Professor | Yu Chen Xia | Asia Growth Partners

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Name	Yu Chen Xia
Contact Information	yuchenxia@whu.edu.cn
Language ability	English, Chinese, German
Province	Hubei

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Name

Yu Chen Xia

Contact Information

yuchenxia@whu.edu.cn

Language ability

English, Chinese, German

Province

Hubei

University/Lab Affiliation and Title	Wuhan University
Faculty	Medical School
Academic Background & Achievements	2008 Sep – 2013 Sep PhD: Technical University of Munich, Specialty: Medical Life Science Technology, Supervisor: Prof. Ulrike Protzer 2005 Sep – 2008 Jul Master's: Wuhan Institute of Virology, Chinese Academy of Sciences, Specialty: Biotechnology and Molecular Biology, Supervisors: Researcher Hu Zhihong, Researcher Deng Fei 2001 Sep – 2005 Jul Bachelor's: Wuhan University, College of Life Sciences, Specialty: Biotechnology
Work Experience	2018 Oct – Present: Professor, Doctoral Supervisor, National Key Laboratory of Virology, Basic Medical College, Wuhan University 2014 Oct – 2018 Sep: Postdoctoral Researcher, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, USA, Supervisor: Dr. T.Jake Liang 2013 Sep – 2014 Sep: Postdoctoral Researcher, German Research Center for Environmental Health, Supervisor: Prof. Ulrike Protzer
Awards	2021 Young Investigator Award, ISVHLD Global Hepatitis Summit 2019 Outstanding Medical Academic Young Talent, Hubei Health Commission 2019 Gilead Research Scholar, Liver Diseases Program Asia 2015 ILCA-Bayer Fellowship, awarded by International Liver Cancer Association 2015 Fellows Award for Research Excellence, NIH 2014 Visiting fellow award, Division of Intramural Research, NIH 2014 Best study of the year, German liver foundation award 2014 Best PhD thesis of the year 2013/2014 (Promotionspreis 2014), awarded by Society of Virology and German center for infection research 2013 PhD awarded with 'summa cum laude' ('with highest honor')

University/Lab Affiliation and Title

Wuhan University

Faculty

Medical School

Academic Background & Achievements

2008 Sep – 2013 Sep PhD: Technical University of Munich, Specialty: Medical Life Science Technology, Supervisor: Prof. Ulrike Protzer
2005 Sep – 2008 Jul Master's: Wuhan Institute of Virology, Chinese Academy of Sciences, Specialty: Biotechnology and Molecular Biology, Supervisors: Researcher Hu Zhihong, Researcher Deng Fei
2001 Sep – 2005 Jul Bachelor's: Wuhan University, College of Life Sciences, Specialty: Biotechnology

Work Experience

2018 Oct – Present: Professor, Doctoral Supervisor, National Key Laboratory of Virology, Basic Medical College, Wuhan University
2014 Oct – 2018 Sep: Postdoctoral Researcher, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, USA, Supervisor: Dr. T.Jake Liang
2013 Sep – 2014 Sep: Postdoctoral Researcher, German Research Center for Environmental Health, Supervisor: Prof. Ulrike Protzer

Awards

2021 Young Investigator Award, ISVHLD Global Hepatitis Summit
2019 Outstanding Medical Academic Young Talent, Hubei Health Commission
2019 Gilead Research Scholar, Liver Diseases Program Asia
2015 ILCA-Bayer Fellowship, awarded by International Liver Cancer Association
2015 Fellows Award for Research Excellence, NIH
2014 Visiting fellow award, Division of Intramural Research, NIH
2014 Best study of the year, German liver foundation award
2014 Best PhD thesis of the year 2013/2014 (Promotionspreis 2014), awarded by Society of Virology and German center for infection research
2013 PhD awarded with 'summa cum laude' ('with highest honor')

