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Wenqing Chen
Medical School
Wuhan University
Hubei
Language: English, Chinese
Biosynthesis
Nucleosides
Natural Drugs
Gene Resources
Enzymatic Mechanisms
Green Biomanufacturing
Synthetic Pathways
Drug Intermediates
Chemical Products
Food Additives
Biomanufacture
Health Products
Breakthrough Technologies
Synthetic Biology
Industrial Production
Pharmaceutical Cooperation
Metabolic Networks
Drug Synthesis Pathways
Quality Improvement
Yield Enhancement
Physiological Functions
Metabolism
Health Science
Multidisciplinary Cooperation
Molecular Level
Metabolic Mechanisms
Clinical Drugs
Antiviral
Anticancer
Clinical Treatment
Areas of Focus
- Biosynthesis of important nucleoside functional molecules (focusing on natural drugs)
- Biomanufacture of important nucleoside functional molecules
- Physiological functions and metabolism of important nucleoside functional molecules
Work Experience
- 2011-present: Associate Professor to Professor, Wuhan University School of Pharmaceutical Sciences
Academic Background & Achievements
- 2005-2009: PhD, Shanghai Jiao Tong University
- Postdoctoral Researcher at Microbial Metabolism National Key Laboratory, Shanghai Jiao Tong University (2009-2011)
- Postdoctoral Researcher at UCLA, USA (2013-2014, CSC Scholarship)
Publications
- Structural insight into the catalytic mechanism of non-heme iron halogenase AdaV in 2′-chloropentostatin biosynthesis, Zhai G, Gong R, Lin Y, Zhang M, Li J, Deng Z, Sun J, Chen W, Zhang Z, 2022
- Biosynthesis of C-nucleoside antibiotics in actinobacteria: recent advances and future developments, Zhang M, Kong L, Gong R, Iorio M, Donadio S, Deng Z, Sosio M, Chen W, 2022
- Efficient biosynthesis of nucleoside cytokinin angustmycin A containing an unusual sugar system, Yu L, Zhou W, She Y, Ma H, Cai Y-S, Jiang M, Deng Z, Price NPJ, Chen W, 2021
- Harnessing synthetic biology-based strategies for engineered biosynthesis of nucleoside natural products in actinobacteria, Gong R, Yu L, Qin Y, Price NPJ, He X, Deng Z, Chen W, 2021
- Comparative investigation into formycin A and pyrazofurin A biosynthesis reveals branch pathways for the construction of C-nucleoside scaffolds, Zhang M, Zhang P, Xu G, Zhou W, Gao Y, Gong R, Cai Y-S, Cong H, Deng Z, Price NPJ, Mao X, Chen W, 2020
- Divergent biosynthesis of C-nucleoside minimycin and indigoidine in bacteria, Kong L, Xu G, Liu X, Wang J, Tang Z, Cai Y-S, Shen K, Tao W, Zheng Y, Deng Z, Price NPJ, Chen W, 2019
- Coordinated biosynthesis of the purine nucleoside antibiotics aristeromycin and coformycin in Actinomycetes, Xu G, Kong L, Xu L, Gao Y, Jiang M, Cai Y-S, Hong K, Hu Y, Liu P, Deng Z, Price NPJ, Chen W, 2018
- Discovery and characterization of the tubercidin biosynthetic pathway from Streptomyces tubercidicus NBRC 13090, Liu Y, Gong R, Liu X, Zhang P, Zhang Q, Cai Y-S, Deng Z, Winkler M, Wu J, Chen W, 2018
- An ATP-dependent ligase with substrate flexibility involved in assembly of the peptidyl nucleoside antibiotic polyoxin, Gong R, Qi J, Wu P, Cai Y-S, Ma H, Liu Y, Duan H, Wang M, Deng Z, Price NPJ, Chen W, 2018
- Biosynthesis of 2′-chloropentostatin and 2′-amino-2′-deoxyadenosine highlights a single gene cluster responsible for two individual pathways in Actinomadura sp. ATCC 39365, Gao Y, Xu G, Wu P, Liu J, Deng Z, Chen W, 2017
