Professor | Lei Han | Asia Growth Partners

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Name	Lei Han
Contact Information	hanleibio2005@gmail.com
Language ability	Chinese, English
Province	Hubei

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Name

Lei Han

Contact Information

hanleibio2005@gmail.com

Language ability

Chinese, English

Province

Hubei

University/Lab Affiliation and Title	Wuhan University
Faculty	Basic Medical Sciences
Academic Background & Achievements	2005-2009 Bachelor in Bioengineering, Beijing University of Chemical Technology 2009-2012 Master in Biochemistry and Molecular Biology, Chinese Academy of Agricultural Sciences 2012-2017 PhD in Biochemistry and Molecular Biology, Institute of Biophysics, Chinese Academy of Sciences
Work Experience	2017-2023 Postdoctoral Researcher, Department of Molecular and Cellular Physiology, Stanford University 2023-present Professor, Taikang School of Medicine (Basic Medical College), Wuhan University, PI at Taikang Life Medical Center
Awards	Dean's Postdoctoral Fellowship, School of Medicine, Stanford University (2019) National Talent Program Awardee

University/Lab Affiliation and Title

Wuhan University

Faculty

Basic Medical Sciences

Academic Background & Achievements

2005-2009 Bachelor in Bioengineering, Beijing University of Chemical Technology
2009-2012 Master in Biochemistry and Molecular Biology, Chinese Academy of Agricultural Sciences
2012-2017 PhD in Biochemistry and Molecular Biology, Institute of Biophysics, Chinese Academy of Sciences

Work Experience

2017-2023 Postdoctoral Researcher, Department of Molecular and Cellular Physiology, Stanford University
2023-present Professor, Taikang School of Medicine (Basic Medical College), Wuhan University, PI at Taikang Life Medical Center

Awards

Dean's Postdoctoral Fellowship, School of Medicine, Stanford University (2019)
National Talent Program Awardee

Areas of Focus	Mechanisms of transmembrane transport proteins and drug development research Important metabolic transport proteins related to major diseases and their research potential as drug targets
Publications	Structure and mechanism of the alkane-oxidizing enzyme AlkB, Xue Guo, Jianxiu Zhang, Lei Han, Juliet Lee, Shoshana C Williams, Allison Forsberg, Yan Xu, Rachel Narehood Austin, Liang Feng, 2023 Structure and mechanism of the SGLT family of glucose transporters, Lei Han, Qianhui Qu, Deniz Aydin, Ouliana Panova, Michael J Robertson, Yan Xu, Ron O Dror, Georgios Skiniotis, Liang Feng, 2022 Molecular mechanism of substrate recognition and transport by the AtSWEET13 sugar transporter, Lei Han, Yongping Zhu, Min Liu, Ye Zhou, Guangyuan Lu, Lan Lan, Xianping Wang, Yongfang Zhao, Xuejun C Zhang, 2017 Energy coupling mechanisms of AcrB-like RND transporters, Xuejun C Zhang, Min Liu, Lei Han, 2017 The asparagine-rich protein NRP interacts with the Verticillium effector PevD1 and regulates the subcellular localization of cryptochrome 2, Ruimin Zhou, Tong Zhu, Lei Han, Mengjie Liu, Mengyuan Xu, Yanli Liu, Dandan Han, Dewen Qiu, Qingqiu Gong, Xinqi Liu, 2017 Uniporter substrate binding and transport: reformulating mechanistic questions, Xuejun C Zhang, Lei Han, 2016 How does a beta-barrel integral membrane protein insert into the membrane?, Xuejun C Zhang, Lei Han, 2016 How does the chemical potential of the substrate drive a uniporter?, Xuejun C Zhang, Lei Han, 2016 Thermodynamics of ABC transporters, Xuejun C Zhang, Lei Han, Yan Zhao, 2016 Purification, crystallization and preliminary X-ray diffraction analysis of the effector protein PevD1 from Verticillium dahliae, Lei Han, Zheng Liu, Xinqi Liu, Dewen Qiu, 2012 Purification and characterization of a novel antimicrobial peptide from Brevibacillus laterosporus strain A60, Jing Zhao, Lihua Guo, Hongmei Zeng, Xiufen Yang, Jingjing Yuan, Huaixing Shi, Yehui Xiong, Mingjia Chen, Lei Han, Dewen Qiu, 2012

Areas of Focus

Mechanisms of transmembrane transport proteins and drug development research
Important metabolic transport proteins related to major diseases and their research potential as drug targets

Publications

Structure and mechanism of the alkane-oxidizing enzyme AlkB, Xue Guo, Jianxiu Zhang, Lei Han, Juliet Lee, Shoshana C Williams, Allison Forsberg, Yan Xu, Rachel Narehood Austin, Liang Feng, 2023
Structure and mechanism of the SGLT family of glucose transporters, Lei Han, Qianhui Qu, Deniz Aydin, Ouliana Panova, Michael J Robertson, Yan Xu, Ron O Dror, Georgios Skiniotis, Liang Feng, 2022
Molecular mechanism of substrate recognition and transport by the AtSWEET13 sugar transporter, Lei Han, Yongping Zhu, Min Liu, Ye Zhou, Guangyuan Lu, Lan Lan, Xianping Wang, Yongfang Zhao, Xuejun C Zhang, 2017
Energy coupling mechanisms of AcrB-like RND transporters, Xuejun C Zhang, Min Liu, Lei Han, 2017
The asparagine-rich protein NRP interacts with the Verticillium effector PevD1 and regulates the subcellular localization of cryptochrome 2, Ruimin Zhou, Tong Zhu, Lei Han, Mengjie Liu, Mengyuan Xu, Yanli Liu, Dandan Han, Dewen Qiu, Qingqiu Gong, Xinqi Liu, 2017
Uniporter substrate binding and transport: reformulating mechanistic questions, Xuejun C Zhang, Lei Han, 2016
How does a beta-barrel integral membrane protein insert into the membrane?, Xuejun C Zhang, Lei Han, 2016
How does the chemical potential of the substrate drive a uniporter?, Xuejun C Zhang, Lei Han, 2016
Thermodynamics of ABC transporters, Xuejun C Zhang, Lei Han, Yan Zhao, 2016
Purification, crystallization and preliminary X-ray diffraction analysis of the effector protein PevD1 from Verticillium dahliae, Lei Han, Zheng Liu, Xinqi Liu, Dewen Qiu, 2012
Purification and characterization of a novel antimicrobial peptide from Brevibacillus laterosporus strain A60, Jing Zhao, Lihua Guo, Hongmei Zeng, Xiufen Yang, Jingjing Yuan, Huaixing Shi, Yehui Xiong, Mingjia Chen, Lei Han, Dewen Qiu, 2012

Transmembrane Transport Proteins Drug Development Substrate Transport Protein Conformation Membrane Potential Metabolic Transport Disease Association Structural Biology High-Throughput Screening

Cai-Hong Yun - Peking University

Chengpeng Fan - Wuhan University

Bei Li - Fudan University

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