Professor | Huaqing Chen | Asia Growth Partners

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Name	Huaqing Chen
Contact Information	hqchen@bio.ecnu.edu.cn
Language ability	English, Chinese
Province	Shanghai

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Name

Huaqing Chen

Contact Information

hqchen@bio.ecnu.edu.cn

Language ability

English, Chinese

Province

Shanghai

University/Lab Affiliation and Title	East China Normal University
Faculty	Life Sciences
Academic Background & Achievements	1994/7 - 1997/11, PhD in Immunology, King's College London 1986/9 - 1989/8, Master in Immunology, Shanghai Second Medical University 1982/9 - 1986/8, Bachelor in Microbiology, Fudan University
Work Experience	2007 - Present, East China Normal University, Institute of Biomedical Sciences, Senior Engineer 1998 - 2006, Shanghai Industrial Kehua Biotechnology Co., Ltd., R&D Department Director, Senior Engineer 1994 - 1997, GlaxoWellcome UK Research Centre, Cell Biology, Visiting Scholar 1993 - 1994, Wellcome Research Laboratories UK, Visiting Scholar 1989 - 1992, Shanghai Institute of Biological Products, Immunology Research Laboratory, Assistant Researcher

University/Lab Affiliation and Title

East China Normal University

Faculty

Life Sciences

Academic Background & Achievements

1994/7 - 1997/11, PhD in Immunology, King's College London
1986/9 - 1989/8, Master in Immunology, Shanghai Second Medical University
1982/9 - 1986/8, Bachelor in Microbiology, Fudan University

Work Experience

2007 - Present, East China Normal University, Institute of Biomedical Sciences, Senior Engineer
1998 - 2006, Shanghai Industrial Kehua Biotechnology Co., Ltd., R&D Department Director, Senior Engineer
1994 - 1997, GlaxoWellcome UK Research Centre, Cell Biology, Visiting Scholar
1993 - 1994, Wellcome Research Laboratories UK, Visiting Scholar
1989 - 1992, Shanghai Institute of Biological Products, Immunology Research Laboratory, Assistant Researcher

Areas of Focus	Immunology Inflammation and Metabolism Disease Models
Publications	Therapeutic potentiation of the immune system by costimulatory Schiff base-forming drugs, Huaqing Chen, 1995 Schiff base forming drugs: mechanisms of immune potentiation and therapeutic potential, Huaqing Chen, 1996 Convergence of Schiff base costimulatory signalling and T-cell receptor signalling at the level of MAP kinase ERK2, Huaqing Chen, 1997 Potentiation of the immune system by Schiff base-forming drugs: Mechanism of action and therapeutic potential, Huaqing Chen, 1997 席夫碱和免疫增强剂：作用机理及应用潜力, Huaqing Chen, 1998 离子转运抑制剂对席夫碱增强免疫效应的影响, Huaqing Chen, 2000 抗HBeAg不同位点的单克隆抗体杂交瘤细胞株的制备及其应用, Huaqing Chen, 2006 G蛋白偶联受体及其信号传导在免疫与炎症中的作用, Huaqing Chen, 2009 Amelioration of Experimental Autoimmune Encephalomyelitis by Plumbagin through Down-Regulation of JAK-STAT and NF-κB Signaling Pathways, Huaqing Chen, 2011 丁酸钠及其G蛋白偶联受体对T淋巴细胞的调节作用, Huaqing Chen, 2012 A Novel TGR5 Activator WB403 Promotes GLP-1 Secretion and Preserves Pancreatic β-cells in Type 2 Diabetic Mice, Huaqing Chen, 2015 PubAngioGen: a database and knowledge for angiogenesis and related diseases, Huaqing Chen, 2015 Lage genomic fragment deletion and functional cassette knock in via Cas9 protein mediated genome editing in one cell embryos, Huaqing Chen, 2015 LGR4 is a receptor for RANKL and negatively regulates osteoclast differentiation and bone resorption, Huaqing Chen, 2016 Effects of Melanocortin 3 and 4 receptor deficiency on energy homostasis in rats, Huaqing Chen, 2016 A Betulinic acid derivative SH479 inhibits collagen-induced arthritis by modulating T cell differentiation and cytokine balance, Huaqing Chen, 2017 SH479, a betulinic acid derivative, ameliorates experimental autoimmune encephalomyelitis by regulating the Th17/Treg balance, Huaqing Chen, 2017 Elevation of GPRC5A expression in colorectal cancer promotes tumor progression through VNN-1 induced oxidative stress, Huaqing Chen, 2017 Hyperlipidemia induces typical atherosclerosis development in Ldlr and Apoe deficient rats, Huaqing Chen, 2018 Kisspeptin receptor GPR54 promotes adipocyte differentiation and fat accumulation in mice, Huaqing Chen, 2018 GPR54 Deficiency Reduces the Treg Population and Aggravates Experimental Autoimmune Encephalomyelitis in Mice, Huaqing Chen, 2018 Novel Rat Models for Atherosclerosis, Huaqing Chen, 2018 The G2A receptor deficiency aggravates atherosclerosis in rats by regulating macrophages and lipid metabolism, Huaqing Chen, 2021

