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Jian Luo
Life Science
East China Normal University
Shanghai
Language: Chinese, English
Stem Cells
Clinical Therapy
G Protein
Cell Signaling
Bone Tumors
Osteoporosis
Arthritis
Intervertebral Disc
Drug Development
Degeneration
Areas of Focus
- Stem cell clinical therapy development
- G protein-coupled receptor cell signaling pathways
- Drug development for bone tumors, osteoporosis, arthritis, and intervertebral disc degeneration
Work Experience
- 2010 - Present: Reviewer for international journals such as Cancer Res, Mol Oncol, Curr Mol Med, Eur J Nutr, BMC Cancer, J Agric Food Chem
- 2009 - Present: Member of the Chinese Society for Cell Biology and Shanghai Society for Cell Biology
- 2016 - Present: Youth Committee Member of the Chinese Society of Physiology, Matrix Biology Branch
- 2017 - Present: Member of the Chinese Biochemical Society and Shanghai Biochemical and Molecular Biology Society
- 2017 - Present: Director of the Shanghai Society for Cell Biology
- 2017 - Present: Committee Member of the Chinese Society for Cell Biology, Tumor Cell Biology Branch
- 2017 - Present: Executive Member of the Chinese Geriatrics Society, Osteoporosis Branch, Basic Medical Group
- 2018 - Present: Founding Director of the Chinese Osteoporosis Prevention Alliance
- 2018 - Present: Executive Member of the Shanghai Integrated Traditional and Western Medicine Society, Osteoporosis Committee
- 2018 - Present: Committee Member of the Shanghai Medical Association, Integrative Medicine Branch
- 2018 - Present: Deputy Group Leader of the Chinese Medical Association Orthopedics Youth Committee, Basic Studies Group
- 2018 - Present: Secretary-General of the Chinese Geriatrics Society and Geriatric Medicine Society, Orthopedics Expert Committee
- 2019 - Present: Executive Member of the International Orthopedics and Traumatology Society (SICOT), China Department, Basic Research Committee
- 2019 - Present: Committee Member of the Chinese Society for Cell Biology, Signal Transduction Branch
- 2019 - Present: Committee Member of the Chinese Geriatrics Society and Geriatric Medicine Society, Geriatric Orthopedics Branch, Basic Studies Group
- 2019 - Present: Deputy Director of the Chinese Anti-Cancer Association, Tumor Microenvironment Professional Committee, Youth Committee
Academic Background & Achievements
- PhD: Not mentioned
- National Outstanding Youth, Ministry of Education High-level Young Talent
Publications
- RSPO2/RANKL-LGR4 signaling regulates osteoclastic pre-metastatic niche formation and bone metastasis, Luo J et al., 2022
- PGE2 Activates EP4 in Subchondral Bone Osteoclasts to Regulate Osteoarthritis, Luo J et al., 2022
- A Novel Prostaglandin E Receptor 4 (EP4) Small Molecule Antagonist Induces Articular Cartilage Regeneration, Luo J et al., 2022
- Regulation of Body Length and Bone Mass by Gpr126/Adgr6, Luo J et al., 2020
- LGR4 is a receptor for RANKL and negatively regulates osteoclast differentiation and bone resorption, Luo J et al., 2016
- GPR116, an Adhesion G-Protein Coupled Receptor, Promotes Breast Cancer Metastasis via the Gαq-p63RhoGEF-Rho GTPase Pathway, Luo J et al., 2013
- Inhibition of Breast Cancer Metastases by a Novel Inhibitor of TGFβ Receptor 1, Luo J et al., 2013
- CADPE suppresses RANKL-induced osteoclastogenesis and prevents ovariectomy-induced bone loss through inhibition of MAPK/AP-1 and Ca(2+)-NFAT signaling pathways, Luo J et al., 2012
Awards
- 2017: Chinese Orthopedic Association (COA) Basic Young Research Award, First Prize
- 2017: Shanghai Science and Technology Progress First Prize
