Professor | You Wu | Asia Growth Partners

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Name	You Wu
Contact Information	wuyou@tongji.edu.cn
Language ability	Chinese, English
Province	Shanghai

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Name

You Wu

Contact Information

wuyou@tongji.edu.cn

Language ability

Chinese, English

Province

Shanghai

University/Lab Affiliation and Title	Tongji University
Faculty	Life Sciences
Academic Background & Achievements	2011.9—2015.6 Bachelor: Tongji University, School of Life Sciences and Technology 2015.9—2020.6 PhD: Tongji University, School of Life Sciences and Technology Established microRNA methylation whole transcriptome sequencing technology
Work Experience	2020.6—2023.3 Tongji University, School of Life Sciences and Technology - Postdoctoral Researcher 2023.3—Present Tongji University, School of Life Sciences and Technology - Associate Professor
Awards	2022: National Natural Science Foundation of China (Youth) 2022: Shanghai Sailing Program 2020: Postdoctoral Research Grant

University/Lab Affiliation and Title

Tongji University

Faculty

Life Sciences

Academic Background & Achievements

2011.9—2015.6 Bachelor: Tongji University, School of Life Sciences and Technology
2015.9—2020.6 PhD: Tongji University, School of Life Sciences and Technology
Established microRNA methylation whole transcriptome sequencing technology

Work Experience

2020.6—2023.3 Tongji University, School of Life Sciences and Technology - Postdoctoral Researcher
2023.3—Present Tongji University, School of Life Sciences and Technology - Associate Professor

Awards

2022: National Natural Science Foundation of China (Youth)
2022: Shanghai Sailing Program
2020: Postdoctoral Research Grant

