Professor | Wenqing Chen | Asia Growth Partners

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Name	Wenqing Chen
Contact Information	wqchen@whu.edu.cn
Language ability	English, Chinese
Province	Hubei

Upload Avatar (500 x 500)

Name

Wenqing Chen

Contact Information

wqchen@whu.edu.cn

Language ability

English, Chinese

Province

Hubei

University/Lab Affiliation and Title	Wuhan University
Faculty	Medical School
Academic Background & Achievements	2005-2009: PhD, Shanghai Jiao Tong University Postdoctoral Researcher at Microbial Metabolism National Key Laboratory, Shanghai Jiao Tong University (2009-2011) Postdoctoral Researcher at UCLA, USA (2013-2014, CSC Scholarship)
Work Experience	2011-present: Associate Professor to Professor, Wuhan University School of Pharmaceutical Sciences
Awards	First Prize in Synthetic Biology Competition (Highest Award), Best Team Award, Best Defense Award, and Gold Award Hubei Province Top Young Medical Talent (Mid-term Excellent Assessment) Wuhan University 2017-2018 Undergraduate Excellent Teaching Performance Award (Professional Theoretical Courses) Wuhan University Excellent Bachelor's Thesis Advisor (2017 and 2018) Wuhan University Zhu Yubi Medical Award Wuhan University Outstanding Teaching Research Paper First Prize Wuhan City Youth Science and Technology Morning Light Plan World University Student Pharmaceutical Forum Innovation Achievement Second Prize (Advisor) Wuhan University Luojia Young Scholar Shanghai Jiao Tong University Zhao Zhumulan Scholarship Shanghai Jiao Tong University Outstanding Doctoral Dissertation Award Fund

University/Lab Affiliation and Title

Wuhan University

Faculty

Medical School

Academic Background & Achievements

2005-2009: PhD, Shanghai Jiao Tong University
Postdoctoral Researcher at Microbial Metabolism National Key Laboratory, Shanghai Jiao Tong University (2009-2011)
Postdoctoral Researcher at UCLA, USA (2013-2014, CSC Scholarship)

Work Experience

2011-present: Associate Professor to Professor, Wuhan University School of Pharmaceutical Sciences

Awards

First Prize in Synthetic Biology Competition (Highest Award), Best Team Award, Best Defense Award, and Gold Award
Hubei Province Top Young Medical Talent (Mid-term Excellent Assessment)
Wuhan University 2017-2018 Undergraduate Excellent Teaching Performance Award (Professional Theoretical Courses)
Wuhan University Excellent Bachelor's Thesis Advisor (2017 and 2018)
Wuhan University Zhu Yubi Medical Award
Wuhan University Outstanding Teaching Research Paper First Prize
Wuhan City Youth Science and Technology Morning Light Plan
World University Student Pharmaceutical Forum Innovation Achievement Second Prize (Advisor)
Wuhan University Luojia Young Scholar
Shanghai Jiao Tong University Zhao Zhumulan Scholarship
Shanghai Jiao Tong University Outstanding Doctoral Dissertation Award Fund

