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韩蕾
Basic Medical Sciences
武汉大学
湖北省
Language: 中文, 英语
跨膜
转运蛋白
药物开发
底物转运
蛋白构象
膜电位
代谢转运
疾病关联
结构生物学
高通量筛选
Areas of Focus
- 跨膜转运蛋白转运调控机制以及药物开发研究
- 与重大疾病相关的重要代谢物转运蛋白，药物靶点研究潜力
Work Experience
- 2017-2023 斯坦福大学 分子细胞生理系 博士后
- 2023-至今 武汉大学泰康医学院（基础医学院）教授，泰康生命医学中心PI
Academic Background & Achievements
- 2005-2009 北京化工大学 生命科学与技术学院 生物工程专业 本科生
- 2009-2012 中国农业科学院植物保护研究所 生物化学与分子生物学专业 硕士研究生
- 2012-2017 中国科学院生物物理研究所 生物化学与分子生物学专业 博士研究生
Publications
- Structure and mechanism of the alkane-oxidizing enzyme AlkB, Xue Guo, Jianxiu Zhang, Lei Han, Juliet Lee, Shoshana C Williams, Allison Forsberg, Yan Xu, Rachel Narehood Austin, Liang Feng, 2023
- Structure and mechanism of the SGLT family of glucose transporters, Lei Han, Qianhui Qu, Deniz Aydin, Ouliana Panova, Michael J Robertson, Yan Xu, Ron O Dror, Georgios Skiniotis, Liang Feng, 2022
- Molecular mechanism of substrate recognition and transport by the AtSWEET13 sugar transporter, Lei Han, Yongping Zhu, Min Liu, Ye Zhou, Guangyuan Lu, Lan Lan, Xianping Wang, Yongfang Zhao, Xuejun C Zhang, 2017
- Energy coupling mechanisms of AcrB-like RND transporters, Xuejun C Zhang, Min Liu, Lei Han, 2017
- The asparagine-rich protein NRP interacts with the Verticillium effector PevD1 and regulates the subcellular localization of cryptochrome 2, Ruimin Zhou, Tong Zhu, Lei Han, Mengjie Liu, Mengyuan Xu, Yanli Liu, Dandan Han, Dewen Qiu, Qingqiu Gong, Xinqi Liu, 2017
- Uniporter substrate binding and transport: reformulating mechanistic questions, Xuejun C Zhang, Lei Han, 2016
- How does a beta-barrel integral membrane protein insert into the membrane?, Xuejun C Zhang, Lei Han, 2016
- How does the chemical potential of the substrate drive a uniporter?, Xuejun C Zhang, Lei Han, 2016
- Thermodynamics of ABC transporters, Xuejun C Zhang, Lei Han, Yan Zhao, 2016
- Purification, crystallization and preliminary X-ray diffraction analysis of the effector protein PevD1 from Verticillium dahliae, Lei Han, Zheng Liu, Xinqi Liu, Dewen Qiu, 2012
- Purification and characterization of a novel antimicrobial peptide from Brevibacillus laterosporus strain A60, Jing Zhao, Lihua Guo, Hongmei Zeng, Xiufen Yang, Jingjing Yuan, Huaixing Shi, Yehui Xiong, Mingjia Chen, Lei Han, Dewen Qiu, 2012
Awards
- 斯坦福大学医学院院长博士后奖学金 (2019)
- 国家级人才计划入选者
