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Zheng-Guo He
Basic Medical Sciences
Wuhan University
Hubei
Language: Chinese, English
Pathogenic Bacteria
Resistance
Regulation
Growth
Mechanisms
Phage
Synthetic Biology
Mycobacterium Tuberculosis
Protein Interaction Networks
Gene Transcription Networks
Areas of Focus
- Pathogenic bacteria growth resistance regulation mechanisms
- Phage synthetic biology
Work Experience
- 2001-2004 Postdoctoral Researcher, Department of Biochemistry and Molecular Pharmacology, Harvard Medical School
- 2004-2005 Professor and Doctoral Supervisor, College of Life Sciences, Hubei University
- 2005-2019 Various roles including Second-level Professor, Director of Proteomics Research Center, Vice Dean, Vice Director of the National Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University
- 2019-2024 Various roles including Second-level Professor, Distinguished Professor of Guangxi Bagui Scholars, Director of the National Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, Dean of the College of Life Science and Technology, Guangxi University
- 2024-Present Distinguished Professor, Principal Investigator at Taikang Life Medical Center, Second-level Professor at Taikang Medical College (Basic Medical College), Wuhan University
Academic Background & Achievements
- 1988-1992 Bachelor in Microbiology, Huazhong Agricultural University
- 1992-1995 Master in Microbiology, Huazhong Agricultural University
- 1998-2001 PhD in Microbiology, Institute of Microbiology, Chinese Academy of Sciences
Publications
- Insertion sequence transposition activates anti-mycobacteriophage immunity through a lsr2-silenced lipid metabolism gene island, Yakun Li, Yuyun Wei, Xiao Guo, Xiaohui Li, Lining Lu, Lihua Hu, Zheng-Guo He*, 2024
- Mycobacterial phage TM4 requires a eukaryotic-like Ser/Thr protein kinase to silence and escape anti-phage immunity, Xiaohui Li, Xiating Long, Liu Chen, Xiao Guo, Lining Lu, Lihua Hu, Zheng-Guo He*, 2023
- Cyclic di-GMP triggers the hypoxic adaptation of Mycobacterium bovis through a metabolic switching regulator ArgR, Jiaxun Zhang, Lihua Hu, Hua Zhang, Zheng-Guo He*, 2022
- Cyclic di-GMP integrates functionally divergent transcription factors into a regulation pathway for antioxidant defense, Weihui Li, Lihua Hu, Zhiwei Xie, Hui Xu, Meng Li, Tao Cui, Zheng-Guo He*, 2018
- HpoR, a novel c-di-GMP effective transcription factor, links the second messenger’s regulatory function to the mycobacterial antioxidant defense, Weihui Li, Meng Li, Lihua Hu, Jingpeng Zhu, Zhiwei Xie, Jiarui Chen, Zheng-Guo He*, 2018
- NapM, a new nucleoid-associated protein, broadly regulates gene expression and affects mycobacterial resistance to anti-tuberculosis drugs, Yu Liu, Hongyang Wang, Tao Cui, Xiling Zhou, Yanxia Jia, Hua Zhang*, Zheng-Guo He*, 2016
- Cyclic diguanylate monophosphate directly binds to human siderocalin and inhibits its antibacterial activity, Weihui Li, Zheng-Guo He*, 2015
- LtmA, a novel cyclic di-GMP responsive activator, broadly regulates the expression of lipid transport and metabolism genes in Mycobacterium smegmatis, Weihui Li, Zheng-Guo He*, 2012
- A TetR-like regulator broadly affects the expressions of diverse genes in Mycobacterium smegmatis, Min Yang, Chunhui Gao, Tao Cui, Jingning An, Zheng-Guo He*, 2012
- Characterization of an interplay between a Mycobacterium tuberculosis MazF homolog, Rv1495, and its sole DNA topoisomerase I, Feng Huang, Zheng-Guo He*, 2010
Awards
- 2010 National Outstanding Youth Science Fund Award
- 2013 Special Professor of the Ministry of Education Major Talent Project
- 2016 National Major Talent Plan Science and Technology Innovation Leader
- 2014 Ministry of Science and Technology Mid-Young Science and Technology Innovation Leader
- 2013 Special Government Allowance Expert of the State Council
- 2010 National Excellent Science and Technology Worker
- 2012 National Agricultural Research Outstanding Talent of the Ministry of Agriculture
- 2006 New Century Excellent Talents Support Plan of the Ministry of Education
- 2013 Second Prize of the Ministry of Education for Outstanding Scientific Research Achievements (Natural Science)
- 2012 First Batch of High-end Talent Leading Training Plan of Hubei Province Major Talent Engineering
- 2009 Hubei Province Chutian Scholar Distinguished Professor
- 2014 Second Prize of Natural Science of Hubei Province
- 2013 Wuhan Europe-America Alumni Association Study Abroad Contribution Award