Areas of Focus	Biosynthesis of important nucleoside functional molecules (focusing on natural drugs) Biomanufacture of important nucleoside functional molecules Physiological functions and metabolism of important nucleoside functional molecules
Publications	Structural insight into the catalytic mechanism of non-heme iron halogenase AdaV in 2′-chloropentostatin biosynthesis, Zhai G, Gong R, Lin Y, Zhang M, Li J, Deng Z, Sun J, Chen W, Zhang Z, 2022 Biosynthesis of C-nucleoside antibiotics in actinobacteria: recent advances and future developments, Zhang M, Kong L, Gong R, Iorio M, Donadio S, Deng Z, Sosio M, Chen W, 2022 Efficient biosynthesis of nucleoside cytokinin angustmycin A containing an unusual sugar system, Yu L, Zhou W, She Y, Ma H, Cai Y-S, Jiang M, Deng Z, Price NPJ, Chen W, 2021 Harnessing synthetic biology-based strategies for engineered biosynthesis of nucleoside natural products in actinobacteria, Gong R, Yu L, Qin Y, Price NPJ, He X, Deng Z, Chen W, 2021 Comparative investigation into formycin A and pyrazofurin A biosynthesis reveals branch pathways for the construction of C-nucleoside scaffolds, Zhang M, Zhang P, Xu G, Zhou W, Gao Y, Gong R, Cai Y-S, Cong H, Deng Z, Price NPJ, Mao X, Chen W, 2020 Divergent biosynthesis of C-nucleoside minimycin and indigoidine in bacteria, Kong L, Xu G, Liu X, Wang J, Tang Z, Cai Y-S, Shen K, Tao W, Zheng Y, Deng Z, Price NPJ, Chen W, 2019 Coordinated biosynthesis of the purine nucleoside antibiotics aristeromycin and coformycin in Actinomycetes, Xu G, Kong L, Xu L, Gao Y, Jiang M, Cai Y-S, Hong K, Hu Y, Liu P, Deng Z, Price NPJ, Chen W, 2018 Discovery and characterization of the tubercidin biosynthetic pathway from Streptomyces tubercidicus NBRC 13090, Liu Y, Gong R, Liu X, Zhang P, Zhang Q, Cai Y-S, Deng Z, Winkler M, Wu J, Chen W, 2018 An ATP-dependent ligase with substrate flexibility involved in assembly of the peptidyl nucleoside antibiotic polyoxin, Gong R, Qi J, Wu P, Cai Y-S, Ma H, Liu Y, Duan H, Wang M, Deng Z, Price NPJ, Chen W, 2018 Biosynthesis of 2′-chloropentostatin and 2′-amino-2′-deoxyadenosine highlights a single gene cluster responsible for two individual pathways in Actinomadura sp. ATCC 39365, Gao Y, Xu G, Wu P, Liu J, Deng Z, Chen W, 2017 An unusual protector-protégé strategy for the biosynthesis of purine nucleoside antibiotics, Wu P, Wan D, Xu G, Wang G, Ma H, Wang T, Gao Y, Qi J, Chen X, Zhu J, Li Y-Q, Deng Z, Chen W, 2017 Construction of the octosyl acid backbone catalyzed by a radical S-adenosylmethionine enzyme and a phosphatase in the biosynthesis of high-carbon sugar nucleoside antibiotics, He N, Wu P, Lei Y, Xu B, Zhu X, Xu G, Gao Y, Qi J, Deng Z, Tang G, Chen W, Xiao Y, 2017 Characterization of the aurantimycin biosynthetic gene cluster and enhancing its production by manipulating two pathway-specific activators in Streptomyces aurantiacus JA 4570, Zhao H, Wang L, Wan D, Qi J, Gong R, Deng Z, Chen W, 2016 Deciphering carbamoylpolyoxamic acid biosynthesis reveals unusual acetylation cycle associated with tandem reduction and sequential hydroxylation, Qi J, Wan D, Ma H, Liu Y, Gong R, Qu X, Sun Y, Deng Z, Chen W, 2016 An unusual UMP C-5 methylase in nucleoside antibiotic polyoxin biosynthesis, Chen W, Li Y, Li J, Wu L, Li Y, Wang R, Deng Z, Zhou J, 2016 Natural and engineered biosynthesis of nucleoside antibiotics in Actinomycetes, Chen W, Dai D, Wang C, Huang T, Zhai L, Deng Z, 2013 Identification of Mur34 as the novel negative regulator responsible for the biosynthesis of muraymycin in Streptomyces sp. NRRL 30471, Xu D, Liu G, Cheng L, Lu X, Chen W, Deng Z, 2013 Engineering of an industrial polyoxin producer for the rational production of hybrid peptidyl nucleoside antibiotics, Zhai L, Lin S, Qu D, Hong X, Bai L, Chen W, Deng Z, 2012 Genome sequences of three tunicamycin-producing Streptomyces strains; S. chartreusis NRRL 12338, S. chartreusis NRRL 3882, and S. lysosuperificus ATCC 31396, Doroghazi J, Ju K, Brown D, Labeda D, Deng Z, Metcalf W, Chen W, Price NPJ, 2011 Identification of the gene cluster involved in muraymycin biosynthesis from Streptomyces sp. NRRL 30471, Cheng L, Chen W, Zhai L, Xu D, Huang T, Lin S, Zhou X, Deng Z, 2011 Characterization of the tunicamycin gene cluster unveiling unique steps involved in its biosynthesis, Chen W, Qu D, Zhai L, Tao M, Wang Y, Lin S, Price NPJ, Deng Z, 2010 Characterization of the polyoxin biosynthetic gene cluster from Streptomyces cacaoi and engineered production of polyoxin H, Chen W, Huang T, He X, Meng Q, You D, Bai L, Li J, Wu M, Li R, Xie Z, Zhou H, Zhou X, Tan H, Deng Z

