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Shuai Shimin
Medical School
Southern University of Science and Technology
Guangdong
Language: English, Chinese
Bioinformatics
Computational Biology
Genetic Variants
Human Diseases
Rna Splicing
Disease Ecosystems
Multi-Omics
Data Analysis
Omics Tools
Research
Areas of Focus
- Bioinformatics and Computational Biology
- Full-scale Genetic Variants and Association with Human Diseases
- RNA Splicing Abnormalities and Association with Human Diseases
- Disease Ecosystem Research
- Multi-omics Data Analysis and Development of Novel Omics Data Analysis Tools
Work Experience
- 2022.6-present: Associate Professor, Department of Human Cell Biology and Genetics, School of Medicine, Southern University of Science and Technology, China
- 2021.9-2022.5: Assistant Professor, Department of Human Cell Biology and Genetics, School of Medicine, Southern University of Science and Technology, China
- 2020.10-2021.8: Joint Postdoctoral Researcher, European Bioinformatics Institute (EMBL-EBI), UK
- 2020.1-2021.8: EIPOD4 Postdoctoral Fellow (co-funded by Marie Skłodowska-Curie Actions), European Molecular Biology Laboratory (EMBL), Germany
- 2015.1-2019.11: PhD Researcher, Ontario Institute for Cancer Research (OICR), Canada
Academic Background & Achievements
- 2014-2019: PhD in Computational Biology, University of Toronto, Canada
- 2010-2014: Bachelor in Biological Sciences, Zhejiang University, China
Publications
- Combined burden and functional impact tests for cancer driver discovery using DriverPower, Shuai S*, PCAWG Drivers and Functional Interpretation Working Group, Gallinger S, Stein LD* & PCAWG Consortium, 2020
- The U1 spliceosomal RNA is recurrently mutated in multiple cancers, Shuai S, Suzuki H, Diaz-Navarro A, Nadeu F, Kumar SA, Gutierrez-Fernandez A, Delgado J, Pinyol M, López-Otín C, Puente XS, Taylor MD, Campo E & Stein LD, 2019
- Analyses of non-coding somatic drivers in 2,658 cancer whole genomes, Rheinbay E, Nielsen MM, Abascal F, Wala JA, Shapira O, Tiao G, Hornshøj H, Hess JM, Juul RI, Lin Z, Feuerbach L, Sabarinathan R, Madsen T, Kim J, Mularoni L, Shuai S, Lanzós A, Herrmann C, Maruvka YE, Shen C, et al, 2020
- Candidate Cancer Driver Mutations in Distal Regulatory Elements and Long-Range Chromatin Interaction Networks, Zhu H, Uusküla-Reimand L, Isaev K, Wadi L, Alizada A, Shuai S, Huang V, Aduluso-Nwaobasi D, Paczkowska M, Abd-Rabbo D, Ocsenas O, Liang M, Thompson JD, Li Y, Ruan L, Krassowski M, Dzneladze I, Simpson JT, Lupien M, Stein LD, et al, 2020
- Recurrent noncoding U1 snRNA mutations drive cryptic splicing in SHH medulloblastoma, Suzuki H, Kumar SA, Shuai S, Diaz-Navarro A, Gutierrez-Fernandez A, De Antonellis P, Cavalli FMG, Juraschka K, Farooq H, Shibahara I, Vladoiu MC, Zhang J, Abeysundara N, Przelicki D, Skowron P, Gauer N, Luu B, Daniels C, Wu X, Forget A, et al, 2019
- Recurrent noncoding regulatory mutations in pancreatic ductal adenocarcinoma, Feigin ME, Garvin T, Bailey P, Waddell N, Chang DK, Kelley DR, Shuai S, Gallinger S, McPherson JD, Grimmond SM, Khurana E, Stein LD, Biankin AV, Schatz MC & Tuveson DA, 2017
- Pan-cancer analysis of whole genomes, ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium [including Shuai S], 2020
- Cancer LncRNA Census reveals evidence for deep functional conservation of long noncoding RNAs in tumorigenesis, Carlevaro-Fita J, Lanzós A, Feuerbach L, Hong C, Mas-Ponte D, Pedersen JS, PCAWG Drivers and Functional Interpretation Group [including Shuai S], Johnson R & PCAWG Consortium, 2020
- Integrative pathway enrichment analysis of multivariate omics data, Paczkowska M, Barenboim J, Sintupisut N, Fox NS, Zhu H, Abd-Rabbo D, Mee MW, Boutros PC, PCAWG Drivers and Functional Interpretation Working Group [including Shuai S], Reimand J & PCAWG Consortium, 2020
- Pathway and network analysis of more than 2500 whole cancer genomes, Reyna MA, Haan D, Paczkowska M, Verbeke LPC, Vazquez M, Kahraman A, Pulido-Tamayo S, Barenboim J, Wadi L, Dhingra P, Shrestha R, Getz G, Lawrence MS, Pedersen JS, Rubin MA, Wheeler DA, Brunak S, Izarzugaza JMG, Khurana E, Marchal K, et al, PCAWG Drivers and Functional Interpretation Working Group [including Shuai S], Reimand J, Stuart JM, Raphael BJ & PCAWG Consortium, 2020
Awards
- 2021: Shenzhen High-level Talent (National Leading Talent)
- 2020: EMBL Interdisciplinary Postdoctoral Fellowship (EIPOD4) co-funded by Marie-Skłodowska Curie Actions
- 2019: Canadian Cancer Society Travel Award
