Professor | Shuai Shimin | Asia Growth Partners

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Name	Shuai Shimin
Contact Information	shuaism@sustech.edu.cn
Language ability	English, Chinese
Province	Guangdong

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Name

Shuai Shimin

Contact Information

shuaism@sustech.edu.cn

Language ability

English, Chinese

Province

Guangdong

University/Lab Affiliation and Title	Southern University of Science and Technology
Faculty	Medical School
Academic Background & Achievements	2014-2019: PhD in Computational Biology, University of Toronto, Canada 2010-2014: Bachelor in Biological Sciences, Zhejiang University, China
Work Experience	2022.6-present: Associate Professor, Department of Human Cell Biology and Genetics, School of Medicine, Southern University of Science and Technology, China 2021.9-2022.5: Assistant Professor, Department of Human Cell Biology and Genetics, School of Medicine, Southern University of Science and Technology, China 2020.10-2021.8: Joint Postdoctoral Researcher, European Bioinformatics Institute (EMBL-EBI), UK 2020.1-2021.8: EIPOD4 Postdoctoral Fellow (co-funded by Marie Skłodowska-Curie Actions), European Molecular Biology Laboratory (EMBL), Germany 2015.1-2019.11: PhD Researcher, Ontario Institute for Cancer Research (OICR), Canada
Awards	2021: Shenzhen High-level Talent (National Leading Talent) 2020: EMBL Interdisciplinary Postdoctoral Fellowship (EIPOD4) co-funded by Marie-Skłodowska Curie Actions 2019: Canadian Cancer Society Travel Award

University/Lab Affiliation and Title

Southern University of Science and Technology

Faculty

Medical School

Academic Background & Achievements

2014-2019: PhD in Computational Biology, University of Toronto, Canada
2010-2014: Bachelor in Biological Sciences, Zhejiang University, China

Work Experience

2022.6-present: Associate Professor, Department of Human Cell Biology and Genetics, School of Medicine, Southern University of Science and Technology, China
2021.9-2022.5: Assistant Professor, Department of Human Cell Biology and Genetics, School of Medicine, Southern University of Science and Technology, China
2020.10-2021.8: Joint Postdoctoral Researcher, European Bioinformatics Institute (EMBL-EBI), UK
2020.1-2021.8: EIPOD4 Postdoctoral Fellow (co-funded by Marie Skłodowska-Curie Actions), European Molecular Biology Laboratory (EMBL), Germany
2015.1-2019.11: PhD Researcher, Ontario Institute for Cancer Research (OICR), Canada

Awards

2021: Shenzhen High-level Talent (National Leading Talent)
2020: EMBL Interdisciplinary Postdoctoral Fellowship (EIPOD4) co-funded by Marie-Skłodowska Curie Actions
2019: Canadian Cancer Society Travel Award

Areas of Focus	Bioinformatics and Computational Biology Full-scale Genetic Variants and Association with Human Diseases RNA Splicing Abnormalities and Association with Human Diseases Disease Ecosystem Research Multi-omics Data Analysis and Development of Novel Omics Data Analysis Tools
Publications	Combined burden and functional impact tests for cancer driver discovery using DriverPower, Shuai S, PCAWG Drivers and Functional Interpretation Working Group, Gallinger S, Stein LD & PCAWG Consortium, 2020 The U1 spliceosomal RNA is recurrently mutated in multiple cancers, Shuai S, Suzuki H, Diaz-Navarro A, Nadeu F, Kumar SA, Gutierrez-Fernandez A, Delgado J, Pinyol M, López-Otín C, Puente XS, Taylor MD, Campo E & Stein LD, 2019 Analyses of non-coding somatic drivers in 2,658 cancer whole genomes, Rheinbay E, Nielsen MM, Abascal F, Wala JA, Shapira O, Tiao G, Hornshøj H, Hess JM, Juul RI, Lin Z, Feuerbach L, Sabarinathan R, Madsen T, Kim J, Mularoni L, Shuai S, Lanzós A, Herrmann C, Maruvka YE, Shen C, et al, 2020 Candidate Cancer Driver Mutations in Distal Regulatory Elements and Long-Range Chromatin Interaction Networks, Zhu H, Uusküla-Reimand L, Isaev K, Wadi L, Alizada A, Shuai S, Huang V, Aduluso-Nwaobasi D, Paczkowska M, Abd-Rabbo D, Ocsenas O, Liang M, Thompson JD, Li Y, Ruan L, Krassowski M, Dzneladze I, Simpson JT, Lupien M, Stein LD, et al, 2020 Recurrent noncoding U1 snRNA mutations drive cryptic splicing in SHH medulloblastoma, Suzuki H, Kumar SA, Shuai S, Diaz-Navarro A, Gutierrez-Fernandez A, De Antonellis P, Cavalli FMG, Juraschka K, Farooq H, Shibahara I, Vladoiu MC, Zhang J, Abeysundara N, Przelicki D, Skowron P, Gauer N, Luu B, Daniels C, Wu X, Forget A, et al, 2019 Recurrent noncoding regulatory mutations in pancreatic ductal adenocarcinoma, Feigin ME, Garvin T, Bailey P, Waddell N, Chang DK, Kelley DR, Shuai S, Gallinger S, McPherson JD, Grimmond SM, Khurana E, Stein LD, Biankin AV, Schatz MC & Tuveson DA, 2017 Pan-cancer analysis of whole genomes, ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium [including Shuai S], 2020 Cancer LncRNA Census reveals evidence for deep functional conservation of long noncoding RNAs in tumorigenesis, Carlevaro-Fita J, Lanzós A, Feuerbach L, Hong C, Mas-Ponte D, Pedersen JS, PCAWG Drivers and Functional Interpretation Group [including Shuai S], Johnson R & PCAWG Consortium, 2020 Integrative pathway enrichment analysis of multivariate omics data, Paczkowska M, Barenboim J, Sintupisut N, Fox NS, Zhu H, Abd-Rabbo D, Mee MW, Boutros PC, PCAWG Drivers and Functional Interpretation Working Group [including Shuai S], Reimand J & PCAWG Consortium, 2020 Pathway and network analysis of more than 2500 whole cancer genomes, Reyna MA, Haan D, Paczkowska M, Verbeke LPC, Vazquez M, Kahraman A, Pulido-Tamayo S, Barenboim J, Wadi L, Dhingra P, Shrestha R, Getz G, Lawrence MS, Pedersen JS, Rubin MA, Wheeler DA, Brunak S, Izarzugaza JMG, Khurana E, Marchal K, et al, PCAWG Drivers and Functional Interpretation Working Group [including Shuai S], Reimand J, Stuart JM, Raphael BJ & PCAWG Consortium, 2020

