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Han Xiao
Life Science
Shanghai Jiao Tong University
Shanghai
Language: English, Chinese
Biomanufacturing
Synthetic Biology
Genome Engineering
Genetic Determinants
Chassis Cell
Metabolites
Biosynthesis
Gene Editing
Mushroom
Metabolic Engineering
Areas of Focus
- Efficient Biomanufacturing
- Mushroom Synthetic Biology
- Genome Engineering
Work Experience
- 2015-present - Associate Researcher, Shanghai Jiao Tong University
- 2019-present - PhD Supervisor, Shanghai Jiao Tong University
Academic Background & Achievements
- 2012 - PhD in Microbiology, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences
- Postdoctoral Research at University of Illinois at Urbana-Champaign, USA (2012-2015)
Publications
- Biosynthesis of mushroom-derived type II ganoderic acids by engineered yeast, Wei Yuan, Chenjian Jiang, Qin Wang, Yubo Fang, Jin Wang, Meng Wang, Han Xiao, 2022
- Rational engineering of a membrane-anchored promiscuous cytochrome P450 for efficient biosynthesis of valuable ganoderic acids, Yuhuan Luo, Zeqian Du, Chenjian Jiang, Ziqian Yu, Jian-Jiang Zhong, Ting Shi, Han Xiao, 2023
- The aspartic protease Yps3p and cell wall glucanase Scw10p are novel determinants that enhance the secretion of the anti-tumor triterpenoid GA-HLDOA in Saccharomyces cerevisiae, Yubo Fang, Han Xiao, 2022
- Efficient transport system of cultivated mushroom mycelium enables its derived carbon with high performance electrochemical desalination capability, Chen Zhao, Qin Wang, Shaozhong Chang, Shuo Zhang, Zhonghua Li, Zihan Shen, Xin Jin, Han Xiao, Huigang Zhang, 2022
- Discovery and engineering of cytochrome P450s for terpenoid biosynthesis, Han Xiao, Yue Zhang, Meng Wang, 2019
- Efficient biosynthesis of antitumor ganoderic acid HLDOA using a dual tunable system for optimizing the expression of CYP5150L8 and a Ganoderma P450 reductase, Xiaoting Lan, Wei Yuan, Meng Wang, Han Xiao, 2019
- Biosynthesis of a ganoderic acid in Saccharomyces cerevisiae by expressing a cytochrome P450 gene from Ganoderma lucidum, Wen-Fang Wang, Han Xiao, Jian-Jiang Zhong, 2018
- Genome-scale engineering of Saccharomyces cerevisiae with single nucleotide precision, Zehua Bao, Mohammad HamediRad, Pu Xue, Han Xiao, Ipek Tasan, Ran Chao, Jing Liang, Huimin Zhao, 2018
- CRISPR-Cas9 assisted functional gene editing in the mushroom Ganoderma lucidum, Pingan Wang, Han Xiao, Jian-Jiang Zhong, 2020
- Homology-Integrated CRISPR-Cas (HI-CRISPR) system for one-step multigene disruption in Saccharomyces cerevisiae, Zehua Bao, Han Xiao, Jing Liang, Lu Zhang, Xiong Xiong, Ning Sun, Tong Si, Huimin Zhao, 2015
Awards
- 2017 - Morning Star Outstanding Young Scholar Associate Professor Support Plan (Type B), Shanghai Jiao Tong University
- 2019 - DaSilva Award, Japanese Society for Biotechnology
- 2019, 2020 - Outstanding Class Director, Shanghai Jiao Tong University
- 2023 - Megia Engineering Award, Megia Technology
