Professor | Wen Sheng Wei | Asia Growth Partners

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Name	Wen Sheng Wei
Contact Information	wswei (AT) pku.edu.cn
Language ability	English, Chinese
Province	Beijing

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Name

Wen Sheng Wei

Contact Information

wswei (AT) pku.edu.cn

Language ability

English, Chinese

Province

Beijing

University/Lab Affiliation and Title	Peking University
Faculty	Life Sciences
Academic Background & Achievements	1999 - 2004 Postdoctoral Fellow, Genetics, Stanford University 1995 - 1999 PhD, Genetics, Michigan State University 1987 - 1991 Bachelor of Science, Biochemistry, Peking University
Work Experience	2019 - Present Professor (tenure), Peking University College of Life Sciences 2016 - Present Researcher, Beijing Future Gene Diagnosis Innovation Center (ICG) 2015 - Present Researcher, Peking-Tsinghua Center for Life Sciences (CLS) 2014 - Present Researcher, Peking University Biomedical Innovation Institute (BIOPIC) 2007 - Present Researcher, Peking University College of Life Sciences, Biochemistry and Molecular Biology 2005 - 2007 Research Associate, Stanford University School of Medicine, Department of Genetics 1999 - 2004 Postdoctoral Fellow, Stanford University School of Medicine, Department of Genetics
Awards	Beijing Advanced Worker, 2020 Changju Project Entrepreneurial Talent, 2020 Major Medical Advancements in China Award, 2019 Beijing Overseas Scholars Innovation and Entrepreneurship Special Contribution Award, 2019 BI Investigatorship Award, 2019 Peking University College of Life Sciences Unnamed Outstanding Research Award, 2019 Fourth Peking University Industry-Academia-Research Cooperation Advanced Individual Award, 2019 Beijing Science and Technology Award, 2018 China Ministry of Science and Technology Innovation Talent Promotion Plan Science and Technology Innovation Entrepreneur Talent, 2018 Peking University Teaching Excellence Award, 2018 Tan Jiazhen Life Science Innovation Award, 2016 China Patent Excellence Award, 2016 Scientific Chinese Person of the Year, 2016 Peking University Zheng Changxue Teaching Excellence Award, 2015 Bayer Investigator Award, 2014 The Roche Chinese Young Investigator Award, 2014 Peking University Dongbao Teaching Award, 2012 Most Popular Teacher Award, Peking University College of Life Sciences, 2010

University/Lab Affiliation and Title

Peking University

Faculty

Life Sciences

Academic Background & Achievements

1999 - 2004 Postdoctoral Fellow, Genetics, Stanford University
1995 - 1999 PhD, Genetics, Michigan State University
1987 - 1991 Bachelor of Science, Biochemistry, Peking University

Work Experience

2019 - Present Professor (tenure), Peking University College of Life Sciences
2016 - Present Researcher, Beijing Future Gene Diagnosis Innovation Center (ICG)
2015 - Present Researcher, Peking-Tsinghua Center for Life Sciences (CLS)
2014 - Present Researcher, Peking University Biomedical Innovation Institute (BIOPIC)
2007 - Present Researcher, Peking University College of Life Sciences, Biochemistry and Molecular Biology
2005 - 2007 Research Associate, Stanford University School of Medicine, Department of Genetics
1999 - 2004 Postdoctoral Fellow, Stanford University School of Medicine, Department of Genetics

Awards

Beijing Advanced Worker, 2020
Changju Project Entrepreneurial Talent, 2020
Major Medical Advancements in China Award, 2019
Beijing Overseas Scholars Innovation and Entrepreneurship Special Contribution Award, 2019
BI Investigatorship Award, 2019
Peking University College of Life Sciences Unnamed Outstanding Research Award, 2019
Fourth Peking University Industry-Academia-Research Cooperation Advanced Individual Award, 2019
Beijing Science and Technology Award, 2018
China Ministry of Science and Technology Innovation Talent Promotion Plan Science and Technology Innovation Entrepreneur Talent, 2018
Peking University Teaching Excellence Award, 2018
Tan Jiazhen Life Science Innovation Award, 2016
China Patent Excellence Award, 2016
Scientific Chinese Person of the Year, 2016
Peking University Zheng Changxue Teaching Excellence Award, 2015
Bayer Investigator Award, 2014
The Roche Chinese Young Investigator Award, 2014
Peking University Dongbao Teaching Award, 2012
Most Popular Teacher Award, Peking University College of Life Sciences, 2010

