Professor | Jin Changwen | Asia Growth Partners

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Name	Jin Changwen
Contact Information	changwen (AT) pku.edu.cn
Language ability	Chinese, English
Province	Beijing

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Name

Jin Changwen

Contact Information

changwen (AT) pku.edu.cn

Language ability

Chinese, English

Province

Beijing

University/Lab Affiliation and Title	Peking University
Faculty	Life Sciences
Academic Background & Achievements	1996 - 2000 Postdoctoral Fellow: Structural Biology, University of Illinois, USA 1992 - 1994 Postdoctoral Fellow: Chemistry, Peking University 1990 - 1992 PhD in Physics, Peking University 1987 - 1990 Master of Science in Physics, Jilin University 1983 - 1987 Bachelor of Science in Physics, Jilin University
Work Experience	2001 - Present, Chief Scientist, Beijing NMR Center 2001 - Present, Professor, School of Life Sciences, Peking University 2001 - Present, Professor, College of Chemistry and Molecular Engineering, Peking University
Awards	Wang Tianjuan Spectroscopy Award, Chinese Spectroscopy Society (2008) National Science Fund for Distinguished Young Scholars (2003)

University/Lab Affiliation and Title

Peking University

Faculty

Life Sciences

Academic Background & Achievements

1996 - 2000 Postdoctoral Fellow: Structural Biology, University of Illinois, USA
1992 - 1994 Postdoctoral Fellow: Chemistry, Peking University
1990 - 1992 PhD in Physics, Peking University
1987 - 1990 Master of Science in Physics, Jilin University
1983 - 1987 Bachelor of Science in Physics, Jilin University

Work Experience

2001 - Present, Chief Scientist, Beijing NMR Center
2001 - Present, Professor, School of Life Sciences, Peking University
2001 - Present, Professor, College of Chemistry and Molecular Engineering, Peking University

Awards

Wang Tianjuan Spectroscopy Award, Chinese Spectroscopy Society (2008)
National Science Fund for Distinguished Young Scholars (2003)

Areas of Focus	Structural Biology, Protein Dynamics and Interactions, GPCR Dynamics and Function Relationship, Drug Screening
Publications	Conformational complexity and dynamics in a muscarinic receptor revealed by NMR spectroscopy, Xu J, Hu Y, Kaindl J, Risel P, Hübner H, Meada S, Niu X, Li H, Gmeiner P, Jin C, Kobilka BK, 2019 Structural basis and mechanism of the unfolding-induced activation of HdeA, a bacterial acid response chaperone, Yu XC, Hu Y, Ding J, Li H, Jin C, 2019 Intra- and inter-protein couplings of backbone motions underlie protein thiol-disulfide exchange cascade, Zhang W, Niu X, Ding J, Hu Y, Jin C, 2018 Characterizations of the interactions between Escherichia coli periplasmic chaperone HdeA and its native substrates during acid stress, Yu XC, Yang C, Ding J, Niu X, Hu Y, Jin C, 2017 Sap1 is a replication initiation factor essential for the assembly of pre-replicative complex in the fission yeast Schizosaccharomyces pombe, Guan L, He P, Yang F, Zhang Y, Hu Y, Ding J, Hua Y, Zhang Y, Ye Q, Hu J, Wang T, Jin C, Kong D, 2017 HdeB chaperone activity is coupled to its intrinsic dynamic properties, Ding J, Yang C, Niu X, Hu Y, Jin C, 2015 A Hybrid Mechanism for the Synechocystis Arsenate Reductase Revealed by Structural Snapshots during Arsenate Reduction, Hu C, Yu C, Liu Y, Hou X, Liu X, Hu Y, Jin C, 2015 Solution Structure of Yeast Rpn9: Insights for Proteasome Lid Assembly, Hu Y, Wu Y, Li Q, Zhang W, Jin C, 2015 Structural Basis for TatA Oligomerization: An NMR Study of Escherichia coli TatA Dimeric Structure, Zhang Y, Hu Y, Li H, Jin C, 2014 Chitin-induced dimerization activates a plant immune receptor, Liu T, Liu, Song C, Hu Y, Han Z, She J, Fan F, Wang J, Jin C, Chang J, Zhou J-M, Chai J, 2012 Structures of Anabaena calcium-binding protein CcbP: insights into Ca2+ signaling during heterocyst differentiation, Hu Y, Zhang X, Shi Y, Zhou Y, Zhang W, Su X-D, Xia B, Zhao J, Jin C, 2011 Solution NMR structure of the TatA component of the twin-arginine protein transport system from gram-positive bacterium Bacillus subtilis, Hu Y, Zhao E, Li H, Xia B, Jin C, 2010 Dynamics of the conformational transitions in the assembling of the Michaelis complex of a bisubstrate enzyme: a 15N relaxation study of Escherichia coli 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, Lescop E, Lu Z, Liu Q, Xu H, Li G, Xia B, Yan H, Jin C, 2009 Conformational fluctuations coupled to the thiol-disulfide transfer between thioredoxin and arsenate reductase in Bacillus subtilis, Li Y, Hu Y, Zhang X, Xu H, Lescop E, Xia B, Jin C, 2007