- An unusual protector-protégé strategy for the biosynthesis of purine nucleoside antibiotics, Wu P, Wan D, Xu G, Wang G, Ma H, Wang T, Gao Y, Qi J, Chen X, Zhu J, Li Y-Q, Deng Z, Chen W, 2017
- Construction of the octosyl acid backbone catalyzed by a radical S-adenosylmethionine enzyme and a phosphatase in the biosynthesis of high-carbon sugar nucleoside antibiotics, He N, Wu P, Lei Y, Xu B, Zhu X, Xu G, Gao Y, Qi J, Deng Z, Tang G, Chen W, Xiao Y, 2017
- Characterization of the aurantimycin biosynthetic gene cluster and enhancing its production by manipulating two pathway-specific activators in Streptomyces aurantiacus JA 4570, Zhao H, Wang L, Wan D, Qi J, Gong R, Deng Z, Chen W, 2016
- Deciphering carbamoylpolyoxamic acid biosynthesis reveals unusual acetylation cycle associated with tandem reduction and sequential hydroxylation, Qi J, Wan D, Ma H, Liu Y, Gong R, Qu X, Sun Y, Deng Z, Chen W, 2016
- An unusual UMP C-5 methylase in nucleoside antibiotic polyoxin biosynthesis, Chen W, Li Y, Li J, Wu L, Li Y, Wang R, Deng Z, Zhou J, 2016
- Natural and engineered biosynthesis of nucleoside antibiotics in Actinomycetes, Chen W, Dai D, Wang C, Huang T, Zhai L, Deng Z, 2013
- Identification of Mur34 as the novel negative regulator responsible for the biosynthesis of muraymycin in Streptomyces sp. NRRL 30471, Xu D, Liu G, Cheng L, Lu X, Chen W, Deng Z, 2013
- Engineering of an industrial polyoxin producer for the rational production of hybrid peptidyl nucleoside antibiotics, Zhai L, Lin S, Qu D, Hong X, Bai L, Chen W, Deng Z, 2012
- Genome sequences of three tunicamycin-producing Streptomyces strains; S. chartreusis NRRL 12338, S. chartreusis NRRL 3882, and S. lysosuperificus ATCC 31396, Doroghazi J, Ju K, Brown D, Labeda D, Deng Z, Metcalf W, Chen W, Price NPJ, 2011
- Identification of the gene cluster involved in muraymycin biosynthesis from Streptomyces sp. NRRL 30471, Cheng L, Chen W, Zhai L, Xu D, Huang T, Lin S, Zhou X, Deng Z, 2011
- Characterization of the tunicamycin gene cluster unveiling unique steps involved in its biosynthesis, Chen W, Qu D, Zhai L, Tao M, Wang Y, Lin S, Price NPJ, Deng Z, 2010
- Characterization of the polyoxin biosynthetic gene cluster from Streptomyces cacaoi and engineered production of polyoxin H, Chen W, Huang T, He X, Meng Q, You D, Bai L, Li J, Wu M, Li R, Xie Z, Zhou H, Zhou X, Tan H, Deng Z
Awards
- First Prize in Synthetic Biology Competition (Highest Award), Best Team Award, Best Defense Award, and Gold Award
- Hubei Province Top Young Medical Talent (Mid-term Excellent Assessment)
- Wuhan University 2017-2018 Undergraduate Excellent Teaching Performance Award (Professional Theoretical Courses)
- Wuhan University Excellent Bachelor's Thesis Advisor (2017 and 2018)
- Wuhan University Zhu Yubi Medical Award
- Wuhan University Outstanding Teaching Research Paper First Prize
- Wuhan City Youth Science and Technology Morning Light Plan
- World University Student Pharmaceutical Forum Innovation Achievement Second Prize (Advisor)
- Wuhan University Luojia Young Scholar
- Shanghai Jiao Tong University Zhao Zhumulan Scholarship
- Shanghai Jiao Tong University Outstanding Doctoral Dissertation Award Fund
