Professor | Yixuan Wang | Asia Growth Partners

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Name	Yixuan Wang
Contact Information	wangyixuan@tongji.edu.cn
Language ability	Chinese, English
Province	Shanghai

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Name

Yixuan Wang

Contact Information

wangyixuan@tongji.edu.cn

Language ability

Chinese, English

Province

Shanghai

University/Lab Affiliation and Title	Tongji University
Faculty	Life Sciences
Academic Background & Achievements	2006 Bachelor's Degree: Peking University, School of Life Sciences 2011 PhD: Tsinghua University, Peking Union Medical College, Beijing Institute of Life Sciences Recipient of the National 'Outstanding Youth Science Fund Project' Recipient of Shanghai's 'Sailing Plan' and 'Morning Light Plan' projects
Work Experience	Current - Tongji University, School of Life Science and Technology - Professor, Doctoral Supervisor Current - Affiliated Eastern Hospital - Distinguished Researcher
Awards	National 'Outstanding Youth Science Fund Project' recipient Shanghai 'Sailing Plan' project recipient Shanghai 'Morning Light Plan' project recipient

University/Lab Affiliation and Title

Tongji University

Faculty

Life Sciences

Academic Background & Achievements

2006 Bachelor's Degree: Peking University, School of Life Sciences
2011 PhD: Tsinghua University, Peking Union Medical College, Beijing Institute of Life Sciences
Recipient of the National 'Outstanding Youth Science Fund Project'
Recipient of Shanghai's 'Sailing Plan' and 'Morning Light Plan' projects

Work Experience

Current - Tongji University, School of Life Science and Technology - Professor, Doctoral Supervisor
Current - Affiliated Eastern Hospital - Distinguished Researcher

Awards

National 'Outstanding Youth Science Fund Project' recipient
Shanghai 'Sailing Plan' project recipient
Shanghai 'Morning Light Plan' project recipient

Areas of Focus	Human induced pluripotent stem cell (iPSC) technology and somatic cell reprogramming applications Molecular mechanisms of establishment and maintenance of pluripotency and totipotency in human stem cells
Publications	Cell fate roadmap of human primed-to-naive transition reveals preimplantation cell lineage signatures, Bi Y, Tu Z, Zhou J, Zhu X, Wang H, Gao S, Wang Y, 2022 Bilineage embryo-like structure from EPS cells can produce live mice with tetraploid trophectoderm, Liu K, Xu X, Bai D, Li Y, Zhang Y, Jia Y, Guo M, Han X, Liu Y, Sheng Y, Kou X, Zhao Y, Yin J, Liu S, Chen J, Wang H, Wang Y, Liu W, Gao S, 2022 Identification of ALPPL2 as a naïve pluripotent state-specific surface protein essential for human naïve pluripotency regulation, Bi Y, Tu Z, Zhang Y, Yang P, Guo M, Zhu X, Zhao C, Zhou J, Wang H, Wang Y, Gao S, 2020 Precise temporal regulation of Dux is important for embryo development, Guo M, Zhang Y, Zhou J, Bi Y, Xu J, Xu C, Kou X, Zhao Y, Li Y, Tu Z, Liu K, Lin J, Yang P, Gao S, Wang Y, 2019 Unique molecular events during reprogramming of human somatic cells to induced pluripotent stem cells (iPSCs) at naïve state, Wang Y, Zhao C, Hou Z, Yang Y, Bi Y, Wang H, Zhang Y, Gao S, 2018 Epigenetic regulation of somatic cell reprogramming, Wang Y, Bi Y, Gao S, 2017 Human Naive Embryonic Stem Cells: How Full Is the Glass?, Wang Y, Gao S, 2016 LSD1 corepressor Rcor2 orchestrates neurogenesis in the developing mouse brain, Wang Y, Wu Q, Yang P, Wang C, Liu J, Liu W, Bai Y, Yang Y, Wang H, Gao S, Wang X, 2016 Naïve iPSCs generated from β-thalassemia fibroblasts allow efficient gene correction with CRISPR/Cas9, Yang Y, Zhang X, Yi L, Hou Z, Chen J, Kou X, Zhao Y, Wang H, Sun X, Jiang C, Wang Y, Gao S, 2016 Enhanced rejuvenation in induced pluripotent stem cell-derived neurons compared with directly converted neurons from an aged mouse, Yang Y, Jiao J, Gao R, Le R, Kou X, Zhao Y, Wang H, Gao S, Wang Y, 2015 Genetic correction of β-thalassemia patient-specific iPS cells and its use in improving hemoglobin production in irradiated SCID mice, Wang Y, Zheng CG, Jiang Y, Zhang J, Chen J, Yao C, Zhao Q, Liu S, Chen K, Du J, Yang Z, Gao S, 2012 Rcor2 is a subunit of the LSD1 complex that regulates ES cell property and substitutes for Sox2 in reprogramming somatic cells to pluripotency, Yang P, Wang Y, Chen J, Li H, Kang L, Zhang Y, Chen S, Zhu B, Gao S, 2011 Generation of induced pluripotent stem cells from human beta-thalassemia fibroblast cells, Wang Y, Jiang Y, Liu S, Sun X, Gao S, 2009

