Professor | Yun Chen | Asia Growth Partners

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Name	Yun Chen
Contact Information	chenyun@njmu.edu.cn
Language ability	Chinese, English
Province	Jiangsu

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Name

Yun Chen

Contact Information

chenyun@njmu.edu.cn

Language ability

Chinese, English

Province

Jiangsu

University/Lab Affiliation and Title	Nanjing Medical University
Faculty	Basic Medical Sciences
Academic Background & Achievements	1996-09 to 2001-07 Bachelor's in Clinical Medicine: Nanjing Medical University 2001-09 to 2007-07 Master's and Doctorate in Immunology: Nanjing Medical University Achievement: Published research in international journals such as Gut, Hepatology, and Science Advances
Work Experience	2017-06 to present - Nanjing Medical University, Director of the Department of Immunology 2007-09 to present - Nanjing Medical University, Lecturer/Associate Professor/Professor/Distinguished Professor 2012-09 to 2013-09 - UTHSCSA, Visiting Scholar 2008-06 to 2010-10 - Nanjing Medical University First Affiliated Hospital, Postdoctoral in Surgery
Awards	2021: Jiangsu Province Science and Technology Progress Award, Second Prize 2021: Jiangsu Province Natural Science Award, Second Prize 2018: Jiangsu Province 'Qinglan Project' Academic Leader 2017: Ministry of Education Higher Education Natural Science Award, First Prize 2016: Jiangsu Province Department of Education Higher Education Natural Science Award, Second Prize

University/Lab Affiliation and Title

Nanjing Medical University

Faculty

Basic Medical Sciences

Academic Background & Achievements

1996-09 to 2001-07 Bachelor's in Clinical Medicine: Nanjing Medical University
2001-09 to 2007-07 Master's and Doctorate in Immunology: Nanjing Medical University
Achievement: Published research in international journals such as Gut, Hepatology, and Science Advances

Work Experience

2017-06 to present - Nanjing Medical University, Director of the Department of Immunology
2007-09 to present - Nanjing Medical University, Lecturer/Associate Professor/Professor/Distinguished Professor
2012-09 to 2013-09 - UTHSCSA, Visiting Scholar
2008-06 to 2010-10 - Nanjing Medical University First Affiliated Hospital, Postdoctoral in Surgery

Awards

2021: Jiangsu Province Science and Technology Progress Award, Second Prize
2021: Jiangsu Province Natural Science Award, Second Prize
2018: Jiangsu Province 'Qinglan Project' Academic Leader
2017: Ministry of Education Higher Education Natural Science Award, First Prize
2016: Jiangsu Province Department of Education Higher Education Natural Science Award, Second Prize

