Areas of Focus
- 复杂疾病的遗传易感标记
- 分子遗传学调控机制
- 多组学整合方法开发
- 高通量调控元件测序
Work Experience
- 2024-至今 - 西安交通大学生命科学与技术学院 - 副教授, 硕士生导师
- 2020-2024 - 西安交通大学生命科学与技术学院 - 助理教授
Academic Background & Achievements
- 2024-至今: 西安交通大学生命科学与技术学院副教授, 硕士生导师
- 2020-2024: 西安交通大学生命科学与技术学院助理教授
- 2014-2020: 西安交通大学生命科学与技术学院生物学理学博士
- 2010-2014: 西安交通大学生命科学与技术学院生物工程工学学士
Publications
- Integrative high-throughput enhancer surveying and functional verification divulges a YY2-condensed regulatory axis conferring risk for osteoporosis, Chen XF, Duan YY, Jia YY, Dong QH, Shi W, Zhang Y, Dong SS, Li M, Liu ZB, Chen F, Huang XT, Hao RH, Zhu DL, Jing RH, Guo Y, Yang TL, 2024
- High-throughput functional dissection of noncoding SNPs with biased allelic enhancer activity for insulin resistance-relevant phenotypes, Duan YY, Chen XF, Zhu RJ, Jia YY, Huang XT, Zhang M, Yang N, Dong SS, Zeng M, Feng Z, Zhu DL, Wu H, Jiang F, Shi W, Hu WX, Ke X, Chen H, Liu Y, Jing RH, Guo Y, Li M, Yang TL, 2023
- Assessment of bidirectional relationships between brain imaging-derived phenotypes and stroke: a Mendelian randomization study, Yu K, Chen XF, Guo J, Wang S, Huang XT, Guo Y, Dong SS, Yang TL, 2023
- Multiomics dissection of molecular regulatory mechanisms underlying autoimmune-associated noncoding SNPs, Chen XF, Guo MR, Duan YY, Jiang F, Wu H, Dong SS, Zhou XR, Thynn HN, Liu CC, Zhang L, Guo Y, Yang TL, 2020
- An allele-specific functional SNP associated with two systemic autoimmune diseases modulates IRF5 expression by long-range chromatin loop formation, Thynn HN, Chen XF, Hu WX, Duan YY, Zhu DL, Chen H, Wang NN, Chen HH, Rong Y, Lu BJ, Yang M, Jiang F, Dong SS, Guo Y, Yang TL, 2020
- An Osteoporosis Risk SNP at 1p36.12 Acts as an Allele-Specific Enhancer to Modulate LINC00339 Expression via Long-Range Loop Formation, Chen XF, Zhu DL, Yang M, Hu WX, Duan YY, Lu BJ, Rong Y, Dong SS, Hao RH, Chen JB, Chen YX, Yao S, Thynn HN, Guo Y, Yang TL, 2018
- Multiple functional variants at the 13q14 risk locus for osteoporosis regulate RANKL expression through long-range super-enhancer, Zhu DL, Chen XF, Hu WX, Dong SS, Lu BJ, Rong Y, Chen YX, Chen H, Thynn HN, Wang NN, Guo Y, Yang TL, 2018
Awards
- 2022: 陕西省优秀博士论文
- 2022: 陕西高等学校科学技术研究优秀成果奖-特等奖
- 2020: 西安交通大学青年优秀人才支持计划-A类