Areas of Focus

Structural Biology, Protein Dynamics and Interactions, GPCR Dynamics and Function Relationship, Drug Screening

Publications

Conformational complexity and dynamics in a muscarinic receptor revealed by NMR spectroscopy, Xu J, Hu Y, Kaindl J, Risel P, Hübner H, Meada S, Niu X, Li H, Gmeiner P, Jin C, Kobilka BK, 2019
Structural basis and mechanism of the unfolding-induced activation of HdeA, a bacterial acid response chaperone, Yu XC, Hu Y, Ding J, Li H, Jin C, 2019
Intra- and inter-protein couplings of backbone motions underlie protein thiol-disulfide exchange cascade, Zhang W, Niu X, Ding J, Hu Y, Jin C, 2018
Characterizations of the interactions between Escherichia coli periplasmic chaperone HdeA and its native substrates during acid stress, Yu XC, Yang C, Ding J, Niu X, Hu Y, Jin C, 2017
Sap1 is a replication initiation factor essential for the assembly of pre-replicative complex in the fission yeast Schizosaccharomyces pombe, Guan L, He P, Yang F, Zhang Y, Hu Y, Ding J, Hua Y, Zhang Y, Ye Q, Hu J, Wang T, Jin C, Kong D, 2017
HdeB chaperone activity is coupled to its intrinsic dynamic properties, Ding J, Yang C, Niu X, Hu Y, Jin C, 2015
A Hybrid Mechanism for the Synechocystis Arsenate Reductase Revealed by Structural Snapshots during Arsenate Reduction, Hu C, Yu C, Liu Y, Hou X, Liu X, Hu Y, Jin C, 2015
Solution Structure of Yeast Rpn9: Insights for Proteasome Lid Assembly, Hu Y, Wu Y, Li Q, Zhang W, Jin C, 2015
Structural Basis for TatA Oligomerization: An NMR Study of Escherichia coli TatA Dimeric Structure, Zhang Y, Hu Y, Li H, Jin C, 2014
Chitin-induced dimerization activates a plant immune receptor, Liu T, Liu, Song C, Hu Y, Han Z, She J, Fan F, Wang J, Jin C, Chang J, Zhou J-M, Chai J, 2012
Structures of Anabaena calcium-binding protein CcbP: insights into Ca2+ signaling during heterocyst differentiation, Hu Y, Zhang X, Shi Y, Zhou Y, Zhang W, Su X-D, Xia B, Zhao J, Jin C, 2011
Solution NMR structure of the TatA component of the twin-arginine protein transport system from gram-positive bacterium Bacillus subtilis, Hu Y, Zhao E, Li H, Xia B, Jin C, 2010
Dynamics of the conformational transitions in the assembling of the Michaelis complex of a bisubstrate enzyme: a 15N relaxation study of Escherichia coli 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, Lescop E, Lu Z, Liu Q, Xu H, Li G, Xia B, Yan H, Jin C, 2009
Conformational fluctuations coupled to the thiol-disulfide transfer between thioredoxin and arsenate reductase in Bacillus subtilis, Li Y, Hu Y, Zhang X, Xu H, Lescop E, Xia B, Jin C, 2007

Structural Biology Protein Dynamics Protein Interactions Gpcr Function Relationship Drug Screening Molecular Biology Biophysics Signal Transduction Membrane Proteins

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