Professor | Rui Yue | Asia Growth Partners

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Name	Rui Yue
Contact Information	ryue@tongji.edu.cn
Language ability	English, Chinese
Province	Shanghai

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Name

Rui Yue

Contact Information

ryue@tongji.edu.cn

Language ability

English, Chinese

Province

Shanghai

University/Lab Affiliation and Title	Tongji University
Faculty	Life Sciences
Academic Background & Achievements	2005 - BEng: Zhejiang University, Chu Kochen Honors College 2011 - PhD in Science: Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences Awards: Wu Rui Scholarship, CAS President's Special Prize, CAS Outstanding PhD Thesis Award, CAS Graduate School-BHP Billiton Scholarship, Meiji Dairy Life Science Award
Work Experience	2011-2016 - Postdoctoral Researcher at UT Southwestern Medical Center, USA 2016-present - Professor at Tongji University, College of Life Science and Technology
Awards	Damon Runyon Fellowship Dean's Discretionary Award at UT Southwestern Medical Center National Overseas High-level Young Talents (2017)

University/Lab Affiliation and Title

Tongji University

Faculty

Life Sciences

Academic Background & Achievements

2005 - BEng: Zhejiang University, Chu Kochen Honors College
2011 - PhD in Science: Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences
Awards: Wu Rui Scholarship, CAS President's Special Prize, CAS Outstanding PhD Thesis Award, CAS Graduate School-BHP Billiton Scholarship, Meiji Dairy Life Science Award

Work Experience

2011-2016 - Postdoctoral Researcher at UT Southwestern Medical Center, USA
2016-present - Professor at Tongji University, College of Life Science and Technology

Awards

Damon Runyon Fellowship
Dean's Discretionary Award at UT Southwestern Medical Center
National Overseas High-level Young Talents (2017)

