Upload Avatar (500 x 500)
Lei Han
Basic Medical Sciences
Wuhan University
Hubei
Language: Chinese, English
Transmembrane
Transport Proteins
Drug Development
Substrate Transport
Protein Conformation
Membrane Potential
Metabolic Transport
Disease Association
Structural Biology
High-Throughput Screening
Areas of Focus
- Mechanisms of transmembrane transport proteins and drug development research
- Important metabolic transport proteins related to major diseases and their research potential as drug targets
Work Experience
- 2017-2023 Postdoctoral Researcher, Department of Molecular and Cellular Physiology, Stanford University
- 2023-present Professor, Taikang School of Medicine (Basic Medical College), Wuhan University, PI at Taikang Life Medical Center
Academic Background & Achievements
- 2005-2009 Bachelor in Bioengineering, Beijing University of Chemical Technology
- 2009-2012 Master in Biochemistry and Molecular Biology, Chinese Academy of Agricultural Sciences
- 2012-2017 PhD in Biochemistry and Molecular Biology, Institute of Biophysics, Chinese Academy of Sciences
Publications
- Structure and mechanism of the alkane-oxidizing enzyme AlkB, Xue Guo, Jianxiu Zhang, Lei Han, Juliet Lee, Shoshana C Williams, Allison Forsberg, Yan Xu, Rachel Narehood Austin, Liang Feng, 2023
- Structure and mechanism of the SGLT family of glucose transporters, Lei Han, Qianhui Qu, Deniz Aydin, Ouliana Panova, Michael J Robertson, Yan Xu, Ron O Dror, Georgios Skiniotis, Liang Feng, 2022
- Molecular mechanism of substrate recognition and transport by the AtSWEET13 sugar transporter, Lei Han, Yongping Zhu, Min Liu, Ye Zhou, Guangyuan Lu, Lan Lan, Xianping Wang, Yongfang Zhao, Xuejun C Zhang, 2017
- Energy coupling mechanisms of AcrB-like RND transporters, Xuejun C Zhang, Min Liu, Lei Han, 2017
- The asparagine-rich protein NRP interacts with the Verticillium effector PevD1 and regulates the subcellular localization of cryptochrome 2, Ruimin Zhou, Tong Zhu, Lei Han, Mengjie Liu, Mengyuan Xu, Yanli Liu, Dandan Han, Dewen Qiu, Qingqiu Gong, Xinqi Liu, 2017
- Uniporter substrate binding and transport: reformulating mechanistic questions, Xuejun C Zhang, Lei Han, 2016
- How does a beta-barrel integral membrane protein insert into the membrane?, Xuejun C Zhang, Lei Han, 2016
- How does the chemical potential of the substrate drive a uniporter?, Xuejun C Zhang, Lei Han, 2016
- Thermodynamics of ABC transporters, Xuejun C Zhang, Lei Han, Yan Zhao, 2016
- Purification, crystallization and preliminary X-ray diffraction analysis of the effector protein PevD1 from Verticillium dahliae, Lei Han, Zheng Liu, Xinqi Liu, Dewen Qiu, 2012
- Purification and characterization of a novel antimicrobial peptide from Brevibacillus laterosporus strain A60, Jing Zhao, Lihua Guo, Hongmei Zeng, Xiufen Yang, Jingjing Yuan, Huaixing Shi, Yehui Xiong, Mingjia Chen, Lei Han, Dewen Qiu, 2012
Awards
- Dean's Postdoctoral Fellowship, School of Medicine, Stanford University (2019)
- National Talent Program Awardee
