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Sai Li
Life Science
Tsinghua University
Beijing
Language: English, Chinese, German
Cryo-Et
High-Resolution
Structural Biology
Virus
Cell Imaging
Molecular Structure
In Situ
Clem
Cryo-Fib
Biophysics
Areas of Focus
- High-resolution cryo-electron tomography (cryo-ET) methods
- Structural and functional studies of emerging enveloped viruses
Work Experience
- 2013-2017 - University of Oxford, STRUBI, Postdoctoral Researcher
- 2017-2018 - University of Oxford, STRUBI, Senior Research Associate
- 2018-present - Tsinghua University, Assistant Professor/Associate Professor
- 2018-present - Joint Center for Life Sciences, Tsinghua-Peking, Researcher
Academic Background & Achievements
- 2002-2006 Bachelor: Wuhan University, Applied Physics
- 2006-2008 Master: University of Stuttgart, Physics
- 2009-2012 PhD: University of Göttingen, Biophysics
Publications
- In situ architecture and membrane fusion of SARS-CoV-2 Delta variant, Sai Li et al., 2023
- Toward Atomistic Models of Intact SARS-CoV-2 via Martini Coarse-Grained Molecular Dynamics Simulations, Sai Li et al., 2023
- Cryo-electron tomography: the resolution revolution and a surge of in situ virological discoveries, Sai Li et al., 2023
- Cryo-electron tomography of enveloped viruses, Sai Li, 2022
- Site-specific steric control of SARS-CoV-2 spike glycosylation, Sai Li et al., 2021
- Molecular architecture of the SARS-CoV-2 virus, Sai Li et al., 2020
- PSGL-1 inhibits HIV-1 infection by restricting actin dynamics and sequestering HIV envelope proteins, Sai Li et al., 2020
- Packaging and delivering enzymes by amorphous metal-organic frameworks, Sai Li et al., 2019
