Professor | 冯雁 | 数字化转型顾问

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Name	冯雁
Contact Information	yfeng2009@sjtu.edu.cn
Language ability	英语, 汉语
Province	上海

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Name

冯雁

Contact Information

yfeng2009@sjtu.edu.cn

Language ability

英语, 汉语

Province

上海

University/Lab Affiliation and Title	上海交通大学
Faculty	Life Sciences
Academic Background & Achievements	1986年 - 吉林大学分子生物学系学士学位 1994年 - 白求恩医科大学医学博士学位日本国立生命科学和技术研究所博士后研究员（1994-1996年，1998-2000年） 973计划首席科学家，获得教育部新世纪人才、国务院特殊津贴及上海市领军人才等支持和奖励
Work Experience	1989-2008年 - 吉林大学，讲师、副教授、教授，分子酶学工程教育部重点实验室主任 2009年至今 - 上海交通大学特聘教授，博士生导师
Awards	杜邦杰能科中国酶工程杰出贡献奖上海市技术发明一等奖及多项省部级科技进步奖

University/Lab Affiliation and Title

上海交通大学

Faculty

Life Sciences

Academic Background & Achievements

1986年 - 吉林大学分子生物学系学士学位
1994年 - 白求恩医科大学医学博士学位
日本国立生命科学和技术研究所博士后研究员（1994-1996年，1998-2000年）
973计划首席科学家，获得教育部新世纪人才、国务院特殊津贴及上海市领军人才等支持和奖励

Work Experience

1989-2008年 - 吉林大学，讲师、副教授、教授，分子酶学工程教育部重点实验室主任
2009年至今 - 上海交通大学特聘教授，博士生导师

Awards

杜邦杰能科中国酶工程杰出贡献奖
上海市技术发明一等奖及多项省部级科技进步奖

Areas of Focus	分子酶学合成生物学微生物药物合成
Publications	A Validamycin Shunt Pathway for Valienamine Synthesis in Engineered Streptomyces hygroscopicus 5008, Cui L., Wei X., Wang X., Bai L., Lin S., Feng Y., 2020 Structure-guided reshaping of the acyl binding pocket of 'TesAthioesterase enhances octanoic acid production in E. coli, Deng X., Chen L., Hei M., Tian G., Feng Y., Yang G., 2020 Argonaute integrated single-tube PCR system enables supersensitive detection of rare mutations, Liu Q., Guo X., Xun G., Li Z., Chong Y., Yang L., Wang H., Zhang F., Luo S., Cui L., Zhao P., Ye X., Xu H., Lu H., Li X., Deng Z., Li K., Feng Y., 2021 Catalytic properties and biological function of a PIWI-RE nuclease from Pseudomonas stutzeri, Huang F, Xu X.Y., Dong H., Li N., Zhong B.Z., Lu H., Liu Q., Feng Y., 2022 Loosely-packed dynamical structures with partially-melted surface being the key for thermophilic argonaute proteins achieving high DNA-cleavage activity, Zheng L., Lu H., Zan B., Li S., Liu H., Liu Z., Huang.J, Liu Y, Jiang F., Liu Q., Feng Y., Hong L., 2022 Molecular Evolution of an Aminotransferase Based on Substrate–Enzyme Binding Energy Analysis for Efficient Valienamine Synthesis, Cui L., Cui, A., Li Q., Yang L., Liu H., Shao W., Feng Y., 2022 Discovery and Engineering of the l-Threonine Aldolase from Neptunomonas marine for the Efficient Synthesis of β-Hydroxy-α-amino Acids via C–C Formation, He Y., Li S., Wang J., Yang X., Zhu J., Zhang Q., Cui L., Tan Z., Yan W., Zhang Y., Tang L., Da L., Feng Y., 2022 Algorithm-based Coevolution Network Identification Reveals Key Functional Residues of the α/β Hydrolase Subfamilies, Wu Z., Liu H., Xu L., Chen H., Feng Y., 2020 Utility of B-Factors in Protein Science: Interpreting Rigidity, Flexibility, and Internal Motion and Engineering Thermostability, Sun Z., Liu Q., Qu G., Feng Y., Reetz M., 2019 Directed evolution of an α1,3-fucosyltransferase using a single-cell ultrahigh-throughput screening method, Tan Y., Zhang Y., Han Y., Liu H., Chen H., Ma F., Withers S., Feng Y., Yang G.*, 2019