Areas of Focus	Hepatitis B virus research Novel coronavirus research Viral infection animal model construction Virus-host interaction molecular mechanisms Viral carcinogenesis and targeted therapy Novel antiviral drug screening and mechanism research Stem cell precision medicine for advanced liver disease
Publications	Hepatitis B virus hijacks TSG101 to facilitate egress via multiple vesicle bodies, Zheng Y, Wang M, Li S, Bu Y, Xu Z, Zhu G, Wu C, Zhao K, Li A, Chen Q, Wang J, Hua R, Teng Y, Zhao L, Cheng X, Xia Y, 2023 Co-delivery of Cas9 mRNA and guide RNAs edits hepatitis B virus episomal and integration DNA in mouse and tree shrew models, Yi J, Lei X, Guo F, Chen Q, Chen X, Zhao K, Zhu C, Cheng X, Lin J, Yin H, Xia Y, 2023 SARS-CoV-2 nsp13 Restricts Episomal DNA Transcription without Affecting Chromosomal DNA, Li A, Zhang B, Zhao K, Yin Z, Teng Y, Zhang L, Xu Z, Liang K, Cheng X, Xia Y, 2023 Limited disassembly of cytoplasmic hepatitis B virus nucleocapsids restricts viral infection in murine hepatic cells, Zhao K, Guo F, Wang J, Zhong Y, Yi J, Teng Y, Xu Z, Zhao L, Li A, Wang Z, Chen X, Cheng X, Xia Y, 2023 Hepatitis B Virus Core Protein Is Not Required for Covalently Closed Circular DNA Transcriptional Regulation, Zhong Y, Wu C, Xu Z, Teng Y, Zhao L, Zhao K, Wang J, Wang W, Zhan Q, Zhu C, Chen X, Liang K, Cheng X, Xia Y, 2022 A Novel Mouse Model Harboring Hepatitis B Virus Covalently Closed Circular DNA, Xu Z, Zhao L, Zhong Y, Zhu C, Zhao K, Teng Y, Cheng X, Chen Q, Xia Y, 2022 Novel function of SART1 in HNF4α transcriptional regulation contributes to its antiviral role during HBV infection, Teng Y, Xu Z, Zhao K, Zhong Y, Wang J, Zhao L, Zheng Z, Hou W, Zhu C, Chen X, Protzer U, Li Y, Xia Y, 2021 SARS-CoV-2 NSP12 Protein Is Not an Interferon-β Antagonist, Li A, Zhao K, Zhang B, Hua R, Fang Y, Jiang W, Zhang J, Hui L, Zheng Y, Li Y, Zhu C, Wang PH, Peng K, Xia Y, 2021 Clinical Characteristics of COVID-19 Patients with Hepatitis B Virus Infection - a Retrospective Study, Liu R, Zhao L, Cheng X, Huan H, Li C, Li D, Liu A, Gao G, Zhou F, Liu F, Jiang Y, Zhu C, Xia Y, 2021 Profiling serum cytokines in COVID-19 patients reveals IL-6 and IL-10 are disease severity predictors, Han H, Ma Q, Li C, Liu R, Zhao L, Wang W, Zhang P, Liu X, Gao G, Liu F, Jiang Y, Cheng X, Zhu C, Xia Y*, 2020 Development of Direct-acting Antiviral and Host-targeting Agents for Treatment of HBV Infection, Xia Y, Liang TJ, 2019 Human stem cell-derived hepatocytes as a model for hepatitis B virus infection, spreading and virus-host interactions, Xia Y, Carpentier A, Cheng X, Block PD, Zhao Y, Zhang Z, Protzer U, Liang TJ, 2017 Interferon-γ and Tumor Necrosis Factor-α Produced by T Cells Reduce the HBV Persistence Form, cccDNA, Without Cytolysis, Xia Y, Stadler D, Lucifora J, Reisinger F, Webb D, Hösel M, Michler T, Wisskirchen K, Cheng X, Zhang K, Chou WM, Wettengel JM, Malo A, Bohne F, Hoffmann D, Eyer F, Thimme R, Falk CS, Thasler WE, Heikenwalder M, Protzer U, 2016 Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA, Lucifora J, Xia Y, Reisinger F, Zhang K, Stadler D, Cheng X, Sprinzl MF, Koppensteiner H, Makowska Z, Volz T, Remouchamps C, Chou WM, Thasler WE, Hüser N, Durantel D, Liang TJ, Münk C, Heim MH, Browning JL, Dejardin E, Dandri M, Schindler M, Heikenwalder M, Protzer U, 2014

Areas of Focus

Hepatitis B virus research
Novel coronavirus research
Viral infection animal model construction
Virus-host interaction molecular mechanisms
Viral carcinogenesis and targeted therapy
Novel antiviral drug screening and mechanism research
Stem cell precision medicine for advanced liver disease

