Professor | Jian Luo | Asia Growth Partners

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Name	Jian Luo
Contact Information	jluo@bio.ecnu.edu.cn
Language ability	Chinese, English
Province	Shanghai

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Name

Jian Luo

Contact Information

jluo@bio.ecnu.edu.cn

Language ability

Chinese, English

Province

Shanghai

University/Lab Affiliation and Title	East China Normal University
Faculty	Life Sciences
Academic Background & Achievements	PhD: Not mentioned National Outstanding Youth, Ministry of Education High-level Young Talent
Work Experience	2010 - Present: Reviewer for international journals such as Cancer Res, Mol Oncol, Curr Mol Med, Eur J Nutr, BMC Cancer, J Agric Food Chem 2009 - Present: Member of the Chinese Society for Cell Biology and Shanghai Society for Cell Biology 2016 - Present: Youth Committee Member of the Chinese Society of Physiology, Matrix Biology Branch 2017 - Present: Member of the Chinese Biochemical Society and Shanghai Biochemical and Molecular Biology Society 2017 - Present: Director of the Shanghai Society for Cell Biology 2017 - Present: Committee Member of the Chinese Society for Cell Biology, Tumor Cell Biology Branch 2017 - Present: Executive Member of the Chinese Geriatrics Society, Osteoporosis Branch, Basic Medical Group 2018 - Present: Founding Director of the Chinese Osteoporosis Prevention Alliance 2018 - Present: Executive Member of the Shanghai Integrated Traditional and Western Medicine Society, Osteoporosis Committee 2018 - Present: Committee Member of the Shanghai Medical Association, Integrative Medicine Branch 2018 - Present: Deputy Group Leader of the Chinese Medical Association Orthopedics Youth Committee, Basic Studies Group 2018 - Present: Secretary-General of the Chinese Geriatrics Society and Geriatric Medicine Society, Orthopedics Expert Committee 2019 - Present: Executive Member of the International Orthopedics and Traumatology Society (SICOT), China Department, Basic Research Committee 2019 - Present: Committee Member of the Chinese Society for Cell Biology, Signal Transduction Branch 2019 - Present: Committee Member of the Chinese Geriatrics Society and Geriatric Medicine Society, Geriatric Orthopedics Branch, Basic Studies Group 2019 - Present: Deputy Director of the Chinese Anti-Cancer Association, Tumor Microenvironment Professional Committee, Youth Committee
Awards	2017: Chinese Orthopedic Association (COA) Basic Young Research Award, First Prize 2017: Shanghai Science and Technology Progress First Prize

University/Lab Affiliation and Title

East China Normal University

Faculty

Life Sciences

Academic Background & Achievements

PhD: Not mentioned
National Outstanding Youth, Ministry of Education High-level Young Talent

Work Experience

2010 - Present: Reviewer for international journals such as Cancer Res, Mol Oncol, Curr Mol Med, Eur J Nutr, BMC Cancer, J Agric Food Chem
2009 - Present: Member of the Chinese Society for Cell Biology and Shanghai Society for Cell Biology
2016 - Present: Youth Committee Member of the Chinese Society of Physiology, Matrix Biology Branch
2017 - Present: Member of the Chinese Biochemical Society and Shanghai Biochemical and Molecular Biology Society
2017 - Present: Director of the Shanghai Society for Cell Biology
2017 - Present: Committee Member of the Chinese Society for Cell Biology, Tumor Cell Biology Branch
2017 - Present: Executive Member of the Chinese Geriatrics Society, Osteoporosis Branch, Basic Medical Group
2018 - Present: Founding Director of the Chinese Osteoporosis Prevention Alliance
2018 - Present: Executive Member of the Shanghai Integrated Traditional and Western Medicine Society, Osteoporosis Committee
2018 - Present: Committee Member of the Shanghai Medical Association, Integrative Medicine Branch
2018 - Present: Deputy Group Leader of the Chinese Medical Association Orthopedics Youth Committee, Basic Studies Group
2018 - Present: Secretary-General of the Chinese Geriatrics Society and Geriatric Medicine Society, Orthopedics Expert Committee
2019 - Present: Executive Member of the International Orthopedics and Traumatology Society (SICOT), China Department, Basic Research Committee
2019 - Present: Committee Member of the Chinese Society for Cell Biology, Signal Transduction Branch
2019 - Present: Committee Member of the Chinese Geriatrics Society and Geriatric Medicine Society, Geriatric Orthopedics Branch, Basic Studies Group
2019 - Present: Deputy Director of the Chinese Anti-Cancer Association, Tumor Microenvironment Professional Committee, Youth Committee

