2003/09 – 2008/07, PhD in Biochemistry and Molecular Biology, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences (Supervisor: Jianping Ding)
Received National Science Foundation for Distinguished Young Scholars in 2023
2019/02 – Present, Professor, Department of Biology, Southern University of Science and Technology
2017/10 – 2019/01, Young Research Leader, Center for Excellence in Molecular Plant Sciences, Chinese Academy of Sciences
2014/09 – 2019/01, Researcher, Shanghai Center for Plant Stress Biology, Shanghai Institutes for Biological Sciences
2009/10 – 2014/08, Postdoctoral Fellow, Memorial Sloan Kettering Cancer Center (Research Supervisor: Dinshaw J. Patel)
2008/07 – 2009/09, Assistant Researcher, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences
2023: National Science Foundation for Distinguished Young Scholars
2022: Outstanding Young Scientist Award, Chinese Society of Plant Physiology and Molecular Biology
2022: President's Distinguished Research Award, Southern University of Science and Technology
2022: Outstanding Graduate Advisor Award, Southern University of Science and Technology
2020: Wei Zhiming Youth Innovation Award, Chinese Society of Plant Physiology and Molecular Biology
2020: Leading Goose Silver Award, University of Chinese Academy of Sciences
2019: Excellent Mentor Award, Chinese Academy of Sciences
2018: Excellent Mentor Award, Chinese Academy of Sciences
2017: National Science Foundation for Excellent Young Scientists
2016: Chief Scientist, National Key R&D Program of the Ministry of Science and Technology (Youth)
Research
Plant gene regulation Epigenetic regulation in plants
Structure and mechanism of the plant RNA polymerase V, Xie G, Du X, Hu H, Li S, Cao X, Jacobsen S.E, and Du J, 2023
Molecular basis of the plant ROS1-mediated active DNA demethylation, Du X, Yang Z, Xie G, Wang C, Zhang L, Yan K, Yang M, Li S, Zhu JK, Du J, 2023
Molecular basis of locus-specific H3K9 methylation catalyzed by SUVH6 in plants, Zhang J, Yuan J, Lin J, Chen L, You LY, Chen S, Peng L, Wang CH, Du J, Duan CG, 2023
Structure and Mechanism of Plant DNA Methyltransferases, Leichter SM, Du J, Zhong X, 2022
The H3K9me2-binding protein AGDP3 limits DNA methylation and transcriptional gene silencing in Arabidopsis, Zhou X, Wei M, Nie W, Xi Y, Peng L, Zheng Q, Tang K, Satheesh V, Wang Y, Luo J, Du X, Liu R, Yang Z, La H, Zhong Y, Yang Y, Zhu JK, Du J, Lei M, 2022
Cofactor-assisted dicing: insights from structural snapshots, Du J, Patel DJ, 2022
Making a 6mA demethylase, Li S, Du J, 2022
A SYBR Gold-based Label-free in vitro Dicing Assay, Wang Q, Xue Y, Zhang L, Zhong Z, Feng S, Wang C, Xiao L, Yang Z, Harris JC, Wu Z, Zhai J, Yang M, Li S, Jacobsen SE, Du J, 2022
Structure and mechanism of histone methylation dynamics in Arabidopsis, Hu H, Du J, 2022
Structure of plant RNA-DEPENDENT RNA POLYMERASE 2, an enzyme involved in small interfering RNA production, Du X, Yang Z, Ariza AJF, Wang Q, Xie G, Li S, Du J, 2022
Molecular basis of CONSTANS oligomerization in FLOWERING LOCUS T activation, Zeng X, Lv X, Liu R, He H, Liang S, Chen L, Zhang F, Chen L, He Y, Du J, 2022
Mechanism of siRNA production by a plant Dicer-RNA complex in dicing-competent conformation, Wang Q, Xue Y, Zhang L, Zhong Z, Feng S, Wang C, Xiao L, Yang Z, Harris CJ, Wu Z, Zhai J, Yang M, Li S, Jacobsen SE, Du J, 2021
TEM1 combinatorially binds to FLOWERING LOCUS T and recruits a Polycomb factor to repress the floral transition in Arabidopsis, Hu H, Tian S, Xie G, Liu R, Wang N, Li S, He Y, Du J, 2021
Recognition of H3K9me1 by maize RNA-directed DNA methylation factor SHH2, Wang Y, Zhou X, Luo J, Lv S, Liu R, Du X, Jia B, Yuan F, Zhang H, Du J, 2021
A histone H3K4me1-specific binding protein is required for siRNA accumulation and DNA methylation at a subset of loci targeted by RNA-directed DNA methylation, Niu Q, Song Z, Tang K, Chen L, Wang L, Ban T, Guo Z, Kim C, Zhang H, Duan CG, Zhang H, Zhu JK, Du J, Lang Z, 2021
Structural insights into the multivalent binding of the Arabidopsis FLOWERING LOCUS T promoter by the CO-NF-Y master transcription factor complex, Lv X, Zeng X, Hu H, Chen L, Zhang F, Liu R, Liu Y, Zhou X, Wang C, Wu Z, Kim C, He Y, Du J, 2021
Coupling of H3K27me3 recognition with transcriptional repression through the BAH-PHD-CPL2 complex in Arabidopsis, Zhang YZ, Yuan J, Zhang L, Chen C, Wang Y, Zhang G, Peng L, Xie SS, Jiang J, Zhu JK, Du J, Duan CG, 2020
Dual Recognition of H3K4me3 and DNA by the ISWI Component ARID5 Regulates the Floral Transition in Arabidopsis, Tan LM, Liu R, Gu BW, Zhang CJ, Luo J, Guo J, Wang Y, Chen L, Du X, Li S, Shao CR, Su YN, Cai XW, Lin RN, Li L, Chen S, Du J, He XJ, 2020
Embryonic resetting of the parental vernalized state by two B3 domain transcription factors in Arabidopsis, Tao Z, Hu H, Luo X, Jia B, Du J, He Y, 2019
The Arabidopsis H3K27me3 demethylase JUMONJI 13 is a temperature and photoperiod dependent flowering repressor, Zheng S, Hu H, Ren H, Yang Z, Qiu Q, Qi W, Liu X, Chen X, Cui X, Li S, Zhou B, Sun D, Cao X, Du J, 2019
A DNA methylation reader complex that enhances gene transcription, Harris CJ, Scheibe M, Wongpalee SP, Liu W, Cornett EM, Vaughan RM, Li X, Chen W, Xue Y, Zhong Z, Yen L, Barshop WD, Rayatpisheh S, Gallego-Bartolome J, Groth M, Wang Z, Wohlschlegel JA, Du J, Rothbart SB, Butter F, Jacobsen SE, 2018
Arabidopsis AGDP1 links H3K9me2 to DNA methylation in heterochromatin, Zhang C, Du X, Tang K, Yang Z, Pan L, Zhu P, Luo J, Jiang Y, Zhang H, Wan H, Wang X, Wu F, Tao WA, He XJ, Zhang H, Bressan RA, Du J, Zhu JK, 2018
Area of Focus
Epigenetics | Embryonic Development | Cell Fate | Cancer | Metastasis | Drug Resistance | Gene Expression | Dna Methylation | Histone Modification | Chromatin Structure