Publications

Hepatitis B virus hijacks TSG101 to facilitate egress via multiple vesicle bodies, Zheng Y, Wang M, Li S, Bu Y, Xu Z, Zhu G, Wu C, Zhao K, Li A, Chen Q, Wang J, Hua R, Teng Y, Zhao L, Cheng X, Xia Y*, 2023
Co-delivery of Cas9 mRNA and guide RNAs edits hepatitis B virus episomal and integration DNA in mouse and tree shrew models, Yi J, Lei X, Guo F, Chen Q, Chen X, Zhao K, Zhu C, Cheng X, Lin J*, Yin H*, Xia Y*, 2023
SARS-CoV-2 nsp13 Restricts Episomal DNA Transcription without Affecting Chromosomal DNA, Li A, Zhang B, Zhao K, Yin Z, Teng Y, Zhang L, Xu Z, Liang K, Cheng X*, Xia Y*, 2023
Limited disassembly of cytoplasmic hepatitis B virus nucleocapsids restricts viral infection in murine hepatic cells, Zhao K, Guo F, Wang J, Zhong Y, Yi J, Teng Y, Xu Z, Zhao L, Li A, Wang Z, Chen X, Cheng X, Xia Y*, 2023
Hepatitis B Virus Core Protein Is Not Required for Covalently Closed Circular DNA Transcriptional Regulation, Zhong Y, Wu C, Xu Z, Teng Y, Zhao L, Zhao K, Wang J, Wang W, Zhan Q, Zhu C, Chen X, Liang K, Cheng X, Xia Y*, 2022
A Novel Mouse Model Harboring Hepatitis B Virus Covalently Closed Circular DNA, Xu Z, Zhao L, Zhong Y, Zhu C, Zhao K, Teng Y, Cheng X, Chen Q, Xia Y*, 2022
Novel function of SART1 in HNF4α transcriptional regulation contributes to its antiviral role during HBV infection, Teng Y, Xu Z, Zhao K, Zhong Y, Wang J, Zhao L, Zheng Z, Hou W, Zhu C, Chen X, Protzer U, Li Y*, Xia Y*, 2021
SARS-CoV-2 NSP12 Protein Is Not an Interferon-β Antagonist, Li A, Zhao K, Zhang B, Hua R, Fang Y, Jiang W, Zhang J, Hui L, Zheng Y, Li Y, Zhu C, Wang PH, Peng K, Xia Y*, 2021
Clinical Characteristics of COVID-19 Patients with Hepatitis B Virus Infection - a Retrospective Study, Liu R, Zhao L, Cheng X, Huan H, Li C, Li D, Liu A, Gao G, Zhou F, Liu F, Jiang Y*, Zhu C*, Xia Y*, 2021
Profiling serum cytokines in COVID-19 patients reveals IL-6 and IL-10 are disease severity predictors, Han H, Ma Q, Li C, Liu R, Zhao L, Wang W, Zhang P, Liu X, Gao G, Liu F, Jiang Y, Cheng X, Zhu C*, Xia Y*, 2020
Development of Direct-acting Antiviral and Host-targeting Agents for Treatment of HBV Infection, Xia Y, Liang TJ, 2019
Human stem cell-derived hepatocytes as a model for hepatitis B virus infection, spreading and virus-host interactions, Xia Y, Carpentier A, Cheng X, Block PD, Zhao Y, Zhang Z, Protzer U, Liang TJ, 2017
Interferon-γ and Tumor Necrosis Factor-α Produced by T Cells Reduce the HBV Persistence Form, cccDNA, Without Cytolysis, Xia Y, Stadler D, Lucifora J, Reisinger F, Webb D, Hösel M, Michler T, Wisskirchen K, Cheng X, Zhang K, Chou WM, Wettengel JM, Malo A, Bohne F, Hoffmann D, Eyer F, Thimme R, Falk CS, Thasler WE, Heikenwalder M, Protzer U, 2016
Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA, Lucifora J, Xia Y, Reisinger F, Zhang K, Stadler D, Cheng X, Sprinzl MF, Koppensteiner H, Makowska Z, Volz T, Remouchamps C, Chou WM, Thasler WE, Hüser N, Durantel D, Liang TJ, Münk C, Heim MH, Browning JL, Dejardin E, Dandri M, Schindler M, Heikenwalder M, Protzer U, 2014

Hepatitis B Coronavirus Animal Models Molecular Mechanisms Carcinogenesis Targeted Therapy Antiviral Drugs Drug Screening Stem Cells Liver Disease

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