Areas of Focus

Biosynthesis of important nucleoside functional molecules (focusing on natural drugs)
Biomanufacture of important nucleoside functional molecules
Physiological functions and metabolism of important nucleoside functional molecules

Publications

Structural insight into the catalytic mechanism of non-heme iron halogenase AdaV in 2′-chloropentostatin biosynthesis, Zhai G, Gong R, Lin Y, Zhang M, Li J, Deng Z, Sun J, Chen W, Zhang Z, 2022
Biosynthesis of C-nucleoside antibiotics in actinobacteria: recent advances and future developments, Zhang M, Kong L, Gong R, Iorio M, Donadio S, Deng Z, Sosio M, Chen W, 2022
Efficient biosynthesis of nucleoside cytokinin angustmycin A containing an unusual sugar system, Yu L, Zhou W, She Y, Ma H, Cai Y-S, Jiang M, Deng Z, Price NPJ, Chen W, 2021
Harnessing synthetic biology-based strategies for engineered biosynthesis of nucleoside natural products in actinobacteria, Gong R, Yu L, Qin Y, Price NPJ, He X, Deng Z, Chen W, 2021
Comparative investigation into formycin A and pyrazofurin A biosynthesis reveals branch pathways for the construction of C-nucleoside scaffolds, Zhang M, Zhang P, Xu G, Zhou W, Gao Y, Gong R, Cai Y-S, Cong H, Deng Z, Price NPJ, Mao X, Chen W, 2020
Divergent biosynthesis of C-nucleoside minimycin and indigoidine in bacteria, Kong L, Xu G, Liu X, Wang J, Tang Z, Cai Y-S, Shen K, Tao W, Zheng Y, Deng Z, Price NPJ, Chen W, 2019
Coordinated biosynthesis of the purine nucleoside antibiotics aristeromycin and coformycin in Actinomycetes, Xu G, Kong L, Xu L, Gao Y, Jiang M, Cai Y-S, Hong K, Hu Y, Liu P, Deng Z, Price NPJ, Chen W, 2018
Discovery and characterization of the tubercidin biosynthetic pathway from Streptomyces tubercidicus NBRC 13090, Liu Y, Gong R, Liu X, Zhang P, Zhang Q, Cai Y-S, Deng Z, Winkler M, Wu J, Chen W, 2018
An ATP-dependent ligase with substrate flexibility involved in assembly of the peptidyl nucleoside antibiotic polyoxin, Gong R, Qi J, Wu P, Cai Y-S, Ma H, Liu Y, Duan H, Wang M, Deng Z, Price NPJ, Chen W, 2018
Biosynthesis of 2′-chloropentostatin and 2′-amino-2′-deoxyadenosine highlights a single gene cluster responsible for two individual pathways in Actinomadura sp. ATCC 39365, Gao Y, Xu G, Wu P, Liu J, Deng Z, Chen W, 2017
An unusual protector-protégé strategy for the biosynthesis of purine nucleoside antibiotics, Wu P, Wan D, Xu G, Wang G, Ma H, Wang T, Gao Y, Qi J, Chen X, Zhu J, Li Y-Q, Deng Z, Chen W, 2017
Construction of the octosyl acid backbone catalyzed by a radical S-adenosylmethionine enzyme and a phosphatase in the biosynthesis of high-carbon sugar nucleoside antibiotics, He N, Wu P, Lei Y, Xu B, Zhu X, Xu G, Gao Y, Qi J, Deng Z, Tang G, Chen W, Xiao Y, 2017
