Upload Avatar (500 x 500)
Yu-Xuan Guo
Basic Medical Sciences
Peking University
Beijing
Language: English, Chinese
Cardiomyocyte
Development
Pathophysiology
Gene
Editing
Therapy
Stem
Cells
Organoid
Technology
Areas of Focus
- Cardiomyocyte Development and Pathophysiology
- Gene Editing and Gene Therapy
- Stem Cells and Organoid Technology
Work Experience
- 2015.9-2020.11 - Postdoctoral Fellow, Boston Children's Hospital, Harvard Medical School
- 2020.11-present - Researcher, Peking University Institute of Cardiovascular Research
Academic Background & Achievements
- 2006.9-2010.7 Bachelor: Peking University, School of Life Sciences
- 2010.8-2015.8 PhD: Johns Hopkins University, Department of Biology
Publications
- Yap1 modulates cardiomyocyte hypertrophy via impaired mitochondrial biogenesis in response to chronic mechanical stress overload, Guo Y*, Hua Y*, Li Y*, 2022
- Ryanodine receptor 2 (RYR2) dysfunction activates the unfolded protein response and perturbs cardiomyocyte maturation, Guo Y*, Pu WT*, 2022
- Cas9/AAV9-Mediated Somatic Mutagenesis Uncovered the Cell-Autonomous Role of Sarcoplasmic/Endoplasmic Reticulum Calcium ATPase 2 in Murine Cardiomyocyte Maturation, Guo Y*, Dong E, 2022
- Sarcomeres regulate murine cardiomyocyte maturation through MRTF-SRF signaling, Guo Y*, Pu WT*, 2021
- Cardiomyocyte Maturation: New Phase in Development, Guo Y*, Pu WT*, 2020
- Hierarchical and stage-specific regulation of cardiomyocyte maturation by serum response factor, Guo Y*, Pu WT*, 2018
- Genetic Mosaics for Greater Precision in Cardiovascular Research, Guo Y*, Pu WT*, 2018
- Analysis of Cardiac Myocyte Maturation Using CASAAV, A Platform for Rapid Dissection of Cardiac Myocyte Gene Function In Vivo, Guo Y*, Pu WT*, 2017
- Lamins position the nuclear pores and centrosomes by modulating dynein, Guo Y*, Zheng Y*, 2015
- Concentration-dependent lamin assembly and its roles in the localization of other nuclear proteins, Guo Y*, Zheng Y*, 2014
Awards
- 2018-2020: American Heart Association Postdoctoral Fellowship
- 2020: NIH Pathway to Independence Award (K99)
- 2021-2024: Beijing Science and Technology Rising Star
- 2022-2024: National Natural Science Foundation of China, Young Scientist Fund
- 2022-2025: National Natural Science Foundation of China, General Program
- 2022-2024: Beijing Science and Technology Rising Star Cross Cooperation Project
- 2022-2027: National Key R&D Program of China, Stem Cell and Organ Repair
- 2023-2025: National Natural Science Foundation of China, Excellent Young Scientist Fund
- 2023-2025: Beijing Natural Science Foundation, General Program
