Professor | Mao-Fu Liao | Asia Growth Partners

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Name	Mao-Fu Liao
Contact Information	liaomf@sustech.edu.cn
Language ability	English, Chinese
Province	Guangdong

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Name

Mao-Fu Liao

Contact Information

liaomf@sustech.edu.cn

Language ability

English, Chinese

Province

Guangdong

University/Lab Affiliation and Title	Southern University of Science and Technology
Faculty	Life Sciences
Academic Background & Achievements	1999 - BSc in Biological Sciences and Technology: Tsinghua University 2006 - PhD: Albert Einstein College of Medicine Postdoctoral work at University of California, San Francisco
Work Experience	2014-2022 - Harvard Medical School: Assistant Professor, Associate Professor 2022-present - Southern University of Science and Technology: Chair Professor

University/Lab Affiliation and Title

Southern University of Science and Technology

Faculty

Life Sciences

Academic Background & Achievements

1999 - BSc in Biological Sciences and Technology: Tsinghua University
2006 - PhD: Albert Einstein College of Medicine
Postdoctoral work at University of California, San Francisco

Work Experience

2014-2022 - Harvard Medical School: Assistant Professor, Associate Professor
2022-present - Southern University of Science and Technology: Chair Professor

Areas of Focus	Development of cryo-EM methodologies for new scientific research areas Elucidation of the fine mechanisms of operation of biomolecules Using structural and mechanistic information of biology to innovate medical methods
Publications	Sub-3-Å cryo-EM structure of RNA enabled by engineered homomeric self-assembly, Liu D, Thélot FA, Piccirilli JA, Liao M, Yin P, 2022 Distinct allosteric mechanisms of first-generation MsbA inhibitors, Thélot FA, Zhang W, Song K, Xu C, Huang J, Liao M, 2021 Mechanism of LolCDE as a molecular extruder of bacterial triacylated lipoproteins, Sharma S, Zhou R, Wan L, Feng S, Song K, Xu C, Li Y, Liao M, 2021 ABCG2 transports anticancer drugs via a closed-to-open switch, Orlando BJ, Liao M, 2020 Structure and catalytic mechanism of a human triacylglycerol-synthesis enzyme, Sui X, Wang K, Gluchowski NL, Elliott SD, Liao M, Walther TC, Farese RV Jr, 2020 Structural basis of lipopolysaccharide extraction by the LptB2FGC complex, Li Y, Orlando BJ, Liao M, 2019 High-resolution cryo-EM analysis of the yeast ATP synthase in a lipid membrane, Srivastava AP, Luo M, Zhou W, Symersky J, Bai D, Chambers MG, Faraldo-Gómez JD, Liao M, Mueller DM, 2018 Structural basis of MsbA-mediated lipopolysaccharide transport, Mi W, Li Y, Yoon SH, Ernst RK, Walz T, Liao M, 2017 Cryo-EM structure of the protein-conducting ERAD channel Hrd1 in complex with Hrd3, Schoebel S, Mi W, Stein A, Ovchinnikov S, Pavlovicz R, DiMaio F, Baker D, Chambers MG, Su H, Li D, Rapoport TA, Liao M, 2017 Structure of the TRPV1 ion channel determined by electron cryo-microscopy, Liao M, Cao E, Julius D, Cheng Y, 2013

Areas of Focus

Development of cryo-EM methodologies for new scientific research areas
Elucidation of the fine mechanisms of operation of biomolecules
Using structural and mechanistic information of biology to innovate medical methods

Publications

Sub-3-Å cryo-EM structure of RNA enabled by engineered homomeric self-assembly, Liu D, Thélot FA, Piccirilli JA, Liao M, Yin P, 2022
Distinct allosteric mechanisms of first-generation MsbA inhibitors, Thélot FA, Zhang W, Song K, Xu C, Huang J, Liao M, 2021
Mechanism of LolCDE as a molecular extruder of bacterial triacylated lipoproteins, Sharma S, Zhou R, Wan L, Feng S, Song K, Xu C, Li Y, Liao M, 2021
ABCG2 transports anticancer drugs via a closed-to-open switch, Orlando BJ, Liao M, 2020
Structure and catalytic mechanism of a human triacylglycerol-synthesis enzyme, Sui X, Wang K, Gluchowski NL, Elliott SD, Liao M, Walther TC, Farese RV Jr, 2020
Structural basis of lipopolysaccharide extraction by the LptB2FGC complex, Li Y, Orlando BJ, Liao M, 2019
High-resolution cryo-EM analysis of the yeast ATP synthase in a lipid membrane, Srivastava AP, Luo M, Zhou W, Symersky J, Bai D, Chambers MG, Faraldo-Gómez JD, Liao M, Mueller DM, 2018
Structural basis of MsbA-mediated lipopolysaccharide transport, Mi W, Li Y, Yoon SH, Ernst RK, Walz T, Liao M, 2017
Cryo-EM structure of the protein-conducting ERAD channel Hrd1 in complex with Hrd3, Schoebel S, Mi W, Stein A, Ovchinnikov S, Pavlovicz R, DiMaio F, Baker D, Chambers MG, Su H, Li D, Rapoport TA, Liao M, 2017
Structure of the TRPV1 ion channel determined by electron cryo-microscopy, Liao M, Cao E, Julius D, Cheng Y, 2013

Cryo-Em Methodology Scientific Research Biomolecules Mechanisms Structural Biology Medical Innovation Biological Structures Molecular Biology Medical Methods

Xueming Li - Tsinghua University

Xiao-Lei Wang - Shanghai Jiao Tong University

Yong Wang - Zhejiang University

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