Professor | Zheng-Guo He | Asia Growth Partners

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Name	Zheng-Guo He
Contact Information	hezhengguo2024@whu.edu.cn
Language ability	Chinese, English
Province	Hubei

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Name

Zheng-Guo He

Contact Information

hezhengguo2024@whu.edu.cn

Language ability

Chinese, English

Province

Hubei

University/Lab Affiliation and Title	Wuhan University
Faculty	Basic Medical Sciences
Academic Background & Achievements	1988-1992 Bachelor in Microbiology, Huazhong Agricultural University 1992-1995 Master in Microbiology, Huazhong Agricultural University 1998-2001 PhD in Microbiology, Institute of Microbiology, Chinese Academy of Sciences
Work Experience	2001-2004 Postdoctoral Researcher, Department of Biochemistry and Molecular Pharmacology, Harvard Medical School 2004-2005 Professor and Doctoral Supervisor, College of Life Sciences, Hubei University 2005-2019 Various roles including Second-level Professor, Director of Proteomics Research Center, Vice Dean, Vice Director of the National Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University 2019-2024 Various roles including Second-level Professor, Distinguished Professor of Guangxi Bagui Scholars, Director of the National Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, Dean of the College of Life Science and Technology, Guangxi University 2024-Present Distinguished Professor, Principal Investigator at Taikang Life Medical Center, Second-level Professor at Taikang Medical College (Basic Medical College), Wuhan University
Awards	2010 National Outstanding Youth Science Fund Award 2013 Special Professor of the Ministry of Education Major Talent Project 2016 National Major Talent Plan Science and Technology Innovation Leader 2014 Ministry of Science and Technology Mid-Young Science and Technology Innovation Leader 2013 Special Government Allowance Expert of the State Council 2010 National Excellent Science and Technology Worker 2012 National Agricultural Research Outstanding Talent of the Ministry of Agriculture 2006 New Century Excellent Talents Support Plan of the Ministry of Education 2013 Second Prize of the Ministry of Education for Outstanding Scientific Research Achievements (Natural Science) 2012 First Batch of High-end Talent Leading Training Plan of Hubei Province Major Talent Engineering 2009 Hubei Province Chutian Scholar Distinguished Professor 2014 Second Prize of Natural Science of Hubei Province 2013 Wuhan Europe-America Alumni Association Study Abroad Contribution Award

University/Lab Affiliation and Title

Wuhan University

Faculty

Basic Medical Sciences

Academic Background & Achievements

1988-1992 Bachelor in Microbiology, Huazhong Agricultural University
1992-1995 Master in Microbiology, Huazhong Agricultural University
1998-2001 PhD in Microbiology, Institute of Microbiology, Chinese Academy of Sciences

Work Experience

2001-2004 Postdoctoral Researcher, Department of Biochemistry and Molecular Pharmacology, Harvard Medical School
2004-2005 Professor and Doctoral Supervisor, College of Life Sciences, Hubei University
2005-2019 Various roles including Second-level Professor, Director of Proteomics Research Center, Vice Dean, Vice Director of the National Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University
2019-2024 Various roles including Second-level Professor, Distinguished Professor of Guangxi Bagui Scholars, Director of the National Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, Dean of the College of Life Science and Technology, Guangxi University
2024-Present Distinguished Professor, Principal Investigator at Taikang Life Medical Center, Second-level Professor at Taikang Medical College (Basic Medical College), Wuhan University

Awards

2010 National Outstanding Youth Science Fund Award
2013 Special Professor of the Ministry of Education Major Talent Project
2016 National Major Talent Plan Science and Technology Innovation Leader
2014 Ministry of Science and Technology Mid-Young Science and Technology Innovation Leader
2013 Special Government Allowance Expert of the State Council
2010 National Excellent Science and Technology Worker
2012 National Agricultural Research Outstanding Talent of the Ministry of Agriculture
2006 New Century Excellent Talents Support Plan of the Ministry of Education
2013 Second Prize of the Ministry of Education for Outstanding Scientific Research Achievements (Natural Science)
2012 First Batch of High-end Talent Leading Training Plan of Hubei Province Major Talent Engineering
2009 Hubei Province Chutian Scholar Distinguished Professor
2014 Second Prize of Natural Science of Hubei Province
2013 Wuhan Europe-America Alumni Association Study Abroad Contribution Award

