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Tan Yueqiu
Basic Medical Sciences
Central South University
Hunan
Language: Chinese, English
Genetics
Gametogenesis
Azoospermia
Oligospermia
Ovarian Failure
Gene Screening
Functional Analysis
Genetic Diseases
Prenatal Diagnosis
Genetic Testing
Areas of Focus
- Medical Genetics: New gene screening and functional analysis for gametogenesis disorders (azoospermia, oligospermia, and premature ovarian failure)
- Clinical Genetics: Diagnosis of genetic diseases, prenatal diagnosis, and pre-implantation genetic testing
Work Experience
- 1991.7-1993.2: Intern Researcher, National Key Laboratory of Medical Genetics, Hunan Medical University
- 2002.9-present: Associate Researcher (2002), Researcher (2007), Reproductive and Stem Cell Engineering Institute, Central South University
Academic Background & Achievements
- 1991-1997: Bachelor of Biology, Hunan Normal University
- 1997-2002: Master and PhD in Medical Genetics, Hunan Medical University and Central South University
- Key project leader in national key R&D programs and fundamental research programs
- Recipient of the National Science and Technology Progress Second Prize
- Recipient of the First Prize of Scientific and Technological Progress by the Ministry of Education
Publications
- Defective piRNA Processing and Azoospermia, Wang X, Tan YQ, Liu MF, 2022
- Loss-of-function variants in human C12orf40 cause male infertility by blocking meiotic progression, Tu C, Wen J, Wang W, Zhu Q, Chen Y, Cheng J, Li Z, Meng L, Li Y, He W, Tan C, Xie C, Fu S, Du J, Lu G, Lin G, Gou LT, Tan YQ, 2023
- DRC3 is an assembly adapter of the nexin-dynein regulatory complex functional components during spermatogenesis in humans and mice, Zhou S, Yuan S, Zhang J, Meng L, Zhang X, Liu S, Lu G, Lin G, Liu M, Tan YQ, 2023
- Bi-allelic variants in human WDR63 cause male infertility via abnormal inner dynein arms assembly, Lu S, Gu Y, Wu Y, Yang S, Li C, Meng L, Yuan W, Jiang T, Zhang X, Li Y, Wang C, Liu M, Ye L, Guo X, Shen H, Yang X, Tan Y, Hu Z, 2021
- Bi-allelic mutations of DNAH10 cause primary male infertility with asthenoteratozoospermia in humans and mice, Tu C, Cong J, Zhang Q, He X, Zheng R, Yang X, Gao Y, Wu H, Lv M, Gu Y, Lu S, Liu C, Tian S, Meng L, Wang W, Tan C, Nie H, Li D, Zhang H, Gong F, Hu L, Lu G, Xu W, Lin G, Zhang F, Cao Y, Tan YQ, 2021
- TDRD7 participates in lens development and spermiogenesis by mediating autophagosome maturation, Tu C, Li H, Liu X, Wang Y, Li W, Meng L, Wang W, Li Y, Li D, Du J, Lu G, Lin G, Tan YQ, 2021
- Deleterious variants in X-linked CFAP47 induce asthenoteratozoospermia and primary male infertility, Liu C, Tu C, Wang L, Wu H, Houston BJ, Mastrorosa FK, Zhang W, Shen Y, Wang J, Tian S, Meng L, Cong J, Yang S, Jiang Y, Tang S, Zeng Y, Lv M, Lin G, Li J, Saiyin H, He X, Jin L, Touré A, Ray PF, Veltman JA, Shi Q, O'Bryan MK, Cao Y, Tan YQ, Zhang F, 2021
- Bi-allelic variants in DNHD1 cause flagellar axoneme defects and asthenoteratozoospermia in humans and mice, Tan C, Meng L, Lv M, He X, Sha Y, Tang D, Tan Y, Hu T, He W, Tu C, Nie H, Zhang H, Du J, Lu G, Fan LQ, Cao Y, Lin G, Tan YQ, 2022
- Meiotic recombination: insights into its mechanisms and its role in human reproduction with a special focus on non-obstructive azoospermia, Xie C, Wang W, Tu C, Meng L, Lu G, Lin G, Lu LY, Tan YQ, 2022
- Deficiency of primate-specific SSX1 induced asthenoteratozoospermia in infertile men and cynomolgus monkey and tree shrew models, Liu C, Si W, Tu C, Tian S, He X, Wang S, Yang X, Yao C, Li C, Kherraf ZE, Ye M, Zhou Z, Ma Y, Gao Y, Li Y, Liu Q, Tang S, Wang J, Saiyin H, Zhao L, Yang L, Meng L, Chen B, Tang D, Zhou Y, Wu H, Lv M, Tan C, Lin G, Kong Q, Shi H, Su Z, Li Z, Yao YG, Jin L, Zheng P, Ray PF, Tan YQ, Cao Y, Zhang F, 2023
- Loss-of-function mutations TDRD7 lead to a rare novel syndrome combining congenital cataract and non-obstructive azoospermia in humans, Tan YQ, Tu CF, Meng LL, Yuan SM, Sjaarda C, Luo AX, Du J, Li W, Gong F, Zhong CG, Deng HX, Lu GX, Liang P, Lin G, 2019
- Biallelic CFAP61 variants cause male infertility in humans and mice with severe oligoasthenoteratozoospermia, Hu T, Meng L, Tan C, Luo C, He WB, Tu C, Zhang H, Du J, Nie H, Lu GX, Lin G, Tan YQ, 2023
- Biallelic variants in KCTD19 associated with male factor infertility and oligoasthenoteratozoospermia, Wang W, Su L, Meng L, He J, Tan C, Yi D, Cheng D, Zhang H, Lu G, Du J, Lin G, Zhang Q, Tu C, Tan YQ, 2023
- A homozygous RPL10L missense mutation associated with male factor infertility and severe oligozoospermia, Tu C, Meng L, Nie H, Yuan S, Wang W, Du J, Lu G, Lin G, Tan YQ, 2020
- Homozygous variants in SYCP2L cause premature ovarian insufficiency, He WB, Tan C, Zhang YX, Meng LL, Gong F, Lu GX, Lin G, Du J, Tan YQ, 2021
- CFAP65 is required in the acrosome biogenesis and mitochondrial sheath assembly during spermiogenesis, Wang W, Tian S, Nie H, Tu C, Liu C, Li Y, Li D, Yang X, Meng L, Hu T, Zhang Q, Du J, Fan L, Lu G, Lin G, Zhang F, Tan YQ, 2021
Awards
- 2006: Hunan Province Youth Key Teacher
- 2013: Hunan Province Medical Science Key Talent
- 2019: Leader of Hunan Province Medical Genetics Discipline
