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Rui Gao
Life Science
Tongji University
Shanghai
Language: Chinese, English
Transcription Factors
Embryonic Development
Epigenetics
Germ Cells
Nuclear Transplantation
Reprogramming
Single-Cell Sequencing
Micro-Epigenomics
Gene Editing
Cell Fate
Areas of Focus
- Regulatory mechanisms of key transcription factors in early mammalian embryonic development
- Epigenetic regulation mechanisms in the development of human primordial germ cells
- Molecular mechanisms of epigenetic defects and reprogramming induced by nuclear transplantation
- Establishment and optimization of single-cell and micro-epigenomic sequencing methods
Work Experience
- 2017.6—2020.5 - Tongji University, School of Life Sciences and Technology - Postdoctoral Researcher
- 2020.5—2023.12 - Tongji University, School of Life Sciences and Technology - Assistant Professor
- 2023.12—Present - Tongji University, School of Life Sciences and Technology - Associate Professor
Academic Background & Achievements
- 2008.9—2012.7 Bachelor: Beijing Normal University, School of Life Sciences and Technology
- 2012.9—2017.6 PhD: Tsinghua University, School of Life Sciences, Beijing Institute of Life Sciences
- Published in international journals such as Cell Stem Cell, Developmental Cell, Cell Reports Medicine
- Hosted national and local scientific funding projects
Publications
- Defining a TFAP2C-centered transcription factor network during murine peri-implantation, Gao Rui et al.
- Gonadal niche safeguards human fetal germline cell development following maternal SARS-CoV-2 infection, Gao Rui et al.
- ADNP modulates SINE B2-derived CTCF-binding sites during blastocyst formation in mice, Gao Rui et al., 2024
- Resetting histone modifications during human prenatal germline development, Gao Rui et al., 2023
- Transcriptome Dynamics and Cell Dialogs Between Oocytes and Granulosa Cells in Mouse Follicle Development, Gao Rui et al., 2023
- Differential Transcriptomes and Methylomes of Trophoblast Stem Cells From Naturally-Fertilized and Somatic Cell Nuclear-Transferred Embryos, Gao Rui et al., 2021
- Esrrb plays important roles in maintaining self-renewal of trophoblast stem cells (TSCs) and reprogramming somatic cells to induced TSCs, Gao Rui et al., 2019
- Inhibition of Aberrant DNA Re-methylation Improves Post-implantation Development of Somatic Cell Nuclear Transfer Embryos, Gao Rui et al., 2018
- Direct induction of neural progenitor cells transiently passes through a partially reprogrammed state, Gao Rui et al., 2017
- Progress in understanding epigenetic remodeling during induced pluripotency, Gao Rui et al., 2015
