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Yi Xue
Life Science
Tsinghua University
Beijing
Language: Chinese, English
Non-Coding Rna
Intrinsically Disordered Proteins
Nmr Technology
Molecular Dynamics Simulation
Rna-Protein Complexes
3D Structure
Conformational Changes
Computational Methods
Structural Modeling
Drug Screening
Areas of Focus
- Non-coding RNA and intrinsically disordered proteins: structure and dynamics
- Development of new NMR techniques, sample labeling methods, and computational tools
- Structural modeling of highly variable biomolecules and high-throughput drug screening
Work Experience
- 1997-1999 - Fujian Sida Computer Company - Engineer
- 2010-2013 - Department of Chemistry, Purdue University - Postdoctoral Researcher
- 2013-2016 - University of Michigan, Duke University - Postdoctoral Researcher
- 2016-2024 - School of Life Sciences, Tsinghua University - Assistant Professor
- 2024-present - School of Life Sciences, Tsinghua University - Associate Professor
Academic Background & Achievements
- 1993-1997 Bachelor: Department of Modern Applied Physics, Tsinghua University
- 2000-2003 Master: Department of Biological Science and Technology, Tsinghua University
- 2004-2009 PhD: Department of Chemistry, Purdue University
Publications
- Simulating diffraction photographs based on molecular dynamics trajectories of a protein crystal: a new option to examine structure-solving strategies in protein crystallography, Liu N, Mikhailovskii O, Skrynnikov NR, Xue Y, 2023
- Antiviral drug design based on structural insights into the N-terminal domain and C-terminal domain of the SARS-CoV-2 nucleocapsid protein, Luan X, Li X, Li Y, Su G, Yin W, Jiang Y, Xu N, Wang F, Cheng W, Jin Y, Zhang L, Xu HE, Xue Y, Zhang S, 2022
- Insights into the client protein release mechanism of the ATP-independent chaperone Spy, He W, Li X, Xue H, Yang Y, Mencius J, Bai L, Zhang J, Xu J, Wu B, Xue Y, Quan S, 2022
- Rational design of hairpin RNA excited states reveals multi-step transitions, Han G, Xue Y, 2022
- NADPH levels affect cellular epigenetic state by inhibiting HDAC3–Ncor complex, Li W, Kou J, Qin J, Li L, Zhang Z, Pan Y, Xue Y, Du W, 2021
- Characteristic chemical probing patterns of loop motifs improve prediction accuracy of RNA secondary structures, Cao J, Xue Y, 2021
- Chemical shift prediction of RNA imino groups: application toward characterizing RNA excited states, Wang Y, Han G, Jiang X, Yuwen T, Xue Y, 2021
- The microtubule end-binding affinity of EB1 is enhanced by a dimeric organization that is susceptible to phosphorylation, Song Y, Zhang Y, Pan Y, He J, Wang Y, Chen W, Guo J, Deng H, Xue Y, Fang X, Liang X, 2020
