Professor | Xi Chen | Asia Growth Partners

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Name	Xi Chen
Contact Information	chenx9@sustech.edu.cn
Language ability	English, Chinese
Province	Guangdong

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Name

Xi Chen

Contact Information

chenx9@sustech.edu.cn

Language ability

English, Chinese

Province

Guangdong

University/Lab Affiliation and Title	Southern University of Science and Technology
Faculty	Life Sciences
Academic Background & Achievements	2009 - 2012 PhD: University of Manchester, Life Sciences 2005 - 2009 Bachelor: Peking University, Medical Experimental Science Discovered and elucidated a cancer-promoting transcription factor FOXM1's regulatory mechanism during the G2/M phase of the cell cycle.
Work Experience	2019 - Present - Southern University of Science and Technology, Assistant Professor 2016 - 2019 - Wellcome Sanger Institute, Senior Researcher 2013 - 2016 - European Bioinformatics Institute, Postdoctoral Researcher 2012 - 2013 - University of Manchester, Research Assistant

University/Lab Affiliation and Title

Southern University of Science and Technology

Faculty

Life Sciences

Academic Background & Achievements

2009 - 2012 PhD: University of Manchester, Life Sciences
2005 - 2009 Bachelor: Peking University, Medical Experimental Science
Discovered and elucidated a cancer-promoting transcription factor FOXM1's regulatory mechanism during the G2/M phase of the cell cycle.

Work Experience

2019 - Present - Southern University of Science and Technology, Assistant Professor
2016 - 2019 - Wellcome Sanger Institute, Senior Researcher
2013 - 2016 - European Bioinformatics Institute, Postdoctoral Researcher
2012 - 2013 - University of Manchester, Research Assistant

Areas of Focus	Single-cell epigenetics and transcriptomics sequencing technology development Genomic data mining and bioinformatics analysis Study of transcription factors and chromatin complexes in controlling cell fate determination and memory using T cells and stem cells as models
Publications	Genome-wide CRISPR screens in T helper cells reveal pervasive cross-talk between activation and differentiation, Henriksson, J., Chen, X., Gomes, T., Ullah, U., and Meyer, K.B., 2019 The BAF and PRC2 Complex Subunits Dpf2 and Eed Antagonistically Converge on Tbx3 to Control ESC Differentiation, Zhang, W., Chronis, C., Chen, X., Zhang, H., Spalinskas, R., Pardo, M., Chen, L., Wu, G., Zhu, Z., Yu, Y., et al., 2019 A rapid and robust method for single cell chromatin accessibility profiling, Chen, X., Miragaia, R.J., Natarajan, K.N., and Teichmann, S.A., 2018 Single cell RNA-seq and ATAC-seq analysis of cardiac progenitor cell transition states and lineage settlement, Jia, G., Preussner, J., Chen, X., Guenther, S., Yuan, X., Yekelchyk, M., Kuenne, C., Looso, M., Zhou, Y., Teichmann, S., et al., 2018 Gene expression variability across cells and species shapes innate immunity, Hagai, T., Chen, X., Miragaia, R.J., Rostom, R., Gomes, T., Kunowska, N., Henriksson, J., Park, J.-E., Proserpio, V., Donati, G., et al., 2018 Genome-wide analyses reveal the IRE1a-XBP1 pathway promotes T helper cell differentiation by resolving secretory stress and accelerating proliferation, Pramanik, J., Chen, X., Kar, G., Henriksson, J., Gomes, T., Park, J.-E., Natarajan, K., Meyer, K.B., Miao, Z., McKenzie, A.N.J., et al., 2018 Genome-wide binding studies reveal DNA binding specificity mechanisms and functional interplay amongst Forkhead transcription factors, Chen, X., Ji, Z., Webber, A., and Sharrocks, A.D., 2016 Single-cell RNA-seq identifies a PD-1hi ILC progenitor and defines its development pathway, Yu, Y., Tsang, J.C.H., Wang, C., Clare, S., Wang, J., Chen, X., Brandt, C., Kane, L., Campos, L.S., Lu, L., et al., 2016 Screen for multi-SUMO–binding proteins reveals a multi-SIM–binding mechanism for recruitment of the transcriptional regulator ZMYM2 to chromatin, Aguilar-Martinez, E., Chen, X., Webber, A., Paul Mould, A., Seifert, A., Hay, R.T., and Sharrocks, A.D., 2015 Deregulation of the FOXM1 target gene network and its coregulatory partners in oesophageal adenocarcinoma, Wiseman, E.F., Chen, X., Han, N., Webber, A., Ji, Z., Sharrocks, A.D., and Ang, Y.S., 2015 The forkhead transcription factor FOXM1 controls cell cycle-dependent gene expression through an atypical chromatin binding mechanism, Chen, X., Müller, G.A., Quaas, M., Fischer, M., Han, N., Stutchbury, B., Sharrocks, A.D., and Engeland, K., 2013 From Tissues to Cell Types and Back: Single-Cell Gene Expression Analysis of Tissue Architecture, Chen, X., Teichmann, S.A., and Meyer, K.B., 2018 Single-cell analysis at the threshold, Chen, X., Love, J.C., Navin, N.E., Pachter, L., Stubbington, M.J.T., Svensson, V., Sweedler, J.V., and Teichmann, S.A., 2016 Genetics and immunity in the era of single-cell genomics, Vieira Braga, F.A., Teichmann, S.A., and Chen, X., 2016 ChIPmentation for Low-Input Profiling of In Vivo Protein-DNA Interactions, Kunowska, N., Chen, X., 2019

