Professor | Han Han | Asia Growth Partners

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Name	Han Han
Contact Information	hanhan@whu.edu.cn
Language ability	Chinese, English
Province	Hubei

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Name

Han Han

Contact Information

hanhan@whu.edu.cn

Language ability

Chinese, English

Province

Hubei

University/Lab Affiliation and Title	Wuhan University
Faculty	Basic Medical Sciences
Academic Background & Achievements	2010 - 2015 PhD in Cell Biology, College of Life Sciences, Wuhan University 2006 - 2010 Bachelor in Biotechnology, College of Life Sciences, Ningxia University
Work Experience	2023 - Present Professor at Basic Medical College, Wuhan University Taikang Medical College; PI at Taikang Center for Life Sciences 2020 - 2023 Associate Research Specialist, Department of Developmental and Cell Biology, University of California, Irvine 2016 - 2020 Postdoctoral Researcher, Department of Developmental and Cell Biology, University of California, Irvine 2015 - 2016 Postdoctoral Researcher, Department of Experimental Radiation Oncology, University of Texas MD Anderson Cancer Center
Awards	National Talent Project (2022) Key Contact Expert of Hubei Province (2021) Dean's Award for Excellence in Research, University of California, Irvine (2018) Wuhan University Academic Innovation Award (2016)

University/Lab Affiliation and Title

Wuhan University

Faculty

Basic Medical Sciences

Academic Background & Achievements

2010 - 2015 PhD in Cell Biology, College of Life Sciences, Wuhan University
2006 - 2010 Bachelor in Biotechnology, College of Life Sciences, Ningxia University

Work Experience

2023 - Present Professor at Basic Medical College, Wuhan University Taikang Medical College; PI at Taikang Center for Life Sciences
2020 - 2023 Associate Research Specialist, Department of Developmental and Cell Biology, University of California, Irvine
2016 - 2020 Postdoctoral Researcher, Department of Developmental and Cell Biology, University of California, Irvine
2015 - 2016 Postdoctoral Researcher, Department of Experimental Radiation Oncology, University of Texas MD Anderson Cancer Center

Awards

National Talent Project (2022)
Key Contact Expert of Hubei Province (2021)
Dean's Award for Excellence in Research, University of California, Irvine (2018)
Wuhan University Academic Innovation Award (2016)

Areas of Focus	Cellular biology as a fundamental unit of life Maintenance of intracellular homeostasis Stress response signaling networks Dysregulation in diseases like cancer Genomics and proteomics methodologies Gene knockout cell and mouse models Clinical case integration Tumor suppressor pathways, specifically the Hippo signaling pathway Phospholipid metabolism in tumor suppression Heavy metal homeostasis via Hippo pathway activity
Publications	A tale of two Hippo pathway modules, Han H, Wang W, 2023 The Hippo pathway kinases LATS1 and LATS2 attenuate cellular responses to heavy metals through phosphorylating MTF1, Han H, Nakaoka HJ, Hofmann L, Zhou JJ, Yu C, et al., 2022 Systematic analysis of the Hippo pathway organization and oncogenic alteration in evolution, Chen Y, Han H, Seo G, Vargas RE, Yang B, et al., 2020 Elucidation of WW domain ligand binding specificities in the Hippo pathway reveals STXBP4 as YAP inhibitor, Vargas RE, Duong VT, Han H, Ta AP, Chen Y, et al., 2020 Regulation of the Hippo pathway by phosphatidic acid-mediated lipid-protein interaction, Han H, Qi R, Zhou JJ, Ta AP, Yang B, et al., 2018 Hippo signaling dysfunction induces cancer cell addiction to YAP, Han H, Yang B, Nakaoka HJ, Yang J, Zhao Y, et al., 2018 LncRNA wires up Hippo and hedgehog signaling to reprogram glucose metabolism, Zheng X, Han H, Liu G, Ma Y, Pan R, et al., 2017 Angiomotin-like 2 interacts with and negatively regulates AKT, Han H, Yang B, Wang W, 2017 Proteomic analysis of the human tankyrase protein interaction network reveals its role in pexophagy, Li X, Han H, Zhou MT*, Yang B, Ta AP, et al., 2017 microRNA-129-5p, a c-Myc negative target, affects hepatocellular carcinoma progression by blocking the Warburg effect, Han H, Li W, Shen H, Zhang J, Zhu Y, et al., 2016

Areas of Focus

Cellular biology as a fundamental unit of life
Maintenance of intracellular homeostasis
Stress response signaling networks
Dysregulation in diseases like cancer
Genomics and proteomics methodologies
Gene knockout cell and mouse models
Clinical case integration
Tumor suppressor pathways, specifically the Hippo signaling pathway
Phospholipid metabolism in tumor suppression
Heavy metal homeostasis via Hippo pathway activity

Publications

A tale of two Hippo pathway modules, Han H, Wang W, 2023
The Hippo pathway kinases LATS1 and LATS2 attenuate cellular responses to heavy metals through phosphorylating MTF1, Han H, Nakaoka HJ, Hofmann L, Zhou JJ, Yu C, et al., 2022
Systematic analysis of the Hippo pathway organization and oncogenic alteration in evolution, Chen Y*, Han H*, Seo G, Vargas RE, Yang B, et al., 2020
Elucidation of WW domain ligand binding specificities in the Hippo pathway reveals STXBP4 as YAP inhibitor, Vargas RE*, Duong VT*, Han H*, Ta AP, Chen Y, et al., 2020
Regulation of the Hippo pathway by phosphatidic acid-mediated lipid-protein interaction, Han H, Qi R, Zhou JJ, Ta AP, Yang B, et al., 2018
Hippo signaling dysfunction induces cancer cell addiction to YAP, Han H, Yang B, Nakaoka HJ, Yang J, Zhao Y, et al., 2018
LncRNA wires up Hippo and hedgehog signaling to reprogram glucose metabolism, Zheng X*, Han H*, Liu G*, Ma Y, Pan R, et al., 2017
Angiomotin-like 2 interacts with and negatively regulates AKT, Han H, Yang B, Wang W, 2017
Proteomic analysis of the human tankyrase protein interaction network reveals its role in pexophagy, Li X*, Han H*, Zhou MT*, Yang B, Ta AP, et al., 2017
microRNA-129-5p, a c-Myc negative target, affects hepatocellular carcinoma progression by blocking the Warburg effect, Han H, Li W, Shen H, Zhang J, Zhu Y, et al., 2016

Cell Biology Homeostasis Stress Response Signaling Networks Cancer Genomics Proteomics Gene Knockout Hippo Pathway Phospholipid Metabolism

Xiaowei Zhang - Peking University

Ying Zhao - Peking University

Chunhong Zheng - Peking University

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