Areas of Focus	Identification and regulatory mechanisms of novel skeletal stem cells Development of new drugs for osteoporosis and osteoarthritis Composition and in vitro remodeling of the hematopoietic stem cell microenvironment Rejuvenation of aging hematopoietic stem cells and their clinical applications
Publications	Harnessing matrix stiffness to engineer a bone marrow niche for hematopoietic stem cell rejuvenation, Zhang, X., Cao, D., Xu, L., Xu, Y., Gao, Z., Pan, Y., Jiang, M., Wei, Y., Wang, L., Liao, Y., Wang, Q., Yang, L., Xu, X., Gao, Y., Gao, S., Wang, J., Yue, R., 2023 Inhibition of Fap Promotes Cardiac Repair by Stabilizing BNP, Sun, Y., Ma, M., Cao, D., Zheng, A., Zhang, Y., Su, Y., Wang, J., Xu, Y., Zhou, M., Tang, Y., Liu, Y., Ma, T., Fan, A., Zhang, X., Zhu, Q., Qin, J., Mo, C., Xu, Y., Zhang, L., Xu, D., Yue, R., 2023 Bone marrow-derived IGF-1 orchestrates maintenance and regeneration of the adult skeleton, Wang, J., Zhu, Q., Cao, D., Peng, Q., Zhang, X., Li, C., Zhang, C., Zhou, B. O., Yue, R., 2023 Inhibition of fibroblast activation protein ameliorates cartilage matrix degradation and osteoarthritis progression, Fan, A., Wu, G., Wang, J., Lu, L., Wang, J., Wei, H., Sun, Y., Xu, Y., Mo, C., Zhang, X., Pang, Z., Pan, Z., Wang, Y., Lu, L., Fu, G., Ma, M., Zhu, Q., Cao, D., Qin, J., Yin, F., Yue, R., 2023 Skeletal stem cells: a game changer of skeletal biology and regenerative medicine?, Zhu, Q., Ding, L., Yue, R., 2022 Single-cell transcriptomics of LepR-positive skeletal cells reveals heterogeneous stress-dependent stem and progenitor pools, Mo, C., Guo, J., Qin, J., Zhang, X., Sun, Y., Wei, H., Cao, D., Zhang, Y., Zhao, C., Xiong, Y., Zhang, Y., Sun, Y., Shen, L., Yue, R., 2022 Dissecting human embryonic skeletal stem cell ontogeny by single-cell transcriptomic and functional analyses, He, J., Yan, J., Wang, J., Zhao, L., Xin, Q., Zeng, Y., Sun, Y., Zhang, H., Bai, Z., Li, Z., Ni, Y., Gong, Y., Li, Y., He, H., Bian, Z., Lan, Y., Ma, C., Bian, L., Zhu, H., Liu, B., Yue, R., 2021 Identification of Fibroblast Activation Protein as an Osteogenic Suppressor and Anti-osteoporosis Drug Target, Wei, H., Xu, Y., Wang, Y., Xu, L., Mo, C., Li, L., Shen, B., Sun, Y., Cheng, P., Yang, L., Pang, Y., Qin, A., Cao, Y., Morrison, S. J., Yue, R., 2020 Integrin alpha11 is an Osteolectin receptor and is required for the maintenance of adult skeletal bone mass, Shen, B., Vardy, K., Hughes, P., Tasdogan, A., Zhao, Z., Yue, R., Crane, G. M., Morrison, S. J., 2019 Advice for the Next Generation: Rui Yue, Yue, R., 2019 Mapping the Mouse Cell Atlas by Microwell-Seq, Han, X., Wang, R., Zhou, Y., Fei, L., Sun, H., Lai, S., Saadatpour, A., Zhou, Z., Chen, H., Ye, F., Huang, D., Xu, Y., Huang, W., Jiang, M., Jiang, X., Mao, J., Chen, Y., Lu, C., Xie, J., Fang, Q., Wang, Y., Yue, R., Li, T., Huang, H., Orkin, S. H., Yuan, G. C., Chen, M., Guo, G., 2018 Bone marrow adipocytes promote the regeneration of stem cells and haematopoiesis by secreting SCF, Zhou, B. O., Yu, H., Yue, R., Zhao, Z., Rios, J. J., Naveiras, O., Morrison, S. J., 2017 Clec11a/osteolectin is an osteogenic growth factor that promotes the maintenance of the adult skeleton, Yue, R., Shen, B., Morrison, S. J., 2016 Leptin Receptor Promotes Adipogenesis and Reduces Osteogenesis by Regulating Mesenchymal Stromal Cells in Adult Bone Marrow, Yue, R., Zhou, B. O., Shimada, I. S., Zhao, Z., Morrison, S. J., 2016 Leptin-receptor-expressing mesenchymal stromal cells represent the main source of bone formed by adult bone marrow, Zhou, B. O., Yue, R., Murphy, M. M., Peyer, J. G., Morrison, S. J., 2014 Lysophosphatidic acid acts as a nutrient-derived developmental cue to regulate early hematopoiesis, Li, H., Yue, R., Wei, B., Gao, G., Du, J., Pei, G., 2014 Thrombin receptor regulates hematopoiesis and endothelial-to-hematopoietic transition, Yue, R., Li, H., Liu, H., Li, Y., Wei, B., Gao, G., Jin, Y., Liu, T., Wei, L., Du, J., Pei, G., 2012 Beta-arrestin1 regulates zebrafish hematopoiesis through binding to YY1 and relieving polycomb group repression, Yue, R., Kang, J., Zhao, C., Hu, W., Tang, Y., Liu, X., Pei, G., 2009

Areas of Focus

Identification and regulatory mechanisms of novel skeletal stem cells
Development of new drugs for osteoporosis and osteoarthritis
Composition and in vitro remodeling of the hematopoietic stem cell microenvironment
Rejuvenation of aging hematopoietic stem cells and their clinical applications

