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Zhixin Wang
Life Science
Tsinghua University
Beijing
Language: Chinese, English
Enzymes
Catalysis
Protein Structure
Molecular Interaction
Genetic Coding
Data Analysis
Computational Modeling
Gene Expression
Algorithm Development
System Biology
Areas of Focus
- Molecular Enzymology
- Bioinformatics
Work Experience
- 1977-1981: Teaching Assistant, Department of Chemistry and Chemical Engineering, Tsinghua University
- 1988-1989: Associate Researcher, Institute of Biophysics, Chinese Academy of Sciences
- 1989-1991: Postdoctoral Fellow, Department of Chemistry, Cornell University
- 1991-1993: Research Assistant, Department of Biochemistry, North Dakota State University
- 1993-2003: Researcher, Institute of Biophysics, Chinese Academy of Sciences
- 1995-1999: Deputy Director, Institute of Biophysics, Chinese Academy of Sciences
- 1999-2003: Director, Institute of Biophysics, Chinese Academy of Sciences
- 1997-2003: Director, National Laboratory of Biomacromolecules, Beijing
- 2003-present: Professor, School of Life Sciences, Tsinghua University
Academic Background & Achievements
- 1973-1977: Bachelor in Chemistry and Chemical Engineering, Tsinghua University
- 1982-1988: PhD in Biophysics, Institute of Biophysics, Chinese Academy of Sciences
Publications
- Mechanistic studies of the autoactivation of PAK2: a two-step model of cis initiation followed by trans amplification, Wang J, Wu JW and Wang ZX, 2011
- Enzymatic activity and substrate specificity of mitogen-activated protein kinase p38alpha in different phosphorylation states, Zhang YY, Mei ZQ, Wu JW, Wang ZX, 2008
- The complete pathway for ERK2-catalyzed reaction. Evidence for an iso random Bi-Bi mechanism, Wang ZX, Wu JW, 2007
- Kinetic analysis of ligand-induced autocatalytic reactions, Liu JH and Wang ZX, 2004
- The mechanism of p21-activated protein kinase 2 autoactivation, Wu H and Wang ZX, 2003
- Cooperative autoinhibition and multi-level activation mechanisms of calcineurin, Li SJ, Wang J, Ma L, Lu C, Wang J, Wu JW, Wang ZX, 2016
- A conserved motif in JNK/p38-specific MAPK phosphatases as a determinant for JNK1 recognition and inactivation, Liu X, Zhang CS, Lu C, Lin SC, Wu JW, Wang ZX, 2016
- Structural insights into the negative regulation of BRI1 signaling by BRI1-interacting protein BKI1, Wang J, Jiang J, Wang J, Chen L, Fan SL, Wu JW, Wang X, Wang ZX, 2014
- Structural Insights into the Autoactivation Mechanism of p21-Activated Protein Kinase, Wang J, Wu JW, Wang ZX, 2011
- A distinct interaction mode revealed by the crystal structure of the Kinase p38 with the MAPK binding domain of the Phosphatase MKP5, Zhang YY, Wu JW, Wang ZX, 2011
- MAP kinase phosphatase 3-mediated crosstalk between MAP kinases ERK2 and p38α, Zhang YY, Wu JW, Wang ZX, 2011
Awards
- 1990: First Prize, Natural Science Award of the Chinese Academy of Sciences
- 1993: Second Prize, National Natural Science Award
- 1993: First Prize, Young Scientist Award of the Chinese Academy of Sciences
- 1994: Young Scientist Award of China
- 1997: Elected Member of the Chinese Academy of Sciences
- 1999: Elected Member of the Third World Academy of Sciences
