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Yan Feng
Life Science
Shanghai Jiao Tong University
Shanghai
Language: English, Chinese
Enzyme
Molecular
Design
Evolution
Microbial
Gene
Health
Medicine
Synthesis
Biotechnology
Areas of Focus
- Molecular Enzymology
- Synthetic Biology
- Microbial Drug Synthesis
Work Experience
- 1989-2008 - Jilin University, Lecturer, Associate Professor, Professor, Director of the Key Laboratory of Molecular Enzymology and Engineering
- 2009-present - Distinguished Professor at Shanghai Jiao Tong University, Doctoral Supervisor
Academic Background & Achievements
- 1986 - Bachelor's Degree in Molecular Biology from Jilin University
- 1994 - PhD in Medicine from Norman Bethune College of Medicine
- Postdoctoral Researcher at National Institute of Bioscience and Human-Technology, Japan (1994-1996, 1998-2000)
- Chief Scientist of the 973 Program, received support and awards such as the Ministry of Education's New Century Talent, the State Council Special Allowance, and Shanghai Leading Talent
Publications
- A Validamycin Shunt Pathway for Valienamine Synthesis in Engineered Streptomyces hygroscopicus 5008, Cui L., Wei X., Wang X., Bai L., Lin S., Feng Y*., 2020
- Structure-guided reshaping of the acyl binding pocket of 'TesAthioesterase enhances octanoic acid production in E. coli, Deng X., Chen L., Hei M., Tian G., Feng Y*., Yang G*., 2020
- Argonaute integrated single-tube PCR system enables supersensitive detection of rare mutations, Liu Q., Guo X., Xun G., Li Z., Chong Y., Yang L., Wang H., Zhang F., Luo S., Cui L., Zhao P., Ye X., Xu H., Lu H., Li X., Deng Z., Li K., Feng Y.*, 2021
- Catalytic properties and biological function of a PIWI-RE nuclease from Pseudomonas stutzeri, Huang F, Xu X.Y., Dong H., Li N., Zhong B.Z., Lu H., Liu Q., Feng Y.*, 2022
- Loosely-packed dynamical structures with partially-melted surface being the key for thermophilic argonaute proteins achieving high DNA-cleavage activity, Zheng L., Lu H., Zan B., Li S., Liu H., Liu Z., Huang.J, Liu Y, Jiang F., Liu Q.*, Feng Y., Hong L.*, 2022
- Molecular Evolution of an Aminotransferase Based on Substrate–Enzyme Binding Energy Analysis for Efficient Valienamine Synthesis, Cui L*., Cui, A., Li Q., Yang L., Liu H., Shao W., Feng Y.*, 2022
- Discovery and Engineering of the l-Threonine Aldolase from Neptunomonas marine for the Efficient Synthesis of β-Hydroxy-α-amino Acids via C–C Formation, He Y., Li S., Wang J., Yang X., Zhu J., Zhang Q., Cui L., Tan Z., Yan W., Zhang Y., Tang L., Da L*., Feng Y*., 2022
- Algorithm-based Coevolution Network Identification Reveals Key Functional Residues of the α/β Hydrolase Subfamilies, Wu Z., Liu H., Xu L., Chen H., Feng Y*., 2020
- Utility of B-Factors in Protein Science: Interpreting Rigidity, Flexibility, and Internal Motion and Engineering Thermostability, Sun Z., Liu Q., Qu G., Feng Y*., Reetz M*., 2019
- Directed evolution of an α1,3-fucosyltransferase using a single-cell ultrahigh-throughput screening method, Tan Y., Zhang Y., Han Y., Liu H., Chen H., Ma F., Withers S., Feng Y., Yang G.*, 2019
Awards
- DuPont Pioneer Award for Outstanding Contribution in Enzyme Engineering in China
- Shanghai Municipal Technology Invention First Prize and multiple provincial and ministerial scientific and technological progress awards
