2022~Present, Visiting Professor, Xi'an Jiaotong University, First Affiliated Hospital
2021~Present, Associate Professor, Xi'an Jiaotong University, School of Life Sciences
2018~2020, Assistant Professor, Xi'an Jiaotong University, Frontier Institute of Science and Technology
2015~2017, Joint PhD Training, Harvard Medical School, BIDMC
Outstanding Young Scholar of the Biophysical Society of China
First Prize in Shaanxi Provincial Graduate Innovation Achievement Exhibition
Youth Research Scholar of the Oxygen Club of California
Research
Post-translational modifications of proteins Energy metabolism reprogramming Tumor microenvironment Targeted protein degradation drug development Targeted nutrient screening for energy metabolism
MYC induces CDK4/6 inhibitors resistance by promoting pRB1 degradation, J. Ma, L. Li, B.Ma, T. Liu, Z. Wang, Q.Ye, Y. Peng, B.Wang, Y. Chen, S. Xu, K. Wang, F. Dang, X. Wang, Z. Zeng, Y. Jian, Z. Ren, Y. Fan, X. Li, J. Liu, Y. Gao, W. Wei, L. Li, 2024
Targeted protein posttranslational modifications by chemically induced proximity for cancer therapy, Y. Peng, J. Liu, H. Inuzuka, W. Wei, 2023
A liquid biopsy signature for the early-detection of patients with gastric cancer, X. Guo, Y. Peng, Q. Song, J.Wei, X. Wang, Y. Ru, S. Xu, X Cheng, X. Li, D.Wu, L. Chen, B. Wei, X. Lv, Ji, G, 2023
Prostate-specific oncogene OTUD6A promotes prostatic tumorigenesis via deubiquitinating and stabilizing c-Myc, Y. Peng, J. Liu, Z. Wang, C. Cui, T. Zhang, S. Zhang, P. Gao, Z. Hou, H. Liu, J. Guo, J. Zhang, Y. Wen, W. Wei, L. Zhang, J. Liu, J. Long, 2022
Targeting micro-environmental pathways by PROTACs as a therapeutic strategy, J. Liu, Y. Peng, H. Inuzuka, W. Wei, 2022
Daphnetin ameliorates Aβ pathogenesis via STAT3/GFAP signaling in an APP/PS1 double-transgenic mouse model of Alzheimer's disease, P. Gao, Z. Wang, M. Lei, J. Che, S. Zhang, T. Zhang, Y. Hu, L. Shi, L. Cui, J. Liu, M. Noda, Y. Peng, J. Long, 2022
Post-translational modifications on mitochondrial metabolic enzymes in cancer, Y. Peng, H. Liu, J. Liu, J. Long, 2022
Cell cycle on the crossroad of tumorigenesis and cancer therapy, J. Liu, Y. Peng, W. Wei, 2022
Safflower leaf ameliorates cognitive impairment through moderating excessive astrocyte activation in APP/PS1 mice, T. Zhang, S. Zhang, Y. Peng, Y. Wang, P. Gao, Y. Hu, Z. Wang, M. Noda, M. Hiramatsu, J. Liu, J. Long, 2021
Light-controllable PROTACs for temporospatial control of protein degradation, J. Liu, Y. Peng, L. Shi, L. Wan, H. Inuzuka, J. Long, J. Guo, J. Zhang, M. Yuan, S. Zhang, X. Wang, J. Gao, X. Dai, S. Furumoto, L. Jia, P.P. Pandolfi, J.M. Asara, W.G. Kaelin, Jr., J. Liu, W. Wei, 2021
Skp2 dictates cell cycle-dependent metabolic oscillation between glycolysis and TCA cycle, J. Liu, Y. Peng, L. Shi, L. Wan, H. Inuzuka, J. Long, J. Guo, J. Zhang, M. Yuan, S. Zhang, X. Wang, J. Gao, X. Dai, S. Furumoto, L. Jia, P.P. Pandolfi, J.M. Asara, W.G. Kaelin, Jr., J. Liu, W. Wei, 2021
Hydroxytyrosol acetate improves the cognitive function of APP/PS1 transgenic mice in ERβ-dependent manner, C. Qin, S. Hu, S. Zhang, D. Zhao, Y. Wang, H. Li, Y. Peng, L. Shi, X. Xu, C. Wang, J. Liu, Y. Cheng, J. Long, 2021
