Professor | Yeguang Chen | Asia Growth Partners

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Name	Yeguang Chen
Contact Information	ygchen@tsinghua.edu.cn
Language ability	English, Chinese
Province	Beijing

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Name

Yeguang Chen

Contact Information

ygchen@tsinghua.edu.cn

Language ability

English, Chinese

Province

Beijing

University/Lab Affiliation and Title	Tsinghua University
Faculty	Life Sciences
Academic Background & Achievements	1979-1983 Bachelor of Biology: Jiangxi University (Nanchang University) 1983-1986 Master of Zoology: Jiangxi University (Nanchang University) 1988-1990 Master of Cell Biology: Fordham University, USA 1991-1996 PhD in Cell Biology: Albert Einstein College of Medicine, USA Member of the Chinese Academy of Sciences Member of the Academy of Sciences for the Developing World
Work Experience	1996-2000 Postdoctoral Researcher: Howard Hughes Medical Institute, Sloan-Kettering Cancer Center, USA 2000-2002 Assistant Professor: University of California, Riverside, USA 2002-present Professor: Tsinghua University, School of Life Sciences

University/Lab Affiliation and Title

Tsinghua University

Faculty

Life Sciences

Academic Background & Achievements

1979-1983 Bachelor of Biology: Jiangxi University (Nanchang University)
1983-1986 Master of Zoology: Jiangxi University (Nanchang University)
1988-1990 Master of Cell Biology: Fordham University, USA
1991-1996 PhD in Cell Biology: Albert Einstein College of Medicine, USA
Member of the Chinese Academy of Sciences
Member of the Academy of Sciences for the Developing World

Work Experience

1996-2000 Postdoctoral Researcher: Howard Hughes Medical Institute, Sloan-Kettering Cancer Center, USA
2000-2002 Assistant Professor: University of California, Riverside, USA
2002-present Professor: Tsinghua University, School of Life Sciences

Areas of Focus	Molecular biology, cell biology, bioinformatics, organoid technology, omics testing, animal models, TGF-β, Wnt, BMP signaling, adult stem cell renewal, disease mechanisms
Publications	HER2 phosphorylation induced by TGF-β promotes mammary morphogenesis and breast cancer progression, Shi QN, Huang F, Wang YL, Deng HT, Chen YG, 2024 Tumorigenicity and prediction of clinical prognosis chemotherapy response of patient-derived gastric cancer organoids, Wang T, Song WL, Meng QY, Qu CQ, GuoSH, Wang YL, Tan RH, Jia BQ, Chen YG, 2024 Stromal BMP signaling regulates mucin production in the large intestine via interleukin-1/17, Wang YL, Lou RY, Zhang Z, Xiao CY, Yu SC, Wei ST, Liu Y, Fu W, Li BJ, Chen YG, 2023 TGF-β promotes inflammation and tumorigenesis in Smad4-deficient intestinal epithelium in a YAP-dependent manner, Liu LS, Wang YL, Yu SC, Liu HD, Li YH, Hua S, Chen YG, 2023 MicroRNA-200 loaded lipid nanoparticles promote intestinal epithelium regeneration in canonical microRNAs-deficient mice, Wei XY, Yu SC, Zhang TH, Liu LS, Wang X, Wang XD, Chan YS, Wang YM, Meng S, Chen YG, 2023 Dishevelled phase separation promotes Wnt signalosome assembly and destruction complex disassembly, Kang KX, Shi QN, Wang X, Chen YG, 2022 Phase separation of Axin organizes the β-catenin destruction complex, Nong JX, Kang KX, Shi QN, Zhu XC, Tao QH, Chen YG, 2021 Establishment of human distal lung organoids for SARS-CoV-2 infection, Wang T, Zhang N, Fan SP, Zhao LZ, Song WL, Gong YH, Shen Q, Zhang C, Ren P, Lin CT, Fu W, Gao G, Ma SH, Bi YH, Chen YG, 2021 Single-cell transcriptome analysis reveals differential nutrient absorption functions in human intestine, Wang YL, Song WL, Wang JL, Wang T, Xiong XC, Qi Z, Fu W, Yang XR, Chen YG, 2020 DNA Damage Activates TGF-β Signaling via ATM-c-Cbl-Mediated Stabilization of the Type II Receptor TβRII, Li YZ, Liu Y, Y. Jeffrey Chiang, Huang F, Li YH, Li XT, Ning YH, Zhang WH, Deng HT, Chen YG, 2019

Areas of Focus

Molecular biology, cell biology, bioinformatics, organoid technology, omics testing, animal models, TGF-β, Wnt, BMP signaling, adult stem cell renewal, disease mechanisms

Publications

HER2 phosphorylation induced by TGF-β promotes mammary morphogenesis and breast cancer progression, Shi QN, Huang F, Wang YL, Deng HT, Chen YG, 2024
Tumorigenicity and prediction of clinical prognosis chemotherapy response of patient-derived gastric cancer organoids, Wang T, Song WL, Meng QY, Qu CQ, GuoSH, Wang YL, Tan RH, Jia BQ, Chen YG, 2024
Stromal BMP signaling regulates mucin production in the large intestine via interleukin-1/17, Wang YL, Lou RY, Zhang Z, Xiao CY, Yu SC, Wei ST, Liu Y, Fu W, Li BJ, Chen YG, 2023
TGF-β promotes inflammation and tumorigenesis in Smad4-deficient intestinal epithelium in a YAP-dependent manner, Liu LS, Wang YL, Yu SC, Liu HD, Li YH, Hua S, Chen YG, 2023
MicroRNA-200 loaded lipid nanoparticles promote intestinal epithelium regeneration in canonical microRNAs-deficient mice, Wei XY, Yu SC, Zhang TH, Liu LS, Wang X, Wang XD, Chan YS, Wang YM, Meng S, Chen YG, 2023
Dishevelled phase separation promotes Wnt signalosome assembly and destruction complex disassembly, Kang KX, Shi QN, Wang X, Chen YG, 2022
Phase separation of Axin organizes the β-catenin destruction complex, Nong JX, Kang KX, Shi QN, Zhu XC, Tao QH, Chen YG, 2021
Establishment of human distal lung organoids for SARS-CoV-2 infection, Wang T, Zhang N, Fan SP, Zhao LZ, Song WL, Gong YH, Shen Q, Zhang C, Ren P, Lin CT, Fu W, Gao G, Ma SH, Bi YH, Chen YG, 2021
Single-cell transcriptome analysis reveals differential nutrient absorption functions in human intestine, Wang YL, Song WL, Wang JL, Wang T, Xiong XC, Qi Z, Fu W, Yang XR, Chen YG, 2020
DNA Damage Activates TGF-β Signaling via ATM-c-Cbl-Mediated Stabilization of the Type II Receptor TβRII, Li YZ, Liu Y, Y. Jeffrey Chiang, Huang F, Li YH, Li XT, Ning YH, Zhang WH, Deng HT, Chen YG, 2019

Molecular Biology Cell Biology Bioinformatics Organoid Technology Omics Testing Animal Models Tgf-Β Wnt Bmp Signaling Stem Cell Renewal

Ma Long - Central South University

Chen Fuxue - Shanghai University

Yeguang Chen - Tsinghua University

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