Areas of Focus	Embryonic development and epigenetic regulation RNA epigenetic modifications and transcriptomics Establishment and optimization of micro-cell epigenomics sequencing methods
Publications	N6-methyladenosine regulates maternal RNA maintenance in oocytes and timely RNA decay during mouse maternal-to-zygotic transition, Wu Y, Xu X, Qi M, Chen C, Li M, Yan R, Kou X, Zhao Y, Liu W, Li Y, Liu X, Zhang M, Yi C, Liu H, Xiang J, Wang H, Shen B, Gao Y, Gao S, 2022 Nuclear Exosome Targeting Complex Core Factor Zcchc8 Regulates the Degradation of LINE1 RNA in Early Embryos and Embryonic Stem Cells, Wu Y, Liu W, Chen J, Liu S, Wang M, Yang L, Chen C, Qi M, Xu Y, Qiao Z, Yan R, Kou X, Zhao Y, Shen B, Yin J, Wang H, Gao Y, Gao S, 2019 Maternal Ezh1/2 deficiency in oocyte delays H3K27me2/3 restoration and impairs epiblast development responsible for embryonic sub-lethality in mouse, Zhao Y, Bai D, Wu Y, Zhang D, Liu M, Tian Y, Lu J, Wang H, Gao S, Lu Z, 2022 Microarray Analysis Reveals Potential Biological Functions of Histone H2B Monoubiquitination, Wu Y, Chen P, Jing Y, Wang C, Men YL, Zhan W, Wang Q, Gan Z, Huang J, Xie K, Mi J, Yu C, Yu X, Chen PC, Chang JF, Cai F, Chen S, 2015 Reprogramming competence of OCT factors is determined by transactivation domains, Kim KP, Wu Y, Yoon J, Adachi K, Wu G, Velychko S, MacCarthy CM, Shin B, Röpke A, Arauzo-Bravo MJ, Stehling M, Han DW, Gao Y, Kim J, Gao S, Schöler HR, 2020 FTO mediates LINE1 m6A demethylation and chromatin regulation in mESCs and mouse development, Wei J, Yu X, Yang L, Liu X, Gao B, Huang B, Dou X, Liu J, Zou Z, Cui XL, Zhang LS, Zhao X, Liu Q, He PC, Sepich-Poore C, Zhong N, Liu W, Li Y, Kou X, Zhao Y, Wu Y, Cheng X, Chen C, An Y, Dong X, Wang H, Shu Q, Hao Z, Duan T, He YY, Li X, Gao S, Gao Y, He C, 2022 Oocyte-Specific Homeobox 1, Obox1, Facilitates Reprogramming by Promoting Mesenchymal-to-Epithelial Transition and Mitigating Cell Hyperproliferation, Wu L, Wu Y, Peng B, Hou Z, Dong Y, Chen K, Guo M, Li H, Chen X, Kou X, Zhao Y, Bi Y, Wang Y, Wang H, Le R, Kang L, Gao S, 2017 m6A facilitates hippocampus-dependent learning and memory through YTHDF1, Shi H, Zhang X, Weng YL, Lu Z, Liu Y, Lu Z, Li J, Hao P, Zhang Y, Zhang F, Wu Y, Delgado JY, Su Y, Patel MJ, Cao X, Shen B, Huang X, Ming GL, Zhuang X, Song H, He C, Zhou T, 2018 Nuclear m6A reader YTHDC1 regulates the scaffold function of LINE1 RNA in mouse ESCs and early embryos, Chen C, Liu W, Guo J, Liu Y, Liu X, Liu J, Dou X, Le R, Huang Y, Li C, Yang L, Kou X, Zhao Y, Wu Y, Chen J, Wang H, Shen B, Gao Y, Gao S, 2021 Protein Expression Landscape of Mouse Embryos during Pre-implantation Development, Gao Y, Liu X, Tang B, Li C, Kou Z, Li L, Liu W, Wu Y, Kou X, Li J, Zhao Y, Yin J, Wang H, Chen S, Liao L, Gao S, 2017 Identification of key factors conquering developmental arrest of somatic cell cloned embryos by combining embryo biopsy and single-cell sequencing, Liu W, Liu X, Wang C, Gao Y, Gao R, Kou X, Zhao Y, Li J, Wu Y, Xiu W, Wang S, Yin J, Liu W, Cai T, Wang H, Zhang Y, Gao S, 2016 SIRT6 Controls Hematopoietic Stem Cell Homeostasis through Epigenetic Regulation of Wnt Signaling, Wang H, Diao D, Shi Z, Zhu X, Gao Y, Gao S, Liu X, Wu Y, Rudolph KL, Liu G, Li T, Ju Z, 2016 Hierarchical Oct4 Binding in Concert with Primed Epigenetic Rearrangements during Somatic Cell Reprogramming, Chen J, Chen X, Li M, Liu X, Gao Y, Kou X, Zhao Y, Zheng W, Zhang X, Huo Y, Chen C, Wu Y, Wang H, Jiang C, Gao S, 2016 Mettl14-driven senescence-associated secretory phenotype facilitates somatic cell reprogramming, Xi C, Sun J, Xu X, Wu Y, Kou X, Zhao Y, Shen J, Dong Y, Chen K, Su Z, Liu D, Ye W, Liu Y, Zhang R, Xu Y, Wang H, Hao L, Wu L, Gao S, 2022

Areas of Focus

Embryonic development and epigenetic regulation
RNA epigenetic modifications and transcriptomics
Establishment and optimization of micro-cell epigenomics sequencing methods