Areas of Focus

分子酶学
合成生物学
微生物药物合成

Publications

A Validamycin Shunt Pathway for Valienamine Synthesis in Engineered Streptomyces hygroscopicus 5008, Cui L., Wei X., Wang X., Bai L., Lin S., Feng Y*., 2020
Structure-guided reshaping of the acyl binding pocket of 'TesAthioesterase enhances octanoic acid production in E. coli, Deng X., Chen L., Hei M., Tian G., Feng Y*., Yang G*., 2020
Argonaute integrated single-tube PCR system enables supersensitive detection of rare mutations, Liu Q., Guo X., Xun G., Li Z., Chong Y., Yang L., Wang H., Zhang F., Luo S., Cui L., Zhao P., Ye X., Xu H., Lu H., Li X., Deng Z., Li K., Feng Y.*, 2021
Catalytic properties and biological function of a PIWI-RE nuclease from Pseudomonas stutzeri, Huang F, Xu X.Y., Dong H., Li N., Zhong B.Z., Lu H., Liu Q., Feng Y.*, 2022
Loosely-packed dynamical structures with partially-melted surface being the key for thermophilic argonaute proteins achieving high DNA-cleavage activity, Zheng L., Lu H., Zan B., Li S., Liu H., Liu Z., Huang.J, Liu Y, Jiang F., Liu Q.*, Feng Y., Hong L.*, 2022
Molecular Evolution of an Aminotransferase Based on Substrate–Enzyme Binding Energy Analysis for Efficient Valienamine Synthesis, Cui L*., Cui, A., Li Q., Yang L., Liu H., Shao W., Feng Y.*, 2022
Discovery and Engineering of the l-Threonine Aldolase from Neptunomonas marine for the Efficient Synthesis of β-Hydroxy-α-amino Acids via C–C Formation, He Y., Li S., Wang J., Yang X., Zhu J., Zhang Q., Cui L., Tan Z., Yan W., Zhang Y., Tang L., Da L*., Feng Y*., 2022
Algorithm-based Coevolution Network Identification Reveals Key Functional Residues of the α/β Hydrolase Subfamilies, Wu Z., Liu H., Xu L., Chen H., Feng Y*., 2020
Utility of B-Factors in Protein Science: Interpreting Rigidity, Flexibility, and Internal Motion and Engineering Thermostability, Sun Z., Liu Q., Qu G., Feng Y*., Reetz M*., 2019
Directed evolution of an α1,3-fucosyltransferase using a single-cell ultrahigh-throughput screening method, Tan Y., Zhang Y., Han Y., Liu H., Chen H., Ma F., Withers S., Feng Y., Yang G.*, 2019

酶分子设计进化微生物基因健康医药合成生物技术

汤立军 - 中南大学

Area of Focus
巨噬细胞 | 防御 | 机制 | 细胞间 | 信息传递 | 分子 | 病理 | 人类 | 疾病 | 重大 | 研究 | 生物 | 细胞 | 健康

蔡煜东 - 上海大学

Area of Focus
癌症 | 基因组学 | 数据分析 | 计算方法 | 生物信息学 | 测序 | 分子生物学 | 健康 | 研究 | 技术 | 微生物 | Covid-19 | 流行病学 | 蛋白质设计 | 分子建模 | 模拟 | 生物学 | 化学 | 机器学习 | 算法 | 人工智能 | 自然计算

李引 - 华中科技大学

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