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Han Han
Basic Medical Sciences
Wuhan University
Hubei
Language: Chinese, English
Cell Biology
Homeostasis
Stress Response
Signaling Networks
Cancer
Genomics
Proteomics
Gene Knockout
Hippo Pathway
Phospholipid Metabolism
Areas of Focus
- Cellular biology as a fundamental unit of life
- Maintenance of intracellular homeostasis
- Stress response signaling networks
- Dysregulation in diseases like cancer
- Genomics and proteomics methodologies
- Gene knockout cell and mouse models
- Clinical case integration
- Tumor suppressor pathways, specifically the Hippo signaling pathway
- Phospholipid metabolism in tumor suppression
- Heavy metal homeostasis via Hippo pathway activity
Work Experience
- 2023 - Present Professor at Basic Medical College, Wuhan University Taikang Medical College; PI at Taikang Center for Life Sciences
- 2020 - 2023 Associate Research Specialist, Department of Developmental and Cell Biology, University of California, Irvine
- 2016 - 2020 Postdoctoral Researcher, Department of Developmental and Cell Biology, University of California, Irvine
- 2015 - 2016 Postdoctoral Researcher, Department of Experimental Radiation Oncology, University of Texas MD Anderson Cancer Center
Academic Background & Achievements
- 2010 - 2015 PhD in Cell Biology, College of Life Sciences, Wuhan University
- 2006 - 2010 Bachelor in Biotechnology, College of Life Sciences, Ningxia University
Publications
- A tale of two Hippo pathway modules, Han H, Wang W, 2023
- The Hippo pathway kinases LATS1 and LATS2 attenuate cellular responses to heavy metals through phosphorylating MTF1, Han H, Nakaoka HJ, Hofmann L, Zhou JJ, Yu C, et al., 2022
- Systematic analysis of the Hippo pathway organization and oncogenic alteration in evolution, Chen Y*, Han H*, Seo G, Vargas RE, Yang B, et al., 2020
- Elucidation of WW domain ligand binding specificities in the Hippo pathway reveals STXBP4 as YAP inhibitor, Vargas RE*, Duong VT*, Han H*, Ta AP, Chen Y, et al., 2020
- Regulation of the Hippo pathway by phosphatidic acid-mediated lipid-protein interaction, Han H, Qi R, Zhou JJ, Ta AP, Yang B, et al., 2018
- Hippo signaling dysfunction induces cancer cell addiction to YAP, Han H, Yang B, Nakaoka HJ, Yang J, Zhao Y, et al., 2018
- LncRNA wires up Hippo and hedgehog signaling to reprogram glucose metabolism, Zheng X*, Han H*, Liu G*, Ma Y, Pan R, et al., 2017
- Angiomotin-like 2 interacts with and negatively regulates AKT, Han H, Yang B, Wang W, 2017
- Proteomic analysis of the human tankyrase protein interaction network reveals its role in pexophagy, Li X*, Han H*, Zhou MT*, Yang B, Ta AP, et al., 2017
- microRNA-129-5p, a c-Myc negative target, affects hepatocellular carcinoma progression by blocking the Warburg effect, Han H, Li W, Shen H, Zhang J, Zhu Y, et al., 2016
Awards
- National Talent Project (2022)
- Key Contact Expert of Hubei Province (2021)
- Dean's Award for Excellence in Research, University of California, Irvine (2018)
- Wuhan University Academic Innovation Award (2016)