Characterization of the aurantimycin biosynthetic gene cluster and enhancing its production by manipulating two pathway-specific activators in Streptomyces aurantiacus JA 4570, Zhao H, Wang L, Wan D, Qi J, Gong R, Deng Z, Chen W, 2016
Deciphering carbamoylpolyoxamic acid biosynthesis reveals unusual acetylation cycle associated with tandem reduction and sequential hydroxylation, Qi J, Wan D, Ma H, Liu Y, Gong R, Qu X, Sun Y, Deng Z, Chen W, 2016
An unusual UMP C-5 methylase in nucleoside antibiotic polyoxin biosynthesis, Chen W, Li Y, Li J, Wu L, Li Y, Wang R, Deng Z, Zhou J, 2016
Natural and engineered biosynthesis of nucleoside antibiotics in Actinomycetes, Chen W, Dai D, Wang C, Huang T, Zhai L, Deng Z, 2013
Identification of Mur34 as the novel negative regulator responsible for the biosynthesis of muraymycin in Streptomyces sp. NRRL 30471, Xu D, Liu G, Cheng L, Lu X, Chen W, Deng Z, 2013
Engineering of an industrial polyoxin producer for the rational production of hybrid peptidyl nucleoside antibiotics, Zhai L, Lin S, Qu D, Hong X, Bai L, Chen W, Deng Z, 2012
Genome sequences of three tunicamycin-producing Streptomyces strains; S. chartreusis NRRL 12338, S. chartreusis NRRL 3882, and S. lysosuperificus ATCC 31396, Doroghazi J, Ju K, Brown D, Labeda D, Deng Z, Metcalf W, Chen W, Price NPJ, 2011
Identification of the gene cluster involved in muraymycin biosynthesis from Streptomyces sp. NRRL 30471, Cheng L, Chen W, Zhai L, Xu D, Huang T, Lin S, Zhou X, Deng Z, 2011
Characterization of the tunicamycin gene cluster unveiling unique steps involved in its biosynthesis, Chen W, Qu D, Zhai L, Tao M, Wang Y, Lin S, Price NPJ, Deng Z, 2010
Characterization of the polyoxin biosynthetic gene cluster from Streptomyces cacaoi and engineered production of polyoxin H, Chen W, Huang T, He X, Meng Q, You D, Bai L, Li J, Wu M, Li R, Xie Z, Zhou H, Zhou X, Tan H, Deng Z

Biosynthesis Nucleosides Natural Drugs Gene Resources Enzymatic Mechanisms Green Biomanufacturing Synthetic Pathways Drug Intermediates Chemical Products Food Additives Biomanufacture Health Products Breakthrough Technologies Synthetic Biology Industrial Production Pharmaceutical Cooperation Metabolic Networks Drug Synthesis Pathways Quality Improvement Yield Enhancement Physiological Functions Metabolism Health Science Multidisciplinary Cooperation Molecular Level Metabolic Mechanisms Clinical Drugs Antiviral Anticancer Clinical Treatment

Weiwei Luo - University of Chinese Academy of Sciences

Jie Li - Nanjing University

Zixin Deng - Wuhan University

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