Awards

2017: Chinese Orthopedic Association (COA) Basic Young Research Award, First Prize
2017: Shanghai Science and Technology Progress First Prize

Areas of Focus	Stem cell clinical therapy development G protein-coupled receptor cell signaling pathways Drug development for bone tumors, osteoporosis, arthritis, and intervertebral disc degeneration
Publications	RSPO2/RANKL-LGR4 signaling regulates osteoclastic pre-metastatic niche formation and bone metastasis, Luo J et al., 2022 PGE2 Activates EP4 in Subchondral Bone Osteoclasts to Regulate Osteoarthritis, Luo J et al., 2022 A Novel Prostaglandin E Receptor 4 (EP4) Small Molecule Antagonist Induces Articular Cartilage Regeneration, Luo J et al., 2022 Regulation of Body Length and Bone Mass by Gpr126/Adgr6, Luo J et al., 2020 LGR4 is a receptor for RANKL and negatively regulates osteoclast differentiation and bone resorption, Luo J et al., 2016 GPR116, an Adhesion G-Protein Coupled Receptor, Promotes Breast Cancer Metastasis via the Gαq-p63RhoGEF-Rho GTPase Pathway, Luo J et al., 2013 Inhibition of Breast Cancer Metastases by a Novel Inhibitor of TGFβ Receptor 1, Luo J et al., 2013 CADPE suppresses RANKL-induced osteoclastogenesis and prevents ovariectomy-induced bone loss through inhibition of MAPK/AP-1 and Ca(2+)-NFAT signaling pathways, Luo J et al., 2012

Areas of Focus

Stem cell clinical therapy development
G protein-coupled receptor cell signaling pathways
Drug development for bone tumors, osteoporosis, arthritis, and intervertebral disc degeneration

Publications

RSPO2/RANKL-LGR4 signaling regulates osteoclastic pre-metastatic niche formation and bone metastasis, Luo J et al., 2022
PGE2 Activates EP4 in Subchondral Bone Osteoclasts to Regulate Osteoarthritis, Luo J et al., 2022
A Novel Prostaglandin E Receptor 4 (EP4) Small Molecule Antagonist Induces Articular Cartilage Regeneration, Luo J et al., 2022
Regulation of Body Length and Bone Mass by Gpr126/Adgr6, Luo J et al., 2020
LGR4 is a receptor for RANKL and negatively regulates osteoclast differentiation and bone resorption, Luo J et al., 2016
GPR116, an Adhesion G-Protein Coupled Receptor, Promotes Breast Cancer Metastasis via the Gαq-p63RhoGEF-Rho GTPase Pathway, Luo J et al., 2013
Inhibition of Breast Cancer Metastases by a Novel Inhibitor of TGFβ Receptor 1, Luo J et al., 2013
CADPE suppresses RANKL-induced osteoclastogenesis and prevents ovariectomy-induced bone loss through inhibition of MAPK/AP-1 and Ca(2+)-NFAT signaling pathways, Luo J et al., 2012

Stem Cells Clinical Therapy G Protein Cell Signaling Bone Tumors Osteoporosis Arthritis Intervertebral Disc Drug Development Degeneration

Xi Zhi Guo - Shanghai Jiao Tong University

Jian Luo - East China Normal University

Weiqiang Lu - East China Normal University

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