Areas of Focus

Immunology
Inflammation and Metabolism
Disease Models

Publications

Therapeutic potentiation of the immune system by costimulatory Schiff base-forming drugs, Huaqing Chen, 1995
Schiff base forming drugs: mechanisms of immune potentiation and therapeutic potential, Huaqing Chen, 1996
Convergence of Schiff base costimulatory signalling and T-cell receptor signalling at the level of MAP kinase ERK2, Huaqing Chen, 1997
Potentiation of the immune system by Schiff base-forming drugs: Mechanism of action and therapeutic potential, Huaqing Chen, 1997
席夫碱和免疫增强剂：作用机理及应用潜力, Huaqing Chen, 1998
离子转运抑制剂对席夫碱增强免疫效应的影响, Huaqing Chen, 2000
抗HBeAg不同位点的单克隆抗体杂交瘤细胞株的制备及其应用, Huaqing Chen, 2006
G蛋白偶联受体及其信号传导在免疫与炎症中的作用, Huaqing Chen, 2009
Amelioration of Experimental Autoimmune Encephalomyelitis by Plumbagin through Down-Regulation of JAK-STAT and NF-κB Signaling Pathways, Huaqing Chen, 2011
丁酸钠及其G蛋白偶联受体对T淋巴细胞的调节作用, Huaqing Chen, 2012
A Novel TGR5 Activator WB403 Promotes GLP-1 Secretion and Preserves Pancreatic β-cells in Type 2 Diabetic Mice, Huaqing Chen, 2015
PubAngioGen: a database and knowledge for angiogenesis and related diseases, Huaqing Chen, 2015
Lage genomic fragment deletion and functional cassette knock in via Cas9 protein mediated genome editing in one cell embryos, Huaqing Chen, 2015
LGR4 is a receptor for RANKL and negatively regulates osteoclast differentiation and bone resorption, Huaqing Chen, 2016
Effects of Melanocortin 3 and 4 receptor deficiency on energy homostasis in rats, Huaqing Chen, 2016
A Betulinic acid derivative SH479 inhibits collagen-induced arthritis by modulating T cell differentiation and cytokine balance, Huaqing Chen, 2017
SH479, a betulinic acid derivative, ameliorates experimental autoimmune encephalomyelitis by regulating the Th17/Treg balance, Huaqing Chen, 2017
Elevation of GPRC5A expression in colorectal cancer promotes tumor progression through VNN-1 induced oxidative stress, Huaqing Chen, 2017
Hyperlipidemia induces typical atherosclerosis development in Ldlr and Apoe deficient rats, Huaqing Chen, 2018
Kisspeptin receptor GPR54 promotes adipocyte differentiation and fat accumulation in mice, Huaqing Chen, 2018
GPR54 Deficiency Reduces the Treg Population and Aggravates Experimental Autoimmune Encephalomyelitis in Mice, Huaqing Chen, 2018
Novel Rat Models for Atherosclerosis, Huaqing Chen, 2018
The G2A receptor deficiency aggravates atherosclerosis in rats by regulating macrophages and lipid metabolism, Huaqing Chen, 2021

Immunology Inflammation Metabolism Disease Models Cell Signaling Therapeutic Targets Immune System Pathogenesis Molecular Biology Biochemistry

Yanfang Wang - Tongji University

Shaojun Dai - Shanghai Normal University

Shui Wang - Shanghai Normal University

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