Areas of Focus

Human induced pluripotent stem cell (iPSC) technology and somatic cell reprogramming applications
Molecular mechanisms of establishment and maintenance of pluripotency and totipotency in human stem cells

Publications

Cell fate roadmap of human primed-to-naive transition reveals preimplantation cell lineage signatures, Bi Y, Tu Z, Zhou J, Zhu X, Wang H, Gao S*, Wang Y*, 2022
Bilineage embryo-like structure from EPS cells can produce live mice with tetraploid trophectoderm, Liu K, Xu X, Bai D, Li Y, Zhang Y, Jia Y, Guo M, Han X, Liu Y, Sheng Y, Kou X, Zhao Y, Yin J, Liu S, Chen J, Wang H, Wang Y*, Liu W*, Gao S*, 2022
Identification of ALPPL2 as a naïve pluripotent state-specific surface protein essential for human naïve pluripotency regulation, Bi Y, Tu Z, Zhang Y, Yang P, Guo M, Zhu X, Zhao C, Zhou J, Wang H, Wang Y*, Gao S*, 2020
Precise temporal regulation of Dux is important for embryo development, Guo M, Zhang Y, Zhou J, Bi Y, Xu J, Xu C, Kou X, Zhao Y, Li Y, Tu Z, Liu K, Lin J, Yang P*, Gao S*, Wang Y*, 2019
Unique molecular events during reprogramming of human somatic cells to induced pluripotent stem cells (iPSCs) at naïve state, Wang Y*, Zhao C, Hou Z, Yang Y, Bi Y, Wang H, Zhang Y, Gao S*, 2018
Epigenetic regulation of somatic cell reprogramming, Wang Y*, Bi Y, Gao S*, 2017
Human Naive Embryonic Stem Cells: How Full Is the Glass?, Wang Y, Gao S, 2016
LSD1 corepressor Rcor2 orchestrates neurogenesis in the developing mouse brain, Wang Y, Wu Q, Yang P, Wang C, Liu J, Liu W, Bai Y, Yang Y, Wang H, Gao S, Wang X, 2016
Naïve iPSCs generated from β-thalassemia fibroblasts allow efficient gene correction with CRISPR/Cas9, Yang Y, Zhang X, Yi L, Hou Z, Chen J, Kou X, Zhao Y, Wang H, Sun X, Jiang C, Wang Y*, Gao S*, 2016
Enhanced rejuvenation in induced pluripotent stem cell-derived neurons compared with directly converted neurons from an aged mouse, Yang Y, Jiao J, Gao R, Le R, Kou X, Zhao Y, Wang H, Gao S*, Wang Y*, 2015
Genetic correction of β-thalassemia patient-specific iPS cells and its use in improving hemoglobin production in irradiated SCID mice, Wang Y, Zheng CG, Jiang Y, Zhang J, Chen J, Yao C, Zhao Q, Liu S, Chen K, Du J, Yang Z, Gao S, 2012
Rcor2 is a subunit of the LSD1 complex that regulates ES cell property and substitutes for Sox2 in reprogramming somatic cells to pluripotency, Yang P, Wang Y, Chen J, Li H, Kang L, Zhang Y, Chen S, Zhu B, Gao S, 2011
Generation of induced pluripotent stem cells from human beta-thalassemia fibroblast cells, Wang Y, Jiang Y, Liu S, Sun X, Gao S, 2009

Ipsc Somatic Cell Reprogramming Pluripotency Totipotency Stem Cells Molecular Mechanisms Gene Therapy Epigenetics Transcriptomics Surface Markers

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