Professor | Yi Xue | Asia Growth Partners

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Name	Yi Xue
Contact Information	yixue@mail.tsinghua.edu.cn
Language ability	Chinese, English
Province	Beijing

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Name

Yi Xue

Contact Information

yixue@mail.tsinghua.edu.cn

Language ability

Chinese, English

Province

Beijing

University/Lab Affiliation and Title	Tsinghua University
Faculty	Life Sciences
Academic Background & Achievements	1993-1997 Bachelor: Department of Modern Applied Physics, Tsinghua University 2000-2003 Master: Department of Biological Science and Technology, Tsinghua University 2004-2009 PhD: Department of Chemistry, Purdue University
Work Experience	1997-1999 - Fujian Sida Computer Company - Engineer 2010-2013 - Department of Chemistry, Purdue University - Postdoctoral Researcher 2013-2016 - University of Michigan, Duke University - Postdoctoral Researcher 2016-2024 - School of Life Sciences, Tsinghua University - Assistant Professor 2024-present - School of Life Sciences, Tsinghua University - Associate Professor

University/Lab Affiliation and Title

Tsinghua University

Faculty

Life Sciences

Academic Background & Achievements

1993-1997 Bachelor: Department of Modern Applied Physics, Tsinghua University
2000-2003 Master: Department of Biological Science and Technology, Tsinghua University
2004-2009 PhD: Department of Chemistry, Purdue University

Work Experience

1997-1999 - Fujian Sida Computer Company - Engineer
2010-2013 - Department of Chemistry, Purdue University - Postdoctoral Researcher
2013-2016 - University of Michigan, Duke University - Postdoctoral Researcher
2016-2024 - School of Life Sciences, Tsinghua University - Assistant Professor
2024-present - School of Life Sciences, Tsinghua University - Associate Professor

Areas of Focus	Non-coding RNA and intrinsically disordered proteins: structure and dynamics Development of new NMR techniques, sample labeling methods, and computational tools Structural modeling of highly variable biomolecules and high-throughput drug screening
Publications	Simulating diffraction photographs based on molecular dynamics trajectories of a protein crystal: a new option to examine structure-solving strategies in protein crystallography, Liu N, Mikhailovskii O, Skrynnikov NR, Xue Y, 2023 Antiviral drug design based on structural insights into the N-terminal domain and C-terminal domain of the SARS-CoV-2 nucleocapsid protein, Luan X, Li X, Li Y, Su G, Yin W, Jiang Y, Xu N, Wang F, Cheng W, Jin Y, Zhang L, Xu HE, Xue Y, Zhang S, 2022 Insights into the client protein release mechanism of the ATP-independent chaperone Spy, He W, Li X, Xue H, Yang Y, Mencius J, Bai L, Zhang J, Xu J, Wu B, Xue Y, Quan S, 2022 Rational design of hairpin RNA excited states reveals multi-step transitions, Han G, Xue Y, 2022 NADPH levels affect cellular epigenetic state by inhibiting HDAC3–Ncor complex, Li W, Kou J, Qin J, Li L, Zhang Z, Pan Y, Xue Y, Du W, 2021 Characteristic chemical probing patterns of loop motifs improve prediction accuracy of RNA secondary structures, Cao J, Xue Y, 2021 Chemical shift prediction of RNA imino groups: application toward characterizing RNA excited states, Wang Y, Han G, Jiang X, Yuwen T, Xue Y, 2021 The microtubule end-binding affinity of EB1 is enhanced by a dimeric organization that is susceptible to phosphorylation, Song Y, Zhang Y, Pan Y, He J, Wang Y, Chen W, Guo J, Deng H, Xue Y, Fang X, Liang X, 2020

Areas of Focus

Non-coding RNA and intrinsically disordered proteins: structure and dynamics
Development of new NMR techniques, sample labeling methods, and computational tools
Structural modeling of highly variable biomolecules and high-throughput drug screening

Publications

Simulating diffraction photographs based on molecular dynamics trajectories of a protein crystal: a new option to examine structure-solving strategies in protein crystallography, Liu N, Mikhailovskii O, Skrynnikov NR, Xue Y, 2023
Antiviral drug design based on structural insights into the N-terminal domain and C-terminal domain of the SARS-CoV-2 nucleocapsid protein, Luan X, Li X, Li Y, Su G, Yin W, Jiang Y, Xu N, Wang F, Cheng W, Jin Y, Zhang L, Xu HE, Xue Y, Zhang S, 2022
Insights into the client protein release mechanism of the ATP-independent chaperone Spy, He W, Li X, Xue H, Yang Y, Mencius J, Bai L, Zhang J, Xu J, Wu B, Xue Y, Quan S, 2022
Rational design of hairpin RNA excited states reveals multi-step transitions, Han G, Xue Y, 2022
NADPH levels affect cellular epigenetic state by inhibiting HDAC3–Ncor complex, Li W, Kou J, Qin J, Li L, Zhang Z, Pan Y, Xue Y, Du W, 2021
Characteristic chemical probing patterns of loop motifs improve prediction accuracy of RNA secondary structures, Cao J, Xue Y, 2021
Chemical shift prediction of RNA imino groups: application toward characterizing RNA excited states, Wang Y, Han G, Jiang X, Yuwen T, Xue Y, 2021
The microtubule end-binding affinity of EB1 is enhanced by a dimeric organization that is susceptible to phosphorylation, Song Y, Zhang Y, Pan Y, He J, Wang Y, Chen W, Guo J, Deng H, Xue Y, Fang X, Liang X, 2020

Non-Coding Rna Intrinsically Disordered Proteins Nmr Technology Molecular Dynamics Simulation Rna-Protein Complexes 3D Structure Conformational Changes Computational Methods Structural Modeling Drug Screening

Haipeng Gong - Tsinghua University

Haipeng Gong - Tsinghua University

Zhuqing Zhang - University of Chinese Academy of Sciences

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