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Pengyan Xia
Basic Medical Sciences
Peking University
Beijing
Language: Chinese, English
Pattern Recognition Receptors
Pathogenic Molecules
Nlrp3 Inflammasome
Activation Mechanisms
Enteritis
Dermatitis
Immune Response
Molecular Mechanisms
Inflammation
Pathogen Infection
Areas of Focus
- Discovery of new pattern recognition receptors, Identification of new characteristic pathogenic molecules
- Exploration of the activation mechanisms of the NLRP3 inflammasome and its role in enteritis and dermatitis
Work Experience
- 2018 - Present - Peking University, Researcher and Doctoral Supervisor
Academic Background & Achievements
- Joined Peking University School of Basic Medical Sciences, Department of Immunology in December 2018
Publications
- Adipose triglyceride lipase suppresses non-canonical inflammasome by hydrolyzing LPS, Li W, Liu Q, Qian Y, Wang C, Kong C, Sun L, Sun L, Liu H, Zhang Y, Jiang D, Jiang C, Wang S, Xia P*, 2024
- The orphan receptor Nur77 binds cytoplasmic LPS to activate the non-canonical NLRP3 inflammasome, Zhu F, Ma J, Li W, Liu Q, Qin X, Qian Y, Wang C, Zhang Y, Li Y, Jiang D, Wang S*, Xia P*, 2023
- Tissue-resident Lachnospiraceae family bacteria protect against colorectal carcinogenesis by promoting tumor immune surveillance, Zhang X, Yu D, Wu D, Gao X, Shao F, Zhao M, Wang J, Ma J, Wang W, Qin X, Chen Y*, Xia P*, Wang S*, 2023
- The neuropeptide CGRP enters the macrophage cytosol to suppress the NLRP3 inflammasome during pulmonary infection, Zhu F, Yu D, Qin X, Qian Y, Ma J, Li W, Liu Q, Wang C, Zhang Y, Li Y, Jiang D, Wang S*, Xia P*, 2023
- AA467197 controls the hyperactivation of the NLRP3 inflammasome during infection, Liu Q, Li W, Qian Y, Wang C, Xia P*, 2023
- Maturation and specialization of group 2 innate lymphoid cells through the lung-gut axis, Zhao M, Shao F, Yu D, Zhang J, Liu Z, Ma J, Xia P*, Wang S*, 2022
- SARS-CoV-2 nucleocapsid suppresses host pyroptosis by blocking Gasdermin D cleavage, Ma J, Zhu F, Zhao M, Shao F, Yu D, Ma J, Zhang X, Li W, Qian Y, Zhang Y, Jiang D, Wang S*, Xia P*, 2021
Awards
- 2023: Beijing Outstanding Young Scientist Fund
- 2023: Fifth 'Peking University Young Scientist Award'
- 2023: Peking University Excellent Doctoral Dissertation Instructor
- 2023: Peking University Medical Department Teaching Excellence Award
- 2022: Peking University Medical Department Teaching Achievement Third Prize
- 2021: Peking University School of Basic Medical Sciences Excellent Teacher Award
- 2021: Beijing Natural Science Award Second Prize
- 2020: Fok Ying Tung Young Teacher Fund
- 2020: Peking University Green Leaf Biopharma Outstanding Young Scholar Award
- 2020: Peking University Boya Young Scholar
- 2019: Peking University School of Basic Medical Sciences Young Teacher Award Fund
- 2019: Peking University School of Basic Medical Sciences Sanquan Education Award
- 2018: Beijing Science and Technology Award First Prize
