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Junjie Liu
Life Science
Tsinghua University
Beijing
Language: English, Chinese
Gene Editing
Crispr
Cas Systems
Nucleases
Biotechnology
Molecular Biology
Genetics
Rna Mechanisms
Enzyme Research
Biomedical Engineering
Areas of Focus
- Design and development of novel gene editing tools
- Mechanistic studies of RNA-related nucleic acid enzymes
Work Experience
- 2016-2018 Postdoctoral Researcher: Lawrence Berkeley National Lab - Biophysics and Bioimaging Center
- 2018-2020 Postdoctoral Researcher: University of California, Berkeley - Department of Cell and Molecular Biology
- 2020-present Assistant Professor, Associate Professor: Tsinghua University, School of Life Sciences
- 2020-present Researcher: Tsinghua-Peking Joint Center for Life Sciences, Beijing Advanced Innovation Center for Structural Biology
Academic Background & Achievements
- 2007-2011 Bachelor: Sichuan University, School of Life Sciences
- 2011-2016 PhD: Tsinghua University, School of Life Sciences
Publications
- Hydrolytic endonucleolytic ribozyme (HYER) is programmable for sequence-specific DNA cleavage, Liu JJ*, 2024
- Structural RNA components supervise the sequential DNA cleavage in R2 retrotransposon, Liu JJ*, 2023
- Nucleases in gene-editing technologies: past and prologue, Liu JJ*, 2023
- Regulation of the CRISPR-Cas12a system by methylation and demethylation of guide RNA, Liu JJ*, 2023
- The compact Casπ (Cas12l) ‘bracelet’ provides a unique structural platform for DNA manipulation, Liu JJ*, 2023
- Chimeric CRISPR-CasX enzymes and guide RNAs for improved genome editing activity, Liu JJ*, 2022
- Nonspecific interactions between SpCas9 and dsDNA sites located downstream of the PAM mediate facilitated diffusion to accelerate target search, Liu JJ*, 2021
- Cryo-Electron Microscopy of Endogenous Yeast Exosomes, Liu JJ*, 2020
- Target preference of Type III-A CRISPR-Cas complexes at the transcription bubble, Liu JJ*, 2019
- CasX enzymes comprise a distinct family of RNA-guided genome editors, Liu JJ*, 2019
- Temperature-Responsive Competitive Inhibition of CRISPR-Cas9, Liu JJ*, 2019
- Structures of the CRISPR genome integration complex, Liu JJ*, 2017