Areas of Focus	Gene editing technology Novel gene therapy and vaccine technology High-throughput functional genomics Molecular mechanisms of major diseases
Publications	Circular RNA Vaccines against SARS-CoV-2 and Emerging Variants, Wei W* et al., 2022 Regulatory elements can be essential for maintaining broad chromatin organization and cell viability, Wei W* et al., 2022 Gene editing and its applications in biomedicine, Wei W* et al., 2022 Engineered circular ADAR-recruiting RNAs increase the efficiency and fidelity of RNA editing in vitro and in vivo, Wei W* et al., 2022 Non-coding loci without epigenomic signals can be essential for maintaining global chromatin organization and cell viability, Wei W* et al., 2021 Sensing of cytoplasmic chromatin by cGAS activates innate immune response in SARS-CoV-2 infection, Wei W* et al., 2021 Genome-wide CRISPR activation screen identifies candidate receptors for SARS-CoV-2 entry, Wei W* et al., 2021 Low-density lipoprotein receptor-related protein 1 is a CROPs-associated receptor for Clostridioides difficile toxin B, Wei W* et al., 2021 Genome-wide interrogation of gene functions through base editor screens empowered by barcoded sgRNAs, Wei W* et al., 2021 TRIM26 is a critical host factor for HCV replication and determines host tropism, Wei W* et al., 2021 Reply to: Fitness effects of CRISPR/Cas9-targeting of long noncoding RNA genes, Wei W* et al., 2020 Structural insights into the specific recognition of 5-methylcytosine and 5-hydroxymethylcytosine by TAL effectors, Wei W* et al., 2019 PASTMUS: mapping functional elements at single amino acid resolution in human cells, Wei W* et al., 2019 Programmable RNA editing by recruiting endogenous ADAR using engineered RNAs, Wei W* et al., 2019 Human Neonatal Fc Receptor Is the Cellular Uncoating Receptor for Enterovirus B, Wei W* et al., 2019 Guide RNAs with embedded barcodes boost CRISPR-pooled screens, Wei W* et al., 2019 Genome-wide screening for functional long noncoding RNAs in human cells by Cas9 targeting of splice sites, Wei W* et al., 2018 A surrogate reporter system for multiplexable evaluation of CRISPR/Cas9 in targeted mutagenesis, Wei W* et al., 2018 Deciphering TAL effectors for 5-methylcytosine and 5-hydroxymethylcytosine recognition, Wei W* et al., 2017 Glucosyltransferase Activity of Clostridium difficile Toxin B Triggers Autophagy-mediated Cell Growth Arrest, Wei W* et al., 2017 Painting A Specific Chromosome with CRISPR/Cas9 for Live-cell Imaging, Wei W* et al., 2017 Live visualization of genomic loci with BiFC-TALE, Wei W* et al., 2017 Simultaneous generation of multi-gene knockouts in human cells, Wei W* et al., 2016 Genome-scale deletion screening of human long non-coding RNAs using a paired-guide RNA CRISPR library, Wei W* et al., 2016 High-throughput Screens in Mammalian Cells Using the CRISPR-Cas9 System, Wei W* et al., 2015 Divergent roles of BECN1 in LC3 lipidation and autophagosomal function, Wei W* et al., 2015 A Dual-Reporter System for Real-Time Monitoring and High-throughput CRISPR/Cas9 Library Screening of the Hepatitis C Virus, Wei W* et al., 2015 Chondroitin sulfate proteoglycan 4 functions as the cellular receptor for Clostridium difficile toxin B, Wei W* et al., 2015 High-throughput Screening of a CRISPR/Cas Library for Functional Genomics in Human Cells, Wei W* et al., 2014 Bidirectional effect of Wnt signaling antagonist DKK1 on the modulation of anthrax toxin uptake

