Professor | Junjie Liu | Asia Growth Partners

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Name	Junjie Liu
Contact Information	junjiegogoliu@tsinghua.edu.cn
Language ability	English, Chinese
Province	Beijing

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Name

Junjie Liu

Contact Information

junjiegogoliu@tsinghua.edu.cn

Language ability

English, Chinese

Province

Beijing

University/Lab Affiliation and Title	Tsinghua University
Faculty	Life Sciences
Academic Background & Achievements	2007-2011 Bachelor: Sichuan University, School of Life Sciences 2011-2016 PhD: Tsinghua University, School of Life Sciences
Work Experience	2016-2018 Postdoctoral Researcher: Lawrence Berkeley National Lab - Biophysics and Bioimaging Center 2018-2020 Postdoctoral Researcher: University of California, Berkeley - Department of Cell and Molecular Biology 2020-present Assistant Professor, Associate Professor: Tsinghua University, School of Life Sciences 2020-present Researcher: Tsinghua-Peking Joint Center for Life Sciences, Beijing Advanced Innovation Center for Structural Biology

University/Lab Affiliation and Title

Tsinghua University

Faculty

Life Sciences

Academic Background & Achievements

Work Experience

2016-2018 Postdoctoral Researcher: Lawrence Berkeley National Lab - Biophysics and Bioimaging Center
2018-2020 Postdoctoral Researcher: University of California, Berkeley - Department of Cell and Molecular Biology
2020-present Assistant Professor, Associate Professor: Tsinghua University, School of Life Sciences
2020-present Researcher: Tsinghua-Peking Joint Center for Life Sciences, Beijing Advanced Innovation Center for Structural Biology

Areas of Focus	Design and development of novel gene editing tools Mechanistic studies of RNA-related nucleic acid enzymes
Publications	Hydrolytic endonucleolytic ribozyme (HYER) is programmable for sequence-specific DNA cleavage, Liu JJ, 2024 Structural RNA components supervise the sequential DNA cleavage in R2 retrotransposon, Liu JJ, 2023 Nucleases in gene-editing technologies: past and prologue, Liu JJ, 2023 Regulation of the CRISPR-Cas12a system by methylation and demethylation of guide RNA, Liu JJ, 2023 The compact Casπ (Cas12l) ‘bracelet’ provides a unique structural platform for DNA manipulation, Liu JJ, 2023 Chimeric CRISPR-CasX enzymes and guide RNAs for improved genome editing activity, Liu JJ, 2022 Nonspecific interactions between SpCas9 and dsDNA sites located downstream of the PAM mediate facilitated diffusion to accelerate target search, Liu JJ, 2021 Cryo-Electron Microscopy of Endogenous Yeast Exosomes, Liu JJ, 2020 Target preference of Type III-A CRISPR-Cas complexes at the transcription bubble, Liu JJ, 2019 CasX enzymes comprise a distinct family of RNA-guided genome editors, Liu JJ, 2019 Temperature-Responsive Competitive Inhibition of CRISPR-Cas9, Liu JJ, 2019 Structures of the CRISPR genome integration complex, Liu JJ, 2017

Areas of Focus

Design and development of novel gene editing tools
Mechanistic studies of RNA-related nucleic acid enzymes

Publications

Hydrolytic endonucleolytic ribozyme (HYER) is programmable for sequence-specific DNA cleavage, Liu JJ*, 2024
Structural RNA components supervise the sequential DNA cleavage in R2 retrotransposon, Liu JJ*, 2023
Nucleases in gene-editing technologies: past and prologue, Liu JJ*, 2023
Regulation of the CRISPR-Cas12a system by methylation and demethylation of guide RNA, Liu JJ*, 2023
The compact Casπ (Cas12l) ‘bracelet’ provides a unique structural platform for DNA manipulation, Liu JJ*, 2023
Chimeric CRISPR-CasX enzymes and guide RNAs for improved genome editing activity, Liu JJ*, 2022
Nonspecific interactions between SpCas9 and dsDNA sites located downstream of the PAM mediate facilitated diffusion to accelerate target search, Liu JJ*, 2021
Cryo-Electron Microscopy of Endogenous Yeast Exosomes, Liu JJ*, 2020
Target preference of Type III-A CRISPR-Cas complexes at the transcription bubble, Liu JJ*, 2019
CasX enzymes comprise a distinct family of RNA-guided genome editors, Liu JJ*, 2019
Temperature-Responsive Competitive Inhibition of CRISPR-Cas9, Liu JJ*, 2019
Structures of the CRISPR genome integration complex, Liu JJ*, 2017

Gene Editing Crispr Cas Systems Nucleases Biotechnology Molecular Biology Genetics Rna Mechanisms Enzyme Research Biomedical Engineering

Meihua Yu - Shanghai University

Xiaojun Feng - Huazhong University of Science and Technology

Jinling Lu - Huazhong University of Science and Technology

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