Publications

N6-methyladenosine regulates maternal RNA maintenance in oocytes and timely RNA decay during mouse maternal-to-zygotic transition, Wu Y, Xu X, Qi M, Chen C, Li M, Yan R, Kou X, Zhao Y, Liu W, Li Y, Liu X, Zhang M, Yi C, Liu H, Xiang J, Wang H, Shen B, Gao Y, Gao S, 2022
Nuclear Exosome Targeting Complex Core Factor Zcchc8 Regulates the Degradation of LINE1 RNA in Early Embryos and Embryonic Stem Cells, Wu Y, Liu W, Chen J, Liu S, Wang M, Yang L, Chen C, Qi M, Xu Y, Qiao Z, Yan R, Kou X, Zhao Y, Shen B, Yin J, Wang H, Gao Y, Gao S, 2019
Maternal Ezh1/2 deficiency in oocyte delays H3K27me2/3 restoration and impairs epiblast development responsible for embryonic sub-lethality in mouse, Zhao Y, Bai D, Wu Y, Zhang D, Liu M, Tian Y, Lu J, Wang H, Gao S, Lu Z, 2022
Microarray Analysis Reveals Potential Biological Functions of Histone H2B Monoubiquitination, Wu Y, Chen P, Jing Y, Wang C, Men YL, Zhan W, Wang Q, Gan Z, Huang J, Xie K, Mi J, Yu C, Yu X, Chen PC, Chang JF, Cai F, Chen S, 2015
Reprogramming competence of OCT factors is determined by transactivation domains, Kim KP, Wu Y, Yoon J, Adachi K, Wu G, Velychko S, MacCarthy CM, Shin B, Röpke A, Arauzo-Bravo MJ, Stehling M, Han DW, Gao Y, Kim J, Gao S, Schöler HR, 2020
FTO mediates LINE1 m6A demethylation and chromatin regulation in mESCs and mouse development, Wei J, Yu X, Yang L, Liu X, Gao B, Huang B, Dou X, Liu J, Zou Z, Cui XL, Zhang LS, Zhao X, Liu Q, He PC, Sepich-Poore C, Zhong N, Liu W, Li Y, Kou X, Zhao Y, Wu Y, Cheng X, Chen C, An Y, Dong X, Wang H, Shu Q, Hao Z, Duan T, He YY, Li X, Gao S, Gao Y, He C, 2022
Oocyte-Specific Homeobox 1, Obox1, Facilitates Reprogramming by Promoting Mesenchymal-to-Epithelial Transition and Mitigating Cell Hyperproliferation, Wu L, Wu Y, Peng B, Hou Z, Dong Y, Chen K, Guo M, Li H, Chen X, Kou X, Zhao Y, Bi Y, Wang Y, Wang H, Le R, Kang L, Gao S, 2017
m6A facilitates hippocampus-dependent learning and memory through YTHDF1, Shi H, Zhang X, Weng YL, Lu Z, Liu Y, Lu Z, Li J, Hao P, Zhang Y, Zhang F, Wu Y, Delgado JY, Su Y, Patel MJ, Cao X, Shen B, Huang X, Ming GL, Zhuang X, Song H, He C, Zhou T, 2018
Nuclear m6A reader YTHDC1 regulates the scaffold function of LINE1 RNA in mouse ESCs and early embryos, Chen C, Liu W, Guo J, Liu Y, Liu X, Liu J, Dou X, Le R, Huang Y, Li C, Yang L, Kou X, Zhao Y, Wu Y, Chen J, Wang H, Shen B, Gao Y, Gao S, 2021
Protein Expression Landscape of Mouse Embryos during Pre-implantation Development, Gao Y, Liu X, Tang B, Li C, Kou Z, Li L, Liu W, Wu Y, Kou X, Li J, Zhao Y, Yin J, Wang H, Chen S, Liao L, Gao S, 2017
Identification of key factors conquering developmental arrest of somatic cell cloned embryos by combining embryo biopsy and single-cell sequencing, Liu W, Liu X, Wang C, Gao Y, Gao R, Kou X, Zhao Y, Li J, Wu Y, Xiu W, Wang S, Yin J, Liu W, Cai T, Wang H, Zhang Y, Gao S, 2016
SIRT6 Controls Hematopoietic Stem Cell Homeostasis through Epigenetic Regulation of Wnt Signaling, Wang H, Diao D, Shi Z, Zhu X, Gao Y, Gao S, Liu X, Wu Y, Rudolph KL, Liu G, Li T, Ju Z, 2016
Hierarchical Oct4 Binding in Concert with Primed Epigenetic Rearrangements during Somatic Cell Reprogramming, Chen J, Chen X, Li M, Liu X, Gao Y, Kou X, Zhao Y, Zheng W, Zhang X, Huo Y, Chen C, Wu Y, Wang H, Jiang C, Gao S, 2016
Mettl14-driven senescence-associated secretory phenotype facilitates somatic cell reprogramming, Xi C, Sun J, Xu X, Wu Y, Kou X, Zhao Y, Shen J, Dong Y, Chen K, Su Z, Liu D, Ye W, Liu Y, Zhang R, Xu Y, Wang H, Hao L, Wu L, Gao S, 2022

Embryonic Development Epigenetics Rna Modifications Transcriptomics Sequencing Methods Micro-Cell Gene Regulation Mammalian Embryos Stem Cells Crispr

Gang Ma - Shanghai Jiao Tong University

Yuan Kai - Central South University

Hai-Feng Wang - Tsinghua University

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