Upload Avatar (500 x 500)
Mao-Fu Liao
Life Science
Southern University of Science and Technology
Guangdong
Language: English, Chinese
Cryo-Em
Methodology
Scientific Research
Biomolecules
Mechanisms
Structural Biology
Medical Innovation
Biological Structures
Molecular Biology
Medical Methods
Areas of Focus
- Development of cryo-EM methodologies for new scientific research areas
- Elucidation of the fine mechanisms of operation of biomolecules
- Using structural and mechanistic information of biology to innovate medical methods
Work Experience
- 2014-2022 - Harvard Medical School: Assistant Professor, Associate Professor
- 2022-present - Southern University of Science and Technology: Chair Professor
Academic Background & Achievements
- 1999 - BSc in Biological Sciences and Technology: Tsinghua University
- 2006 - PhD: Albert Einstein College of Medicine
- Postdoctoral work at University of California, San Francisco
Publications
- Sub-3-Å cryo-EM structure of RNA enabled by engineered homomeric self-assembly, Liu D, Thélot FA, Piccirilli JA, Liao M, Yin P, 2022
- Distinct allosteric mechanisms of first-generation MsbA inhibitors, Thélot FA, Zhang W, Song K, Xu C, Huang J, Liao M, 2021
- Mechanism of LolCDE as a molecular extruder of bacterial triacylated lipoproteins, Sharma S, Zhou R, Wan L, Feng S, Song K, Xu C, Li Y, Liao M, 2021
- ABCG2 transports anticancer drugs via a closed-to-open switch, Orlando BJ, Liao M, 2020
- Structure and catalytic mechanism of a human triacylglycerol-synthesis enzyme, Sui X, Wang K, Gluchowski NL, Elliott SD, Liao M, Walther TC, Farese RV Jr, 2020
- Structural basis of lipopolysaccharide extraction by the LptB2FGC complex, Li Y, Orlando BJ, Liao M, 2019
- High-resolution cryo-EM analysis of the yeast ATP synthase in a lipid membrane, Srivastava AP, Luo M, Zhou W, Symersky J, Bai D, Chambers MG, Faraldo-Gómez JD, Liao M, Mueller DM, 2018
- Structural basis of MsbA-mediated lipopolysaccharide transport, Mi W, Li Y, Yoon SH, Ernst RK, Walz T, Liao M, 2017
- Cryo-EM structure of the protein-conducting ERAD channel Hrd1 in complex with Hrd3, Schoebel S, Mi W, Stein A, Ovchinnikov S, Pavlovicz R, DiMaio F, Baker D, Chambers MG, Su H, Li D, Rapoport TA, Liao M, 2017
- Structure of the TRPV1 ion channel determined by electron cryo-microscopy, Liao M, Cao E, Julius D, Cheng Y, 2013