Areas of Focus

Single-cell epigenetics and transcriptomics sequencing technology development
Genomic data mining and bioinformatics analysis
Study of transcription factors and chromatin complexes in controlling cell fate determination and memory using T cells and stem cells as models

Publications

Genome-wide CRISPR screens in T helper cells reveal pervasive cross-talk between activation and differentiation, Henriksson, J.*, Chen, X.*, Gomes, T., Ullah, U., and Meyer, K.B., 2019
The BAF and PRC2 Complex Subunits Dpf2 and Eed Antagonistically Converge on Tbx3 to Control ESC Differentiation, Zhang, W.*, Chronis, C.*, Chen, X.*, Zhang, H., Spalinskas, R., Pardo, M., Chen, L., Wu, G., Zhu, Z., Yu, Y., et al., 2019
A rapid and robust method for single cell chromatin accessibility profiling, Chen, X., Miragaia, R.J., Natarajan, K.N., and Teichmann, S.A., 2018
Single cell RNA-seq and ATAC-seq analysis of cardiac progenitor cell transition states and lineage settlement, Jia, G.*, Preussner, J.*, Chen, X.*, Guenther, S., Yuan, X., Yekelchyk, M., Kuenne, C., Looso, M., Zhou, Y., Teichmann, S., et al., 2018
Gene expression variability across cells and species shapes innate immunity, Hagai, T., Chen, X., Miragaia, R.J., Rostom, R., Gomes, T., Kunowska, N., Henriksson, J., Park, J.-E., Proserpio, V., Donati, G., et al., 2018
Genome-wide analyses reveal the IRE1a-XBP1 pathway promotes T helper cell differentiation by resolving secretory stress and accelerating proliferation, Pramanik, J., Chen, X., Kar, G., Henriksson, J., Gomes, T., Park, J.-E., Natarajan, K., Meyer, K.B., Miao, Z., McKenzie, A.N.J., et al., 2018
Genome-wide binding studies reveal DNA binding specificity mechanisms and functional interplay amongst Forkhead transcription factors, Chen, X., Ji, Z., Webber, A., and Sharrocks, A.D., 2016
Single-cell RNA-seq identifies a PD-1hi ILC progenitor and defines its development pathway, Yu, Y., Tsang, J.C.H., Wang, C., Clare, S., Wang, J., Chen, X., Brandt, C., Kane, L., Campos, L.S., Lu, L., et al., 2016
Screen for multi-SUMO–binding proteins reveals a multi-SIM–binding mechanism for recruitment of the transcriptional regulator ZMYM2 to chromatin, Aguilar-Martinez, E., Chen, X., Webber, A., Paul Mould, A., Seifert, A., Hay, R.T., and Sharrocks, A.D., 2015
Deregulation of the FOXM1 target gene network and its coregulatory partners in oesophageal adenocarcinoma, Wiseman, E.F., Chen, X., Han, N., Webber, A., Ji, Z., Sharrocks, A.D., and Ang, Y.S., 2015
The forkhead transcription factor FOXM1 controls cell cycle-dependent gene expression through an atypical chromatin binding mechanism, Chen, X., Müller, G.A., Quaas, M., Fischer, M., Han, N., Stutchbury, B., Sharrocks, A.D., and Engeland, K., 2013
From Tissues to Cell Types and Back: Single-Cell Gene Expression Analysis of Tissue Architecture, Chen, X., Teichmann, S.A., and Meyer, K.B., 2018
Single-cell analysis at the threshold, Chen, X., Love, J.C., Navin, N.E., Pachter, L., Stubbington, M.J.T., Svensson, V., Sweedler, J.V., and Teichmann, S.A., 2016
Genetics and immunity in the era of single-cell genomics, Vieira Braga, F.A.*, Teichmann, S.A., and Chen, X.*, 2016
ChIPmentation for Low-Input Profiling of In Vivo Protein-DNA Interactions, Kunowska, N.*, Chen, X*., 2019

Single-Cell Epigenetics Transcriptomics Sequencing Genomics Bioinformatics Data Mining T Cells Stem Cells Transcription Factors

Qi Liu - Tongji University

Chenfei Wang - Tongji University

Xiaoou Zhang - Tongji University

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