Areas of Focus

Bioinformatics and Computational Biology
Full-scale Genetic Variants and Association with Human Diseases
RNA Splicing Abnormalities and Association with Human Diseases
Disease Ecosystem Research
Multi-omics Data Analysis and Development of Novel Omics Data Analysis Tools

Publications

Combined burden and functional impact tests for cancer driver discovery using DriverPower, Shuai S*, PCAWG Drivers and Functional Interpretation Working Group, Gallinger S, Stein LD* & PCAWG Consortium, 2020
The U1 spliceosomal RNA is recurrently mutated in multiple cancers, Shuai S, Suzuki H, Diaz-Navarro A, Nadeu F, Kumar SA, Gutierrez-Fernandez A, Delgado J, Pinyol M, López-Otín C, Puente XS, Taylor MD, Campo E & Stein LD, 2019
Analyses of non-coding somatic drivers in 2,658 cancer whole genomes, Rheinbay E, Nielsen MM, Abascal F, Wala JA, Shapira O, Tiao G, Hornshøj H, Hess JM, Juul RI, Lin Z, Feuerbach L, Sabarinathan R, Madsen T, Kim J, Mularoni L, Shuai S, Lanzós A, Herrmann C, Maruvka YE, Shen C, et al, 2020
Candidate Cancer Driver Mutations in Distal Regulatory Elements and Long-Range Chromatin Interaction Networks, Zhu H, Uusküla-Reimand L, Isaev K, Wadi L, Alizada A, Shuai S, Huang V, Aduluso-Nwaobasi D, Paczkowska M, Abd-Rabbo D, Ocsenas O, Liang M, Thompson JD, Li Y, Ruan L, Krassowski M, Dzneladze I, Simpson JT, Lupien M, Stein LD, et al, 2020
Recurrent noncoding U1 snRNA mutations drive cryptic splicing in SHH medulloblastoma, Suzuki H, Kumar SA, Shuai S, Diaz-Navarro A, Gutierrez-Fernandez A, De Antonellis P, Cavalli FMG, Juraschka K, Farooq H, Shibahara I, Vladoiu MC, Zhang J, Abeysundara N, Przelicki D, Skowron P, Gauer N, Luu B, Daniels C, Wu X, Forget A, et al, 2019
Recurrent noncoding regulatory mutations in pancreatic ductal adenocarcinoma, Feigin ME, Garvin T, Bailey P, Waddell N, Chang DK, Kelley DR, Shuai S, Gallinger S, McPherson JD, Grimmond SM, Khurana E, Stein LD, Biankin AV, Schatz MC & Tuveson DA, 2017
Pan-cancer analysis of whole genomes, ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium [including Shuai S], 2020
Cancer LncRNA Census reveals evidence for deep functional conservation of long noncoding RNAs in tumorigenesis, Carlevaro-Fita J, Lanzós A, Feuerbach L, Hong C, Mas-Ponte D, Pedersen JS, PCAWG Drivers and Functional Interpretation Group [including Shuai S], Johnson R & PCAWG Consortium, 2020
Integrative pathway enrichment analysis of multivariate omics data, Paczkowska M, Barenboim J, Sintupisut N, Fox NS, Zhu H, Abd-Rabbo D, Mee MW, Boutros PC, PCAWG Drivers and Functional Interpretation Working Group [including Shuai S], Reimand J & PCAWG Consortium, 2020
Pathway and network analysis of more than 2500 whole cancer genomes, Reyna MA, Haan D, Paczkowska M, Verbeke LPC, Vazquez M, Kahraman A, Pulido-Tamayo S, Barenboim J, Wadi L, Dhingra P, Shrestha R, Getz G, Lawrence MS, Pedersen JS, Rubin MA, Wheeler DA, Brunak S, Izarzugaza JMG, Khurana E, Marchal K, et al, PCAWG Drivers and Functional Interpretation Working Group [including Shuai S], Reimand J, Stuart JM, Raphael BJ & PCAWG Consortium, 2020

Bioinformatics Computational Biology Genetic Variants Human Diseases Rna Splicing Disease Ecosystems Multi-Omics Data Analysis Omics Tools Research

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