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Tianlong Zhang
Medicine
Shanghai University
Shanghai
Language: Chinese, English
Biochemistry
Molecular Biology
Structural Biology
Cell Biology
Aging
Cancer
Diabetes
Signaling Pathways
Molecular Mechanisms
Drug Targets
Areas of Focus
- Biochemistry, Molecular Biology, Structural Biology, and Cell Biology
- Research on signaling pathways related to aging, cancer, and diabetes
- Study of molecular mechanisms and drug target discovery
Work Experience
- 2009-2021 Assistant Researcher, Associate Researcher, Researcher at Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences
- 2021-Present Researcher at Shanghai University Medical School
Academic Background & Achievements
- 1998-2002 Bachelor's Degree: Nanjing University
- 2003-2009 PhD: Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences
- Published over 30 academic papers
- First author or corresponding author in high-impact journals
- Recipient of national and academy-level research grants
Publications
- Molecular mechanism of the S-adenosylmethionine sensing by SAMTOR in mTORC1 signaling, X. Tang, Y. Zhang, G. Wang, C. Zhang, F. Wang, J. Shi, T. Zhang, J. Ding
- Identification and Tetramer Structure of Hemin-Binding Protein SPD_0310 Linked to Iron Homeostasis and Virulence of Streptococcus pneumoniae, K. Cao, T. Zhang, Nan Li, X. Yang, J. Ding, Q. He, X. Sun
- Nde1 is a Rab9 effector for loading late endosomes to cytoplasmic dynein motor complex, Y. Zhang, Z. Chen, F. Wang, H. Sun, X. Zhu, J. Ding, T. Zhang
- Structural basis for self-cleavage prevention by tag:anti-tag pairing complementary in type VI Cas13 CRISPR systems, B. Wang, T. Zhang, J. Yin, Y. Yu, W. Xu, J. Ding, D. J. Patel, H. Yang
- Crystal structures of algal TET homologue CMD1 provide insight into the molecular mechanism for vitamin C-derived C5-glyceryl-methylcytosine DNA modification, W. Li, T. Zhang, M. Sun, Y. Shi, X. Zhang, G. Xu, J. Ding
- Structural insights into the EGO-TC-mediated membrane tethering of the TORC1-regulatory Rag GTPases, T. Zhang, M.P. Péli-Gulli, Z. Zhang, X. Tang, J. Ye, C. De Virgilio, J. Ding
- Structural basis for Ragulator functioning as a scaffold in membrane-anchoring of Rag GTPases and mTORC1, T. Zhang, R. Wang, Z. Wang, X. Wang, F. Wang, J. Ding
- Structural basis for targeting BIG1 to Golgi apparatus through interaction of its DCB domain with Arl1, R. Wang, Z. Wang, K. Wang, T. Zhang, J. Ding
- Structural insight into the arginine-binding specificity of CASTOR1 in amino acid-dependent mTORC1 signaling, J. Xia, R. Wang, T. Zhang, J. Ding
- Crystal structure of the Ego1-Ego2-Ego3 complex and its role in promoting Rag GTPase-dependent TORC1 signaling, K. Powis, T. Zhang, N. Panchaud, R. Wang, C. De Virgilio, J. Ding
Awards
- Member of the Youth Innovation Promotion Association, Chinese Academy of Sciences
- Recipient of the Sanofi-Beauty Young Talent Award
