardiovascular Research, Guo Y*, Pu WT*, 2018
Analysis of Cardiac Myocyte Maturation Using CASAAV, A Platform for Rapid Dissection of Cardiac Myocyte Gene Function In Vivo, Guo Y*, Pu WT*, 2017
Lamins position the nuclear pores and centrosomes by modulating dynein, Guo Y*, Zheng Y*, 2015
Concentration-dependent lamin assembly and its roles in the localization of other nuclear proteins, Guo Y*, Zheng Y*, 2014

Cardiomyocyte Development Pathophysiology Gene Editing Therapy Stem Cells Organoid Technology

Qiang Shen - Fudan University

Dongming Su - Nanjing Medical University

Yun Chen - Nanjing Medical University

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