Areas of Focus	Pathogenic bacteria growth resistance regulation mechanisms Phage synthetic biology
Publications	Insertion sequence transposition activates anti-mycobacteriophage immunity through a lsr2-silenced lipid metabolism gene island, Yakun Li, Yuyun Wei, Xiao Guo, Xiaohui Li, Lining Lu, Lihua Hu, Zheng-Guo He, 2024 Mycobacterial phage TM4 requires a eukaryotic-like Ser/Thr protein kinase to silence and escape anti-phage immunity, Xiaohui Li, Xiating Long, Liu Chen, Xiao Guo, Lining Lu, Lihua Hu, Zheng-Guo He, 2023 Cyclic di-GMP triggers the hypoxic adaptation of Mycobacterium bovis through a metabolic switching regulator ArgR, Jiaxun Zhang, Lihua Hu, Hua Zhang, Zheng-Guo He, 2022 Cyclic di-GMP integrates functionally divergent transcription factors into a regulation pathway for antioxidant defense, Weihui Li, Lihua Hu, Zhiwei Xie, Hui Xu, Meng Li, Tao Cui, Zheng-Guo He, 2018 HpoR, a novel c-di-GMP effective transcription factor, links the second messenger’s regulatory function to the mycobacterial antioxidant defense, Weihui Li, Meng Li, Lihua Hu, Jingpeng Zhu, Zhiwei Xie, Jiarui Chen, Zheng-Guo He, 2018 NapM, a new nucleoid-associated protein, broadly regulates gene expression and affects mycobacterial resistance to anti-tuberculosis drugs, Yu Liu, Hongyang Wang, Tao Cui, Xiling Zhou, Yanxia Jia, Hua Zhang, Zheng-Guo He, 2016 Cyclic diguanylate monophosphate directly binds to human siderocalin and inhibits its antibacterial activity, Weihui Li, Zheng-Guo He, 2015 LtmA, a novel cyclic di-GMP responsive activator, broadly regulates the expression of lipid transport and metabolism genes in Mycobacterium smegmatis, Weihui Li, Zheng-Guo He, 2012 A TetR-like regulator broadly affects the expressions of diverse genes in Mycobacterium smegmatis, Min Yang, Chunhui Gao, Tao Cui, Jingning An, Zheng-Guo He, 2012 Characterization of an interplay between a Mycobacterium tuberculosis MazF homolog, Rv1495, and its sole DNA topoisomerase I, Feng Huang, Zheng-Guo He*, 2010

Areas of Focus

Pathogenic bacteria growth resistance regulation mechanisms
Phage synthetic biology

Publications

Insertion sequence transposition activates anti-mycobacteriophage immunity through a lsr2-silenced lipid metabolism gene island, Yakun Li, Yuyun Wei, Xiao Guo, Xiaohui Li, Lining Lu, Lihua Hu, Zheng-Guo He*, 2024
Mycobacterial phage TM4 requires a eukaryotic-like Ser/Thr protein kinase to silence and escape anti-phage immunity, Xiaohui Li, Xiating Long, Liu Chen, Xiao Guo, Lining Lu, Lihua Hu, Zheng-Guo He*, 2023
Cyclic di-GMP triggers the hypoxic adaptation of Mycobacterium bovis through a metabolic switching regulator ArgR, Jiaxun Zhang, Lihua Hu, Hua Zhang, Zheng-Guo He*, 2022
Cyclic di-GMP integrates functionally divergent transcription factors into a regulation pathway for antioxidant defense, Weihui Li, Lihua Hu, Zhiwei Xie, Hui Xu, Meng Li, Tao Cui, Zheng-Guo He*, 2018
HpoR, a novel c-di-GMP effective transcription factor, links the second messenger’s regulatory function to the mycobacterial antioxidant defense, Weihui Li, Meng Li, Lihua Hu, Jingpeng Zhu, Zhiwei Xie, Jiarui Chen, Zheng-Guo He*, 2018
NapM, a new nucleoid-associated protein, broadly regulates gene expression and affects mycobacterial resistance to anti-tuberculosis drugs, Yu Liu, Hongyang Wang, Tao Cui, Xiling Zhou, Yanxia Jia, Hua Zhang*, Zheng-Guo He*, 2016
Cyclic diguanylate monophosphate directly binds to human siderocalin and inhibits its antibacterial activity, Weihui Li, Zheng-Guo He*, 2015
LtmA, a novel cyclic di-GMP responsive activator, broadly regulates the expression of lipid transport and metabolism genes in Mycobacterium smegmatis, Weihui Li, Zheng-Guo He*, 2012
A TetR-like regulator broadly affects the expressions of diverse genes in Mycobacterium smegmatis, Min Yang, Chunhui Gao, Tao Cui, Jingning An, Zheng-Guo He*, 2012
Characterization of an interplay between a Mycobacterium tuberculosis MazF homolog, Rv1495, and its sole DNA topoisomerase I, Feng Huang, Zheng-Guo He*, 2010

Pathogenic Bacteria Resistance Regulation Growth Mechanisms Phage Synthetic Biology Mycobacterium Tuberculosis Protein Interaction Networks Gene Transcription Networks

Gao Yan - Capital Medical University

Dan Zhou - Nanjing Medical University

Cong Xin - Peking University

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