Central and peripheral metabolic defects contribute to the pathogenesis of Alzheimer's disease: targeting mitochondria for diagnosis and prevention, Y. Peng, P. Gao, L. Shi, L. Chen, J. Liu, J. Long, 2020
The functional analysis of Cullin 7 E3 ubiquitin ligases in cancer, L. Shi, D. Du, Y. Peng, J. Liu, J. Long, 2020
Deubiquitinase OTUD6A promotes proliferation of cancer cells via regulating Drp1 stability and mitochondrial fission, L. Shi, J. Liu, Y. Peng, J. Zhang, X. Dai, S. Zhang, Y. Wang, J. Liu, J. Long, 2020
Targeting SCF E3 ligases for cancer therapies, J. Liu, Y. Peng, J. Zhang, J. Long, J. Liu, W. Wei, 2020
Progress in the use of molecular hydrogen for cancer treatment, D. Du, Y. Peng, J. Liu, J. Long, 2019
Gender difference in the pathogenesis of Alzheimer's disease, Z. Wang, P. Gao, Y. Peng, J. Liu, J. Long, 2019
Hydrogen-rich water improves cognitive impairment gender-dependently in APP/PS1 mice without affecting Aβ clearance, C. Hou, Y. Peng, C. Qin, F. Fan, J. Liu, J. Long, 2018
Early interleukin-6 enhances hepatic ketogenesis in APP(SWE)/PSEN1dE9 mice via 3-hydroxy-3-methylglutary-CoA synthase 2 signaling activation by p38/nuclear factor κB p65, L. Shi, D. Zhao, C. Hou, Y. Peng, J. Liu, S. Zhang, J. Liu, J. Long, 2017
Endogenously generated amyloid-β increases stiffness in human neuroblastoma cells, Z. Lu, H. Li, C. Hou, Y. Peng, J. Long, J. Liu, 2017
Hydroxytyrosol mildly improve cognitive function independent of APP processing in APP/PS1 mice, Y. Peng, C. Hou, Z. Yang, C. Li, L. Jia, J. Liu, Y. Tang, L. Shi, Y. Li, J. Long, J. Liu, 2016
Mitochondrial dysfunction precedes depression of AMPK/AKT signaling in insulin resistance induced by high glucose in primary cortical neurons, Y. Peng, J. Liu, L. Shi, Y. Tang, D. Gao, J. Long, J. Liu, 2016
Mitochondrial dysfunction launches dexamethasone-induced skeletal muscle atrophy via AMPK/FOXO3 signaling, J. Liu, Y. Peng, X. Wang, Y. Fan, C. Qin, L. Shi, Y. Tang, K. Cao, H. Li, J. Long, J. Liu, 2016
Early inflammation-associated factors blunt sterol regulatory element-binding proteins-1-mediated lipogenesis in high-fat diet-fed APP(SWE) /PSEN1dE9 mouse model of Alzheimer's disease, Y. Tang, Y. Peng, J. Liu, L. Shi, Y. Wang, J. Long, J. Liu, 2016
Hydroxytyrosol improves mitochondrial function and reduces oxidative stress in the brain of db/db mice: role of AMP-activated protein kinase activation, A. Zheng, H. Li, J. Xu, K. Cao, H. Li, W. Pu, Z. Yang, Y. Peng, J. Long, J. Liu, Z. Feng, 2015
High-fat-diet-induced weight gain ameliorates bone loss without exacerbating AβPP processing and cognition in female APP/PS1 mice, Y. Peng, J. Liu, Y. Tang, J. Liu, T. Han, S. Han, H. Li, C. Hou
Keywords
PhosphorylationUbiquitinationDeubiquitinationProtein DegradationCancer TherapyMetabolic ReprogrammingTumor EnvironmentDrug DevelopmentNutrient ScreeningMitochondrial Function
Area of Focus
Anticancer | Biomolecular | Drug Development | Protein Design | Synthesis | Molecular Biology | Structural Biology | Cancer Therapy | Pharmaceuticals | Biochemistry