Publications

Harnessing matrix stiffness to engineer a bone marrow niche for hematopoietic stem cell rejuvenation, Zhang, X., Cao, D., Xu, L., Xu, Y., Gao, Z., Pan, Y., Jiang, M., Wei, Y., Wang, L., Liao, Y., Wang, Q., Yang, L., Xu, X., Gao, Y., Gao, S., Wang, J., Yue, R., 2023
Inhibition of Fap Promotes Cardiac Repair by Stabilizing BNP, Sun, Y., Ma, M., Cao, D., Zheng, A., Zhang, Y., Su, Y., Wang, J., Xu, Y., Zhou, M., Tang, Y., Liu, Y., Ma, T., Fan, A., Zhang, X., Zhu, Q., Qin, J., Mo, C., Xu, Y., Zhang, L., Xu, D., Yue, R., 2023
Bone marrow-derived IGF-1 orchestrates maintenance and regeneration of the adult skeleton, Wang, J., Zhu, Q., Cao, D., Peng, Q., Zhang, X., Li, C., Zhang, C., Zhou, B. O., Yue, R., 2023
Inhibition of fibroblast activation protein ameliorates cartilage matrix degradation and osteoarthritis progression, Fan, A., Wu, G., Wang, J., Lu, L., Wang, J., Wei, H., Sun, Y., Xu, Y., Mo, C., Zhang, X., Pang, Z., Pan, Z., Wang, Y., Lu, L., Fu, G., Ma, M., Zhu, Q., Cao, D., Qin, J., Yin, F., Yue, R., 2023
Skeletal stem cells: a game changer of skeletal biology and regenerative medicine?, Zhu, Q., Ding, L., Yue, R., 2022
Single-cell transcriptomics of LepR-positive skeletal cells reveals heterogeneous stress-dependent stem and progenitor pools, Mo, C., Guo, J., Qin, J., Zhang, X., Sun, Y., Wei, H., Cao, D., Zhang, Y., Zhao, C., Xiong, Y., Zhang, Y., Sun, Y., Shen, L., Yue, R., 2022
Dissecting human embryonic skeletal stem cell ontogeny by single-cell transcriptomic and functional analyses, He, J., Yan, J., Wang, J., Zhao, L., Xin, Q., Zeng, Y., Sun, Y., Zhang, H., Bai, Z., Li, Z., Ni, Y., Gong, Y., Li, Y., He, H., Bian, Z., Lan, Y., Ma, C., Bian, L., Zhu, H., Liu, B., Yue, R., 2021
Identification of Fibroblast Activation Protein as an Osteogenic Suppressor and Anti-osteoporosis Drug Target, Wei, H., Xu, Y., Wang, Y., Xu, L., Mo, C., Li, L., Shen, B., Sun, Y., Cheng, P., Yang, L., Pang, Y., Qin, A., Cao, Y., Morrison, S. J., Yue, R., 2020
Integrin alpha11 is an Osteolectin receptor and is required for the maintenance of adult skeletal bone mass, Shen, B., Vardy, K., Hughes, P., Tasdogan, A., Zhao, Z., Yue, R., Crane, G. M., Morrison, S. J., 2019
Advice for the Next Generation: Rui Yue, Yue, R., 2019
Mapping the Mouse Cell Atlas by Microwell-Seq, Han, X., Wang, R., Zhou, Y., Fei, L., Sun, H., Lai, S., Saadatpour, A., Zhou, Z., Chen, H., Ye, F., Huang, D., Xu, Y., Huang, W., Jiang, M., Jiang, X., Mao, J., Chen, Y., Lu, C., Xie, J., Fang, Q., Wang, Y., Yue, R., Li, T., Huang, H., Orkin, S. H., Yuan, G. C., Chen, M., Guo, G., 2018
Bone marrow adipocytes promote the regeneration of stem cells and haematopoiesis by secreting SCF, Zhou, B. O., Yu, H., Yue, R., Zhao, Z., Rios, J. J., Naveiras, O., Morrison, S. J., 2017
Clec11a/osteolectin is an osteogenic growth factor that promotes the maintenance of the adult skeleton, Yue, R., Shen, B., Morrison, S. J., 2016
Leptin Receptor Promotes Adipogenesis and Reduces Osteogenesis by Regulating Mesenchymal Stromal Cells in Adult Bone Marrow, Yue, R., Zhou, B. O., Shimada, I. S., Zhao, Z., Morrison, S. J., 2016
Leptin-receptor-expressing mesenchymal stromal cells represent the main source of bone formed by adult bone marrow, Zhou, B. O., Yue, R., Murphy, M. M., Peyer, J. G., Morrison, S. J., 2014
Lysophosphatidic acid acts as a nutrient-derived developmental cue to regulate early hematopoiesis, Li, H., Yue, R., Wei, B., Gao, G., Du, J., Pei, G., 2014
Thrombin receptor regulates hematopoiesis and endothelial-to-hematopoietic transition, Yue, R., Li, H., Liu, H., Li, Y., Wei, B., Gao, G., Jin, Y., Liu, T., Wei, L., Du, J., Pei, G., 2012
Beta-arrestin1 regulates zebrafish hematopoiesis through binding to YY1 and relieving polycomb group repression, Yue, R., Kang, J., Zhao, C., Hu, W., Tang, Y., Liu, X., Pei, G., 2009

Skeletal Stem Cells Regulatory Mechanisms Drug Development Osteoporosis Osteoarthritis Hematopoietic Stem Cells Microenvironment In Vitro Rejuvenation Clinical Applications

Rui Yue - Tongji University

Xuechun Xia - Shanghai Jiao Tong University

Xuechun Xia - Shanghai Jiao Tong University

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