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Yixuan Wang
Life Science
Tongji University
Shanghai
Language: Chinese, English
Ipsc
Somatic Cell Reprogramming
Pluripotency
Totipotency
Stem Cells
Molecular Mechanisms
Gene Therapy
Epigenetics
Transcriptomics
Surface Markers
Areas of Focus
- Human induced pluripotent stem cell (iPSC) technology and somatic cell reprogramming applications
- Molecular mechanisms of establishment and maintenance of pluripotency and totipotency in human stem cells
Work Experience
- Current - Tongji University, School of Life Science and Technology - Professor, Doctoral Supervisor
- Current - Affiliated Eastern Hospital - Distinguished Researcher
Academic Background & Achievements
- 2006 Bachelor's Degree: Peking University, School of Life Sciences
- 2011 PhD: Tsinghua University, Peking Union Medical College, Beijing Institute of Life Sciences
- Recipient of the National 'Outstanding Youth Science Fund Project'
- Recipient of Shanghai's 'Sailing Plan' and 'Morning Light Plan' projects
Publications
- Cell fate roadmap of human primed-to-naive transition reveals preimplantation cell lineage signatures, Bi Y, Tu Z, Zhou J, Zhu X, Wang H, Gao S*, Wang Y*, 2022
- Bilineage embryo-like structure from EPS cells can produce live mice with tetraploid trophectoderm, Liu K, Xu X, Bai D, Li Y, Zhang Y, Jia Y, Guo M, Han X, Liu Y, Sheng Y, Kou X, Zhao Y, Yin J, Liu S, Chen J, Wang H, Wang Y*, Liu W*, Gao S*, 2022
- Identification of ALPPL2 as a naïve pluripotent state-specific surface protein essential for human naïve pluripotency regulation, Bi Y, Tu Z, Zhang Y, Yang P, Guo M, Zhu X, Zhao C, Zhou J, Wang H, Wang Y*, Gao S*, 2020
- Precise temporal regulation of Dux is important for embryo development, Guo M, Zhang Y, Zhou J, Bi Y, Xu J, Xu C, Kou X, Zhao Y, Li Y, Tu Z, Liu K, Lin J, Yang P*, Gao S*, Wang Y*, 2019
- Unique molecular events during reprogramming of human somatic cells to induced pluripotent stem cells (iPSCs) at naïve state, Wang Y*, Zhao C, Hou Z, Yang Y, Bi Y, Wang H, Zhang Y, Gao S*, 2018
- Epigenetic regulation of somatic cell reprogramming, Wang Y*, Bi Y, Gao S*, 2017
- Human Naive Embryonic Stem Cells: How Full Is the Glass?, Wang Y, Gao S, 2016
- LSD1 corepressor Rcor2 orchestrates neurogenesis in the developing mouse brain, Wang Y, Wu Q, Yang P, Wang C, Liu J, Liu W, Bai Y, Yang Y, Wang H, Gao S, Wang X, 2016
- Naïve iPSCs generated from β-thalassemia fibroblasts allow efficient gene correction with CRISPR/Cas9, Yang Y, Zhang X, Yi L, Hou Z, Chen J, Kou X, Zhao Y, Wang H, Sun X, Jiang C, Wang Y*, Gao S*, 2016
- Enhanced rejuvenation in induced pluripotent stem cell-derived neurons compared with directly converted neurons from an aged mouse, Yang Y, Jiao J, Gao R, Le R, Kou X, Zhao Y, Wang H, Gao S*, Wang Y*, 2015
- Genetic correction of β-thalassemia patient-specific iPS cells and its use in improving hemoglobin production in irradiated SCID mice, Wang Y, Zheng CG, Jiang Y, Zhang J, Chen J, Yao C, Zhao Q, Liu S, Chen K, Du J, Yang Z, Gao S, 2012
- Rcor2 is a subunit of the LSD1 complex that regulates ES cell property and substitutes for Sox2 in reprogramming somatic cells to pluripotency, Yang P, Wang Y, Chen J, Li H, Kang L, Zhang Y, Chen S, Zhu B, Gao S, 2011
- Generation of induced pluripotent stem cells from human beta-thalassemia fibroblast cells, Wang Y, Jiang Y, Liu S, Sun X, Gao S, 2009
Awards
- National 'Outstanding Youth Science Fund Project' recipient
- Shanghai 'Sailing Plan' project recipient
- Shanghai 'Morning Light Plan' project recipient