Areas of Focus

Gene editing technology
Novel gene therapy and vaccine technology
High-throughput functional genomics
Molecular mechanisms of major diseases

Publications

Circular RNA Vaccines against SARS-CoV-2 and Emerging Variants, Wei W* et al., 2022
Regulatory elements can be essential for maintaining broad chromatin organization and cell viability, Wei W* et al., 2022
Gene editing and its applications in biomedicine, Wei W* et al., 2022
Engineered circular ADAR-recruiting RNAs increase the efficiency and fidelity of RNA editing in vitro and in vivo, Wei W* et al., 2022
Non-coding loci without epigenomic signals can be essential for maintaining global chromatin organization and cell viability, Wei W* et al., 2021
Sensing of cytoplasmic chromatin by cGAS activates innate immune response in SARS-CoV-2 infection, Wei W* et al., 2021
Genome-wide CRISPR activation screen identifies candidate receptors for SARS-CoV-2 entry, Wei W* et al., 2021
Low-density lipoprotein receptor-related protein 1 is a CROPs-associated receptor for Clostridioides difficile toxin B, Wei W* et al., 2021
Genome-wide interrogation of gene functions through base editor screens empowered by barcoded sgRNAs, Wei W* et al., 2021
TRIM26 is a critical host factor for HCV replication and determines host tropism, Wei W* et al., 2021
Reply to: Fitness effects of CRISPR/Cas9-targeting of long noncoding RNA genes, Wei W* et al., 2020
Structural insights into the specific recognition of 5-methylcytosine and 5-hydroxymethylcytosine by TAL effectors, Wei W* et al., 2019
PASTMUS: mapping functional elements at single amino acid resolution in human cells, Wei W* et al., 2019
Programmable RNA editing by recruiting endogenous ADAR using engineered RNAs, Wei W* et al., 2019
Human Neonatal Fc Receptor Is the Cellular Uncoating Receptor for Enterovirus B, Wei W* et al., 2019
Guide RNAs with embedded barcodes boost CRISPR-pooled screens, Wei W* et al., 2019
Genome-wide screening for functional long noncoding RNAs in human cells by Cas9 targeting of splice sites, Wei W* et al., 2018
A surrogate reporter system for multiplexable evaluation of CRISPR/Cas9 in targeted mutagenesis, Wei W* et al., 2018
Deciphering TAL effectors for 5-methylcytosine and 5-hydroxymethylcytosine recognition, Wei W* et al., 2017
Glucosyltransferase Activity of Clostridium difficile Toxin B Triggers Autophagy-mediated Cell Growth Arrest, Wei W* et al., 2017
Painting A Specific Chromosome with CRISPR/Cas9 for Live-cell Imaging, Wei W* et al., 2017
Live visualization of genomic loci with BiFC-TALE, Wei W* et al., 2017
Simultaneous generation of multi-gene knockouts in human cells, Wei W* et al., 2016
Genome-scale deletion screening of human long non-coding RNAs using a paired-guide RNA CRISPR library, Wei W* et al., 2016
High-throughput Screens in Mammalian Cells Using the CRISPR-Cas9 System, Wei W* et al., 2015
Divergent roles of BECN1 in LC3 lipidation and autophagosomal function, Wei W* et al., 2015
A Dual-Reporter System for Real-Time Monitoring and High-throughput CRISPR/Cas9 Library Screening of the Hepatitis C Virus, Wei W* et al., 2015
Chondroitin sulfate proteoglycan 4 functions as the cellular receptor for Clostridium difficile toxin B, Wei W* et al., 2015
High-throughput Screening of a CRISPR/Cas Library for Functional Genomics in Human Cells, Wei W* et al., 2014
Bidirectional effect of Wnt signaling antagonist DKK1 on the modulation of anthrax toxin uptake

Crispr Cas9 Gene Therapy Vaccines High-Throughput Genomics Disease Mechanisms Cancer Infections Molecular Biology

Lu Dongdong - Tongji University

Chunguang Wang - Tongji University

Yi Xiao - Shanghai Jiao Tong University

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