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Haocheng Lu
Medical School
Southern University of Science and Technology
Guangdong
Language: English, Chinese
Gwas
Multi-Omics
Cardiovascular Diseases
In Vitro Experiments
Animal Models
Crispr Screening
Macrophages
Disease Development
Translational Medicine
Therapeutic Targets
Areas of Focus
- Discovery of pathogenic genes for cardiovascular diseases based on GWAS and multi-omics data, combined with in vitro experiments and animal models
- Utilization of in vivo CRISPR screening to discover key regulatory genes involved in disease development by macrophages
- Exploration of the translational medical value of newly discovered pathogenic genes, development of new therapeutic targets
Work Experience
- 2019-2022 Postdoctoral Research Fellow, University of Michigan Medical School
- 2022-present Assistant Professor, Southern University of Science and Technology
Academic Background & Achievements
- 2008-2014 Bachelor in Clinical Medicine: Peking University
- 2008-2014 Bachelor in Economics (Dual Degree): National Development Research Institute, Peking University
- 2014-2019 PhD in Physiology: University of Michigan
Publications
- RNA sequencing reveals perivascular adipose tissue plasticity in response to angiotensin II, Wang Z*, Lu H*, Garcia-Barrio M, Guo Y, Zhang J, Chen YE, Chang L, 2022
- Vascular Smooth Muscle Cells in Aortic Aneurysm: From Genetics to Mechanisms, Lu H, Du W, Ren L, Hamblin MH, Becker RC, Chen YE, Fan Y, 2021
- Type 2 diabetes sex-specific effects associated with E167K coding variant in TM6SF2, Fan Y*, Wolford BN*, Lu H*, Liang W, Sun J, Zhou W, Rom O, Mahajan A, Surakka I, Graham SE, Liu Z, Kim H, Ramdas S, Fritsche LG, Nielsen JB, Gabrielsen ME, Hveem K, Yang D, Song J, Garcia-Barrio MT, Zhang J, Liu W, Zhang K, Willer CJ, Chen YE, 2021
- Regulatory variants in TCF7L2 are associated with thoracic aortic aneurysm, Roychowdhury T*, Lu H*, Hornsby WE, Crone B, Wang GT, Guo DC, Sendamarai AK, Devineni P, Lin M, Zhou W, Graham SE, Wolford BN, Surakka I, Wang Z, Chang L, Zhang J, Mathis M, Brummett CM, Melendez TL, Shea MJ, Kim KM, Deeb GM, Patel HJ, Eliason J, Eagle KA, Yang B, Ganesh SK, Brumpton B, Åsvold BO, Skogholt AH, Hveem K, Pyarajan S, Klarin D, Tsao PS, Damrauer SM, Leal SM, Milewicz DM, Chen YE, Garcia-Barrio MT, Willer CJ, 2021
- Integration of Transformative Platforms for the Discovery of Causative Genes in Cardiovascular Diseases, Lu H, Zhang J, Chen YE, Garcia-Barrio MT, 2021
- Transcription factor EB regulates cardiovascular homeostasis, Lu H, Sun J, Hamblin MH, Chen YE, Fan Y, 2021
- Cyclodextrin Prevents Abdominal Aortic Aneurysm via Activation of Vascular Smooth Muscle Cell Transcription Factor EB, Lu H, Sun J, Liang W, Zhang J, Rom O, Garcia-Barrio MT, Li S, Villacorta L, Schopfer FJ, Freeman BA, Chen YE, Fan Y, 2020
- Novel gene regulatory networks identified in response to nitro-conjugated linoleic acid in human endothelial cells, Lu H, Sun J, Liang W, Zhang J, Rom O, Garcia-Barrio MT, Li S, Villacorta L, Schopfer FJ, Freeman BA, Chen YE, Fan Y, 2019
- TFEB inhibits endothelial cell inflammation and reduces atherosclerosis, Lu H, Fan Y, Qiao C, Liang W, Hu W, Zhu T, Zhang J, Chen YE, 2017
Awards
- 2016-2018 Predoctoral fellowship: American Heart Association
- 2018 Young Investigator Award: Chinese American Academy of Cardiology, Chinese Society for Vascular Medicine
