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Jinfang Zhang
Immunology and Metabolion
Wuhan University
Hubei
Language: Chinese, English
Immunology
Cancer
Therapy
Antibodies
Car T Cells
Target Discovery
Molecular Biology
Biochemistry
Cell Therapy
Clinical Research
Areas of Focus
- Tumor Immunology
- Novel Immunotherapy Targets Discovery
- Therapeutic Antibodies
- CAR T Product Development
Work Experience
- 2012-2013 Assistant Researcher, Institute of Microbiology, Chinese Academy of Sciences
- 2013-2015 Postdoctoral Fellow, Beth Deaconess Medical Center, Harvard Medical School
- 2015-2018 Instructor, Harvard Medical School/Harvard School of Dental Medicine
- 2019-present Professor, Medical Research Institute, Wuhan University
Academic Background & Achievements
- 2001-2005 Bachelor of Life Sciences, Nanyang Normal University
- 2005-2008 Master of Biochemistry and Molecular Biology, Capital Normal University
- 2008-2012 PhD in Biochemistry and Molecular Biology, Peking University
Publications
- USP8-governed GPX4 homeostasis orchestrates ferroptosis and cancer immunotherapy, Zhang JF et al., 2024
- UFL1 ablation in T cells suppresses PD-1 UFMylation to enhance anti-tumor immunity, Zhang JF et al., 2024
- ERK and USP5 govern PD-1 homeostasis via deubiquitination to modulate tumor immunotherapy, Zhang JF et al., 2023
- USP8 inhibition reshapes an inflamed tumor microenvironment that potentiates the immunotherapy, Zhang JF et al., 2022
- Extracellular and nuclear PD-L1 in modulating cancer immunotherapy, Zhang JF et al., 2021
- PARP inhibitor plus radiotherapy reshapes an inflamed tumor microenvironment that sensitizes small cell lung cancer to the anti-PD-1 immunotherapy, Zhang JF et al., 2023
- Cyclin D-CDK4 kinase destabilizes PD-L1 via cullin 3-SPOP to control cancer immune surveillance, Zhang JF et al., 2018
- PTEN Methylation by NSD2 Controls Cellular Sensitivity to DNA Damage, Zhang JF et al., 2019
- SPOP Promotes Nanog Destruction to Suppress Stem Cell Traits and Prostate Cancer Progression, Zhang JF et al., 2019
- Phosphorylation of EZH2 by AMPK Suppresses PRC2 Methyltransferase Activity and Oncogenic Function, Zhang JF et al., 2018
- Biochemical Aspects of PD-L1 Regulation in Cancer Immunotherapy, Zhang JF et al., 2018
Awards
- 2019: National Overseas High-Level Talents Introduction Program for Young Professionals
