Areas of Focus
- 肿瘤免疫
- 免疫微环境
- 癌症免疫治疗
Work Experience
- 2017-06至今 - 南京医科大学,免疫学系主任
- 2007-09至今 - 南京医科大学,讲师/副教授/教授/特聘教授
- 2012-09至2013-09 - 美国UTHSCSA,访问学者
- 2008-06至2010-10 - 南京医科大学第一附属医院,外科学博士后
Academic Background & Achievements
- 1996-09至2001-07 临床医学学士:南京医科大学
- 2001-09至2007-07 免疫学硕士和博士:南京医科大学
- 成就:在国际期刊如Gut、Hepatology和Science Advances上发表研究
Publications
- PD-L1阻断释放肝细胞癌中糖酵解巨噬细胞的内在抗肿瘤特性。, Ligong Lu, Zhiling Zhou, Xuyan Wang, Boyuan Liu, Jinying Lu, Shuai Liu, Guangbo Zhang, Meixiao Zhan, Yun Chen, 2022
- 人类CD127+先天淋巴细胞的单细胞分析揭示了肝细胞癌中的多样性免疫表型。, Yuanlin He, Jiajing Luo, Guannan Zhang, Yu Jin, Nanxi Wang, Jinying Lu, Changxian Li, Xiaohuan Guo, Na Qin, Juncheng Dai, Yun Chen, 2022
- 肠道微生物群衍生的短链脂肪酸调节肝细胞癌中的3型先天淋巴细胞。, Chupeng Hu, Bingqing Xu, Xiaodong Wang, Wenhua Wan, Jinying Lu, Deyuan Kong, Yu Jin, Wenhua You, Hua Sun, Xiaoxin Mu, Dongju Feng, Yun Chen, 2022
- c-Myc驱动的糖酵解极化功能性调节性B细胞,触发致病性炎症反应。, Xuyan Wang, Yuan Wei, Yuan Liao, Wenhua Wan, Mahepali Mahabati, Zhengyu Liu, Jingrui Qu, Xiaodan Chen, Dongping Chen, Bo Hu, Xiaodong Wang, Dongming Kuang, Xuehao Wang, Yun Chen, 2022
- 肝内微生物群紊乱诱导的肝星状细胞激活和衰老推动肝硬化向肝细胞癌的进展。, Boyuan Liu, Zewei Zhou, Yu Jin, Jinying Lu, Dongju Feng, Rui Peng, Hua Sun, Xiaoxin Mu, Changxian Li, Yun Chen, 2022
- 组蛋白甲基转移酶Nsd2通过促进调节性T细胞募集确保母胎免疫耐受。, Le Zhang, Xuehui Long, Yuye Yin, Jun Wang, Huamin Zhu, Jingjing Chen, Yuliang Wang, Yun Chen, Xiaoming Wang, 2022
- 肿瘤相关巨噬细胞通过调节胰腺导管腺癌中PKM2的核转位促进肿瘤细胞的PD-L1表达。, Qing Xia, Jing Jia, Chupeng Hu, Jinying Lu, Jiajin Li, Haiyan Xu, Jianchen Fang, Dongju Feng, Liwei Wang, Yun Chen, 2022
- B细胞通过ICOSL依赖的糖酵解极化致病性炎症性T辅助亚群。, Qiuhui Zeng, Yuan Wei, Xiangming Lao, Dongping Chen, Chunxiang Huang, Qianyi Lin, Min He, Yuan Liao, Limin Zheng, Bo Li, Guangbo Zhang, Yun Chen, Dongming Kuang, 2020
- 在头颈部鳞状细胞癌中识别的新型免疫相关基因组生物标志物的预后价值。, Yao Yao, Zhongyi Yan, Senlin Lian, Liangnian Wei, Chao Zhou, Dongju Feng, Yuan Zhang, Jianrong Yang, Ming Li, Yun Chen, 2020
- 基于李斯特菌的肝细胞癌疫苗通过调节巨噬细胞极化促进抗PD-1治疗。, Guolong Xu, Dongju Feng, Yao Yao, Peipei Li, Hua Sun, Hong Yang, Changxian Li, Runqiu Jiang, Beicheng Sun, Yun Chen, 2020
- Smoothened通过激活USP3介导的Claspin去泛素化促进胶质母细胞瘤的放射抗性。, Yiming Tu, Zhenyao Chen, Pengzhan Zhao, Guangchi Sun, Zhongyuan Bao, Honglu Chao, Liang Fan, Chong Li, Yongping You, Yan Qu, Yun Chen, Jing Ji, 2020
- IL-6通过降低人肝细胞癌中蛋白酪氨酸磷酸酶受体型O的表达促进单核细胞和巨噬细胞中的PD-L1表达。, Wenjie Zhang, Yang Liu, Zhongyi Yan, Hui Yang, Wei Sun, Yongliang Yao, Yun Chen, Runqiu Jiang, 2020
- 长链非编码RNA lnc-EGFR刺激T调节细胞分化,从而促进肝细胞癌的免疫逃逸。, Runqiu Jiang, Junwei Tang, Yun Chen, Lei Deng, Jie Ji, Yu Xie, Ke Wang, Wei Jia, Wenming Chu, Beicheng Sun, 2017
Awards
- 2021:江苏省科技进步奖二等奖
- 2021:江苏省自然科学奖二等奖
- 2018:江苏省“青蓝工程”学术带头人
- 2017:教育部高等学校自然科学奖一等奖
- 2016:江苏省教育厅高等学校自然科学奖二等奖