Areas of Focus	Tumor Immunology Immune Microenvironment Cancer Immunotherapy
Publications	PD-L1 blockade liberates intrinsic antitumorigenic properties of glycolytic macrophages in hepatocellular carcinoma., Ligong Lu, Zhiling Zhou, Xuyan Wang, Boyuan Liu, Jinying Lu, Shuai Liu, Guangbo Zhang, Meixiao Zhan, Yun Chen, 2022 Single-cell profiling of human CD127+ innate lymphoid cells reveals diverse immune phenotypes in hepatocellular carcinoma., Yuanlin He, Jiajing Luo, Guannan Zhang, Yu Jin, Nanxi Wang, Jinying Lu, Changxian Li, Xiaohuan Guo, Na Qin, Juncheng Dai, Yun Chen, 2022 Gut microbiota-derived short-chain fatty acids regulates group 3 innate lymphoid cells in hepatocellular carcinoma., Chupeng Hu, Bingqing Xu, Xiaodong Wang, Wenhua Wan, Jinying Lu, Deyuan Kong, Yu Jin, Wenhua You, Hua Sun, Xiaoxin Mu, Dongju Feng, Yun Chen, 2022 c-Myc driven glycolysis polarizes functional regulatory B cells that trigger pathogenic inflammatory responses., Xuyan Wang, Yuan Wei, Yuan Liao, Wenhua Wan, Mahepali Mahabati, Zhengyu Liu, Jingrui Qu, Xiaodan Chen, Dongping Chen, Bo Hu, Xiaodong Wang, Dongming Kuang, Xuehao Wang, Yun Chen, 2022 Hepatic stellate cell activation and senescence induced by intrahepatic microbiota disturbances drive progression of liver cirrhosis towards Hepatocellular Carcinoma., Boyuan Liu, Zewei Zhou, Yu Jin, Jinying Lu, Dongju Feng, Rui Peng, Hua Sun, Xiaoxin Mu, Changxian Li, Yun Chen, 2022 Histone methyltransferase Nsd2 ensures maternal-fetal immune tolerance by promoting regulatory T cell recruitment., Le Zhang, Xuehui Long, Yuye Yin, Jun Wang, Huamin Zhu, Jingjing Chen, Yuliang Wang, Yun Chen, Xiaoming Wang, 2022 Tumor-associated macrophages promote PD-L1 expression in tumor cells by regulating PKM2 nuclear translocation in pancreatic ductal adenocarcinoma., Qing Xia, Jing Jia, Chupeng Hu, Jinying Lu, Jiajin Li, Haiyan Xu, Jianchen Fang, Dongju Feng, Liwei Wang, Yun Chen, 2022 B cells polarize pathogenic inflammatory T helper subsets through ICOSL-dependent glycolysis., Qiuhui Zeng, Yuan Wei, Xiangming Lao, Dongping Chen, Chunxiang Huang, Qianyi Lin, Min He, Yuan Liao, Limin Zheng, Bo Li, Guangbo Zhang, Yun Chen, Dongming Kuang, 2020 Prognostic value of novel immune-related genomic biomarkers identified in head and neck squamous cell carcinoma., Yao Yao, Zhongyi Yan, Senlin Lian, Liangnian Wei, Chao Zhou, Dongju Feng, Yuan Zhang, Jianrong Yang, Ming Li, Yun Chen, 2020 Listeria-based hepatocellular carcinoma vaccine facilitates anti-PD-1 therapy by regulating macrophage polarization., Guolong Xu, Dongju Feng, Yao Yao, Peipei Li, Hua Sun, Hong Yang, Changxian Li, Runqiu Jiang, Beicheng Sun, Yun Chen, 2020 Smoothened Promotes Glioblastoma Radiation Resistance Via Activating USP3-Mediated Claspin Deubiquitination., Yiming Tu, Zhenyao Chen, Pengzhan Zhao, Guangchi Sun, Zhongyuan Bao, Honglu Chao, Liang Fan, Chong Li, Yongping You, Yan Qu, Yun Chen, Jing Ji, 2020 IL-6 promotes PD-L1 expression in monocytes and macrophages by decreasing protein tyrosine phosphatase receptor type O expression in human hepatocellular carcinoma., Wenjie Zhang, Yang Liu, Zhongyi Yan, Hui Yang, Wei Sun, Yongliang Yao, Yun Chen, Runqiu Jiang, 2020 The long noncoding RNA lnc-EGFR stimulates T-regulatory cells differentiation thus promoting hepatocellular carcinoma immune evasion., Runqiu Jiang, Junwei Tang, Yun Chen, Lei Deng, Jie Ji, Yu Xie, Ke Wang, Wei Jia, Wenming Chu, Beicheng Sun, 2017

