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Xiaofeng Chen
Life Science
Xi'an Jiaotong University
Shaanxi
Language: Chinese, English
Genetics
Bioinformatics
Molecular Biology
Complex Diseases
Genetic Markers
Regulatory Mechanisms
Multi-Omics
High-Throughput
Sequencing
Disease Mechanisms
Areas of Focus
- Genetic susceptibility markers for complex diseases
- Molecular genetic regulatory mechanisms
- Development of multi-omics integration methods
- High-throughput regulatory element sequencing
Work Experience
- 2024-Present - Xi'an Jiaotong University, School of Life Sciences and Technology - Associate Professor, Master's Supervisor
- 2020-2024 - Xi'an Jiaotong University, School of Life Sciences and Technology - Assistant Professor
Academic Background & Achievements
- 2024-Present: Associate Professor, Master's Supervisor at Xi'an Jiaotong University, School of Life Sciences and Technology
- 2020-2024: Assistant Professor at Xi'an Jiaotong University, School of Life Sciences and Technology
- 2014-2020: PhD in Biology, Xi'an Jiaotong University, School of Life Sciences and Technology
- 2010-2014: Bachelor of Bioengineering, Xi'an Jiaotong University, School of Life Sciences and Technology
Publications
- Integrative high-throughput enhancer surveying and functional verification divulges a YY2-condensed regulatory axis conferring risk for osteoporosis, Chen XF, Duan YY, Jia YY, Dong QH, Shi W, Zhang Y, Dong SS, Li M, Liu ZB, Chen F, Huang XT, Hao RH, Zhu DL, Jing RH, Guo Y, Yang TL, 2024
- High-throughput functional dissection of noncoding SNPs with biased allelic enhancer activity for insulin resistance-relevant phenotypes, Duan YY, Chen XF, Zhu RJ, Jia YY, Huang XT, Zhang M, Yang N, Dong SS, Zeng M, Feng Z, Zhu DL, Wu H, Jiang F, Shi W, Hu WX, Ke X, Chen H, Liu Y, Jing RH, Guo Y, Li M, Yang TL, 2023
- Assessment of bidirectional relationships between brain imaging-derived phenotypes and stroke: a Mendelian randomization study, Yu K, Chen XF, Guo J, Wang S, Huang XT, Guo Y, Dong SS, Yang TL, 2023
- Multiomics dissection of molecular regulatory mechanisms underlying autoimmune-associated noncoding SNPs, Chen XF, Guo MR, Duan YY, Jiang F, Wu H, Dong SS, Zhou XR, Thynn HN, Liu CC, Zhang L, Guo Y, Yang TL, 2020
- An allele-specific functional SNP associated with two systemic autoimmune diseases modulates IRF5 expression by long-range chromatin loop formation, Thynn HN, Chen XF, Hu WX, Duan YY, Zhu DL, Chen H, Wang NN, Chen HH, Rong Y, Lu BJ, Yang M, Jiang F, Dong SS, Guo Y, Yang TL, 2020
- An Osteoporosis Risk SNP at 1p36.12 Acts as an Allele-Specific Enhancer to Modulate LINC00339 Expression via Long-Range Loop Formation, Chen XF, Zhu DL, Yang M, Hu WX, Duan YY, Lu BJ, Rong Y, Dong SS, Hao RH, Chen JB, Chen YX, Yao S, Thynn HN, Guo Y, Yang TL, 2018
- Multiple functional variants at the 13q14 risk locus for osteoporosis regulate RANKL expression through long-range super-enhancer, Zhu DL, Chen XF, Hu WX, Dong SS, Lu BJ, Rong Y, Chen YX, Chen H, Thynn HN, Wang NN, Guo Y, Yang TL, 2018
Awards
- 2022: Shaanxi Province Outstanding Doctoral Thesis
- 2022: Shaanxi Higher Education Outstanding Scientific Research Achievement Award - Special Prize
- 2020: Xi'an Jiaotong University Young Talent Support Plan - Category A
