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Rui Yue
Life Science
Tongji University
Shanghai
Language: English, Chinese
Skeletal Stem Cells
Regulatory Mechanisms
Drug Development
Osteoporosis
Osteoarthritis
Hematopoietic Stem Cells
Microenvironment
In Vitro
Rejuvenation
Clinical Applications
Areas of Focus
- Identification and regulatory mechanisms of novel skeletal stem cells
- Development of new drugs for osteoporosis and osteoarthritis
- Composition and in vitro remodeling of the hematopoietic stem cell microenvironment
- Rejuvenation of aging hematopoietic stem cells and their clinical applications
Work Experience
- 2011-2016 - Postdoctoral Researcher at UT Southwestern Medical Center, USA
- 2016-present - Professor at Tongji University, College of Life Science and Technology
Academic Background & Achievements
- 2005 - BEng: Zhejiang University, Chu Kochen Honors College
- 2011 - PhD in Science: Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences
- Awards: Wu Rui Scholarship, CAS President's Special Prize, CAS Outstanding PhD Thesis Award, CAS Graduate School-BHP Billiton Scholarship, Meiji Dairy Life Science Award
Publications
- Harnessing matrix stiffness to engineer a bone marrow niche for hematopoietic stem cell rejuvenation, Zhang, X., Cao, D., Xu, L., Xu, Y., Gao, Z., Pan, Y., Jiang, M., Wei, Y., Wang, L., Liao, Y., Wang, Q., Yang, L., Xu, X., Gao, Y., Gao, S., Wang, J., Yue, R., 2023
- Inhibition of Fap Promotes Cardiac Repair by Stabilizing BNP, Sun, Y., Ma, M., Cao, D., Zheng, A., Zhang, Y., Su, Y., Wang, J., Xu, Y., Zhou, M., Tang, Y., Liu, Y., Ma, T., Fan, A., Zhang, X., Zhu, Q., Qin, J., Mo, C., Xu, Y., Zhang, L., Xu, D., Yue, R., 2023
- Bone marrow-derived IGF-1 orchestrates maintenance and regeneration of the adult skeleton, Wang, J., Zhu, Q., Cao, D., Peng, Q., Zhang, X., Li, C., Zhang, C., Zhou, B. O., Yue, R., 2023
- Inhibition of fibroblast activation protein ameliorates cartilage matrix degradation and osteoarthritis progression, Fan, A., Wu, G., Wang, J., Lu, L., Wang, J., Wei, H., Sun, Y., Xu, Y., Mo, C., Zhang, X., Pang, Z., Pan, Z., Wang, Y., Lu, L., Fu, G., Ma, M., Zhu, Q., Cao, D., Qin, J., Yin, F., Yue, R., 2023
- Skeletal stem cells: a game changer of skeletal biology and regenerative medicine?, Zhu, Q., Ding, L., Yue, R., 2022
- Single-cell transcriptomics of LepR-positive skeletal cells reveals heterogeneous stress-dependent stem and progenitor pools, Mo, C., Guo, J., Qin, J., Zhang, X., Sun, Y., Wei, H., Cao, D., Zhang, Y., Zhao, C., Xiong, Y., Zhang, Y., Sun, Y., Shen, L., Yue, R., 2022
- Dissecting human embryonic skeletal stem cell ontogeny by single-cell transcriptomic and functional analyses, He, J., Yan, J., Wang, J., Zhao, L., Xin, Q., Zeng, Y., Sun, Y., Zhang, H., Bai, Z., Li, Z., Ni, Y., Gong, Y., Li, Y., He, H., Bian, Z., Lan, Y., Ma, C., Bian, L., Zhu, H., Liu, B., Yue, R., 2021
- Identification of Fibroblast Activation Protein as an Osteogenic Suppressor and Anti-osteoporosis Drug Target, Wei, H., Xu, Y., Wang, Y., Xu, L., Mo, C., Li, L., Shen, B., Sun, Y., Cheng, P., Yang, L., Pang, Y., Qin, A., Cao, Y., Morrison, S. J., Yue, R., 2020
- Integrin alpha11 is an Osteolectin receptor and is required for the maintenance of adult skeletal bone mass, Shen, B., Vardy, K., Hughes, P., Tasdogan, A., Zhao, Z., Yue, R., Crane, G. M., Morrison, S. J., 2019
- Advice for the Next Generation: Rui Yue, Yue, R., 2019
- Mapping the Mouse Cell Atlas by Microwell-Seq, Han, X., Wang, R., Zhou, Y., Fei, L., Sun, H., Lai, S., Saadatpour, A., Zhou, Z., Chen, H., Ye, F., Huang, D., Xu, Y., Huang, W., Jiang, M., Jiang, X., Mao, J., Chen, Y., Lu, C., Xie, J., Fang, Q., Wang, Y., Yue, R., Li, T., Huang, H., Orkin, S. H., Yuan, G. C., Chen, M., Guo, G., 2018
- Bone marrow adipocytes promote the regeneration of stem cells and haematopoiesis by secreting SCF, Zhou, B. O., Yu, H., Yue, R., Zhao, Z., Rios, J. J., Naveiras, O., Morrison, S. J., 2017
- Clec11a/osteolectin is an osteogenic growth factor that promotes the maintenance of the adult skeleton, Yue, R., Shen, B., Morrison, S. J., 2016
- Leptin Receptor Promotes Adipogenesis and Reduces Osteogenesis by Regulating Mesenchymal Stromal Cells in Adult Bone Marrow, Yue, R., Zhou, B. O., Shimada, I. S., Zhao, Z., Morrison, S. J., 2016
- Leptin-receptor-expressing mesenchymal stromal cells represent the main source of bone formed by adult bone marrow, Zhou, B. O., Yue, R., Murphy, M. M., Peyer, J. G., Morrison, S. J., 2014
- Lysophosphatidic acid acts as a nutrient-derived developmental cue to regulate early hematopoiesis, Li, H., Yue, R., Wei, B., Gao, G., Du, J., Pei, G., 2014
- Thrombin receptor regulates hematopoiesis and endothelial-to-hematopoietic transition, Yue, R., Li, H., Liu, H., Li, Y., Wei, B., Gao, G., Jin, Y., Liu, T., Wei, L., Du, J., Pei, G., 2012
- Beta-arrestin1 regulates zebrafish hematopoiesis through binding to YY1 and relieving polycomb group repression, Yue, R., Kang, J., Zhao, C., Hu, W., Tang, Y., Liu, X., Pei, G., 2009
Awards
- Damon Runyon Fellowship
- Dean's Discretionary Award at UT Southwestern Medical Center
- National Overseas High-level Young Talents (2017)