Areas of Focus

Tumor Immunology
Immune Microenvironment
Cancer Immunotherapy

Publications

PD-L1 blockade liberates intrinsic antitumorigenic properties of glycolytic macrophages in hepatocellular carcinoma., Ligong Lu, Zhiling Zhou, Xuyan Wang, Boyuan Liu, Jinying Lu, Shuai Liu, Guangbo Zhang, Meixiao Zhan, Yun Chen, 2022
Single-cell profiling of human CD127+ innate lymphoid cells reveals diverse immune phenotypes in hepatocellular carcinoma., Yuanlin He, Jiajing Luo, Guannan Zhang, Yu Jin, Nanxi Wang, Jinying Lu, Changxian Li, Xiaohuan Guo, Na Qin, Juncheng Dai, Yun Chen, 2022
Gut microbiota-derived short-chain fatty acids regulates group 3 innate lymphoid cells in hepatocellular carcinoma., Chupeng Hu, Bingqing Xu, Xiaodong Wang, Wenhua Wan, Jinying Lu, Deyuan Kong, Yu Jin, Wenhua You, Hua Sun, Xiaoxin Mu, Dongju Feng, Yun Chen, 2022
c-Myc driven glycolysis polarizes functional regulatory B cells that trigger pathogenic inflammatory responses., Xuyan Wang, Yuan Wei, Yuan Liao, Wenhua Wan, Mahepali Mahabati, Zhengyu Liu, Jingrui Qu, Xiaodan Chen, Dongping Chen, Bo Hu, Xiaodong Wang, Dongming Kuang, Xuehao Wang, Yun Chen, 2022
Hepatic stellate cell activation and senescence induced by intrahepatic microbiota disturbances drive progression of liver cirrhosis towards Hepatocellular Carcinoma., Boyuan Liu, Zewei Zhou, Yu Jin, Jinying Lu, Dongju Feng, Rui Peng, Hua Sun, Xiaoxin Mu, Changxian Li, Yun Chen, 2022
Histone methyltransferase Nsd2 ensures maternal-fetal immune tolerance by promoting regulatory T cell recruitment., Le Zhang, Xuehui Long, Yuye Yin, Jun Wang, Huamin Zhu, Jingjing Chen, Yuliang Wang, Yun Chen, Xiaoming Wang, 2022
Tumor-associated macrophages promote PD-L1 expression in tumor cells by regulating PKM2 nuclear translocation in pancreatic ductal adenocarcinoma., Qing Xia, Jing Jia, Chupeng Hu, Jinying Lu, Jiajin Li, Haiyan Xu, Jianchen Fang, Dongju Feng, Liwei Wang, Yun Chen, 2022
B cells polarize pathogenic inflammatory T helper subsets through ICOSL-dependent glycolysis., Qiuhui Zeng, Yuan Wei, Xiangming Lao, Dongping Chen, Chunxiang Huang, Qianyi Lin, Min He, Yuan Liao, Limin Zheng, Bo Li, Guangbo Zhang, Yun Chen, Dongming Kuang, 2020
Prognostic value of novel immune-related genomic biomarkers identified in head and neck squamous cell carcinoma., Yao Yao, Zhongyi Yan, Senlin Lian, Liangnian Wei, Chao Zhou, Dongju Feng, Yuan Zhang, Jianrong Yang, Ming Li, Yun Chen, 2020
Listeria-based hepatocellular carcinoma vaccine facilitates anti-PD-1 therapy by regulating macrophage polarization., Guolong Xu, Dongju Feng, Yao Yao, Peipei Li, Hua Sun, Hong Yang, Changxian Li, Runqiu Jiang, Beicheng Sun, Yun Chen, 2020
Smoothened Promotes Glioblastoma Radiation Resistance Via Activating USP3-Mediated Claspin Deubiquitination., Yiming Tu, Zhenyao Chen, Pengzhan Zhao, Guangchi Sun, Zhongyuan Bao, Honglu Chao, Liang Fan, Chong Li, Yongping You, Yan Qu, Yun Chen, Jing Ji, 2020
IL-6 promotes PD-L1 expression in monocytes and macrophages by decreasing protein tyrosine phosphatase receptor type O expression in human hepatocellular carcinoma., Wenjie Zhang, Yang Liu, Zhongyi Yan, Hui Yang, Wei Sun, Yongliang Yao, Yun Chen, Runqiu Jiang, 2020
The long noncoding RNA lnc-EGFR stimulates T-regulatory cells differentiation thus promoting hepatocellular carcinoma immune evasion., Runqiu Jiang, Junwei Tang, Yun Chen, Lei Deng, Jie Ji, Yu Xie, Ke Wang, Wei Jia, Wenming Chu, Beicheng Sun, 2017

Tumor Immunology Microenvironment Cancer Therapy Immune Cells Network Mechanism Vaccine

Ying Zhao - Peking University

Wenhua Yu - Peking University

Zhan Jun - Peking University

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