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Yan Bi
Life Science
Tongji University
Shanghai
Language: Chinese, English
Pluripotency
Human
Regulation
Mechanisms
In Vitro
Embryo-Like
Models
Construction
Application
Cell Fate
Areas of Focus
- Human pluripotency establishment, maintenance, and regulation mechanisms
- In vitro construction and application of human embryo-like models
Work Experience
- 2021-2024 - Tongji University, School of Life Sciences and Technology, Postdoctoral Researcher
Academic Background & Achievements
- 2016 - BSc in Science: Zhengzhou University
- 2021 - PhD in Science: Tongji University
- Published in Nature Communications, Protein & Cell, Cell Reports
- 8 national invention patents applied, 1 granted
- Principal investigator for one national natural science foundation general and youth project
Publications
- Cell fate roadmap of human primed-to-naive transition reveals preimplantation cell lineage signatures, Bi Y et al, 2022
- Identification of ALPPL2 as a Naive Pluripotent State-Specific Surface Protein Essential for Human Naive Pluripotency Regulation, Bi Y et al, 2020
- Modeling human pregastrulation development by 3D culture of blastoids generated from primed-to-naive transitioning intermediates, Bi Y et al, 2023
- Discordance between chromatin accessibility and transcriptional activity during the human primed-to-naive pluripotency transition process, Bi Y et al, 2023
- Precise temporal regulation of Dux is important for embryo development, Bi Y et al, 2019
- Unique molecular events during reprogramming of human somatic cells to induced pluripotent stem cells (iPSCs) at naive state, Bi Y et al, 2018
Awards
- Postdoctoral 'Daily Support' from Shanghai City
