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Qiang Chen
Immunology and Metabolion
Wuhan University
Hubei
Language: Chinese, English
Dna Damage
Genomic Instability
Cancer
Cell Cycle
Mutation
Tumor
Dna Repair
Molecular Mechanisms
Disease Prevention
Cell Survival
Areas of Focus
- DNA damage, genomic instability, and cancer development
Work Experience
- 2008-2010 Postdoctoral Researcher, Peking University, School of Life Sciences
- 2010-2015 Postdoctoral Researcher, University of Michigan Medical School, USA
- 2015-2016 Postdoctoral Researcher, City of Hope Beckman Research Institute, USA
- 2016-Present Professor, Wuhan University Medical Research Institute
Academic Background & Achievements
- 1998-2002 Bachelor: Shandong University, School of Life Sciences
- 2002-2008 Ph.D.: Peking University, School of Life Sciences
Publications
- LUC7L3 is a downstream factor of SRSF1 and prevents genomic instability, Zhang X, Guo J, Shi X, Zhou X, Chen Q*
- SCML2 contributes to tumor cell resistance to DNA damage through regulating p53 and CHK1 stability, Peng Q, Shi X, Li D, Guo J, Zhang X, Zhang X, Chen Q*, 2023
- Role of PARP-1 in Human Cytomegalovirus Infection and Functional Partners Encoded by This Virus, Zhang W, Guo J, Chen Q*, 2022
- O-GlcNAc transferase promotes the nuclear localization of the focal adhesion-associated protein Zyxin to regulate UV-induced cell death, Zhao Y, Yue S, Zhou X, Guo J, Ma S, Chen Q*, 2022
- Centrosome, microtubule and DNA damage response, Li, D., Liu, X. & Chen, Q*, 2022
- A Novel Mouse Model Harboring Hepatitis B Virus Covalently Closed Circular DNA, Xu Z, Zhao L, Zhong Y, Zhu C, Zhao K, Teng Y, Cheng X, Chen Q, Xia Y, 2022
- DNA damage promotes microtubule dynamics through a DNA-PK-AKT axis for enhanced repair, Ma S, Rong Z, Liu C, Qin X, Zhang X, Chen Q*, 2021
- Phosphorylation of cGAS by CDK1 impairs self-DNA sensing in mitosis, Zhong L, Hu MM, Bian LJ, Liu Y, Chen Q, Shu HB, 2020
- A methylation-phosphorylation switch determines Plk1 kinase activity and function in DNA damage repair, Li W, Wang HY, Zhao X, Duan H, Cheng B, Liu Y, Zhao M, Shu W, Mei Y, Wen Z, Tang M, Guo L, Li G, Chen Q, Liu X, Du HN, 2019
- OGT restrains the expansion of DNA damage signaling, Chen, Q. and Yu, X., 2016
- Usp16 regulates kinetochore localization of Plk1 to promote proper chromosome alignment in mitosis, Zhuo, X., Guo, X., Zhang, X., Jing, G., Wang, Y., Chen, Q., Jiang, Q., Liu, J. and Zhang, C., 2015
- The zinc finger proteins ZNF644 and WIZ regulate the G9a/GLP complex for gene repression, Bian, C., Chen, Q., Yu, X., 2015
- PCM1 recruits Plk1 to the pericentriolar matrix to promote primary cilia disassembly before mitotic entry, Wang, G., Chen, Q., Zhang, X., Zhang, B., Zhuo, X., Liu, J., Jiang, Q., Zhang, C., 2013
- TET2 promotes histone O-GlcNAcylation during gene transcription, Chen, Q., Chen, Y., Bian, C., Fujiki, R., Yu, X., 2013
- Sequential phosphorylation of Nedd1 by Cdk1 and Plk1 is required for targeting of the gammaTuRC to the centrosome, Zhang, X., Chen, Q., Feng, J., Hou, J., Yang, F., Liu, J., Jiang, Q., Zhang, C., 2009
- Cyclin B1 is localized to unattached kinetochores and contributes to efficient microtubule attachment and proper chromosome alignment during mitosis, Chen, Q., Zhang, X., Jiang, Q., Clarke, P.R., Zhang, C., 2008
