Areas of Focus
- Antiviral natural immunity
- Inflammation
- Inflammation to cancer transformation
- Tumor immunotherapy
Work Experience
- 1990-1992 Research Assistant, University of Michigan Medical Center
- 1997-1998 Senior Scientist, Magainin Pharmaceuticals
- 1998-2003 Assistant Professor, Jewish Medical Research Center and University of Colorado Health Sciences Center, Immunology Department
- 2003-2005 Associate Professor, Jewish Medical Research Center and University of Colorado Health Sciences Center, Immunology Department
- 2000-2004 Changjiang Distinguished Professor, Peking University College of Life Sciences
- 2005-2013 Professor and Dean, Wuhan University College of Life Sciences
- 2013-2022 Vice President, Wuhan University
- 2014- Dean, Wuhan University Medical Research Institute
- 2019- Chief Scientist, Ministry of Education Center for Immunology and Metabolism
- 2019- Director, Chinese Academy of Medical Sciences Innovation Unit for Natural Immunity and Inflammatory Diseases
- 2022- Dean, Wuhan Institute of Biotechnology
Academic Background & Achievements
- 1983-1987 Bachelor in Zoology, Lanzhou University
- 1987-1990 Master in Cell Biology, Chinese Academy of Medical Sciences
- 1992-1995 PhD in Cell and Developmental Biology, Emory University
Publications
- TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor-1 signal transduction pathways, Hsu H, Shu HB, Pan MG, Goeddel DV, 1996
- The tumor necrosis factor receptor 2 signal transducers TRAF2 and c-IAP1 are components of the tumor necrosis factor receptor 1 signaling complex, Shu HB, Takeuchi M, Goeddel DV, 1996
- Casper is a FADD and Caspase-related Inducer of Apoptosis, Shu HB, Halpins DR, Goeddel DV, 1997
- FADD: essential for embryonic development and signaling from some, but not all, inducers of apoptosis, Yeh WC, Pompa JL, McCurrach ME, Shu HB, Elia AJ, Shahinian A, Ng M, Wajegam A, Mithchell K, El-Deiry WS, Lowe SW, Goeddel DV, Mak TW, 1998
- TALL-1 is a novel member of the TNF family that is downregulated by mitogens, Shu HB, Hu WH, Johnson H, 1999
- BCMA is a receptor for the TNF family member TALL-1, Shu HB, Johnson H, 2000
- Crystal structure of sTALL-1 reveals a virus-like assembly of TNF family ligands, Liu Y, Xu L, Opalka N, Kappler J, Shu HB, Zhang G, 2002
- Ligand-receptor binding revealed by the TNF family member TALL-1, Liu Y, Hong X, Kappler J, Jiang L, Zhang R, Xu L, Pan CH, Martin WE, Murphy RC, Shu HB, Dai S, Zhang G, 2003
- VISA is an adapter protein required for virus-triggered signaling, Xu LG, Wang YY, Han KJ, Li LY, Zhai Z, Shu HB, 2005
- SIKE is an IKK-relative kinases-associated suppressor of TLR3- and virus-triggered IRF-3 activation pathways, Huang J, Liu T, Chen D, Zhai Z, Shu HB, 2005
Awards
- Academician of the Chinese Academy of Sciences (2011)
- Academician of the Academy of Sciences for the Developing World (2012)
- Nature Outstanding Mentor Award (2015)
- National Natural Science Second Prize (First Completer, 2010, 2015)
- Ministry of Education Natural Science Award First Prize (First Completer, 2006, 2014)
- Hubei Province Outstanding Contribution to Science and Technology Award (2022)
- Standing Committee Member of the 13th National Committee of the Chinese People's Political Consultative Conference (2018-2023)
- Standing Committee Member of the 14th National Committee of the Chinese People's Political Consultative Conference (2023-)
- Editor-in-Chief of Cell Insight (2021-)