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Yi Yu
Medical School
Wuhan University
Hubei
Language: Chinese, English
Chemical Biology
Synthetic Biology
Medicinal Plants
Natural Products
Drug Development
Metabolic Engineering
Gene Engineering
Biosynthesis
Microbial Sources
Herbal Medicine
Areas of Focus
- Chemical Biology and Synthetic Biology of Medicinal Plant Natural Products
Work Experience
- 2007.7 – 2009.6: Lecturer, Department of Biological Engineering, School of Life Sciences and Technology, Shanghai Jiao Tong University
- 2007.3 – 2009.6: Collaborative Research, Shanghai Institute of Organic Chemistry
- 2009.7 – 2010.6: Lecturer, College of Life Science and Technology, Huazhong Agricultural University
- 2012.8 – 2013.8: Visiting Scholar, Washington University in Saint Louis, USA
- 2010.7 – Present: Professor, Doctoral Supervisor, Wuhan University School of Pharmaceutical Sciences
- 2018.1 – 2018.12: Senior Visiting Scholar, University of Oxford, UK
Academic Background & Achievements
- 1996.9 – 2002.6: Bachelor and Master of Biotechnology, Huazhong Agricultural University
- 2003.9 – 2007.6: PhD, Institute of Microbiology, Chinese Academy of Sciences
Publications
- From solo to duet, intersections of natural product assembly with self-resistance, Linrui Wu, Qian Zhang, Zixin Deng, Yi Yu, 2022
- Aminoacyl chain translocation catalysed by a type II thioesterase domain in an unusual non-ribosomal peptide synthetase, Shan Wang, William D G Brittain, Qian Zhang, Zhou Lu, Ming Him Tong, Kewen Wu, Kwaku Kyeremeh, Matthew Jenner, Yi Yu, Steven L Cobb, Hai Deng, 2022
- Two Cryptic Self-Resistance Mechanisms in Streptomyces tenebrarius Reveal Insights into the Biosynthesis of Apramycin, Qian Zhang, Hao-Tian Chi, Linrui Wu, Zixin Deng, Yi Yu, 2021
- Two putative parallel pathways for naringenin biosynthesis in Epimedium wushanense, Yating Liu, Linrui Wu, Zixin Deng, Yi Yu, 2021
- Bacterial pathogens: threat or treat (a review on bioactive natural products from bacterial pathogens), Fleurdeliz Maglangit, Yi Yu, Hai Deng, 2021
- The biosynthetic pathway of the benzoxazole in nataxazole proceeds via an unstable ester and has synthetic utility, Haigang Song, Cong Rao, Zixin Deng, Yi Yu, James Naismith, 2020
- Three putative DNA replication/repair elements encoding genes confer self-resistance to distamycin in Streptomyces netropsis, Lie Ma, Siyao Sun, Ziyu Yuan, Zixin Deng, Yi Yu, 2019
- Enzymatic reconstitution and biosynthetic investigation of the bacterial carbazole neocarazostatin A, Yating Liu, Li Su, Qing Fang, Jioji Tabudravu, Xiaohui Yang, Kirstie Rickaby, Laurent Trembleau, Kwaku Kyeremeh, Zixin Deng, Hai Deng, Yi Yu, 2019
- Overproduction of gentamicin B in industrial strain Micromonospora echinospora CCTCC M 2018898 by cloning of the missing genes genR and genS, Yingying Chang, Baozhong Chai, Yunkun Ding, Min He, Linghui Zheng, Yun Teng, Zixin Deng, Yi Yu, Tiangang Liu, 2019
- In vitro reconstitution of the biosynthetic pathway of 3-hydroxypicolinic acid, Yun X, Zhang Q, Lv M, Deng H, Deng Z, Yu Y, 2019
- Biosynthesis of the nosiheptide indole side ring centers on a cryptic carrier protein NosJ, Ding W., Ji W., Wu Y., Wu R., Liu W., Ma X., Zhang W., Xu P., Deng Z., Tang B., Yu Y., Zhang Q, 2017
- Parallel pathways in the biosynthesis of aminoglycoside antibiotics, Yu Y., Zhang Q., Deng Z, 2017
- Dissection of the neocarazostatin A C4 alkyl side chain biosynthesis by in vitro reconstitution, Su Li, Zhang R, Kyeremeh K, Deng Z, Deng H, Yu Y, 2017
- The Catalytic Mechanism of the Class C Radical S-Adenosylmethionine Methyltransferase NosN, Ding W, Li Y, Zhao J, Ji X, Mo T, Qianzhu H, Tu T, Deng Z, Yu Y, Chen F, Zhang Q, 2017
- Nucleoside-linked shunt products in the reaction catalyzed by the class C radical S-adenosylmethionine methyltransferase NosN, Ding W, Wu Y, Ji X, Qianzhu H, Chen F, Deng Z, Yu Y, Zhang Q, 2017
- A ThDP-dependent enzymatic carboligation reaction involved in Neocarazostatin A tricyclic carbazole formation, Su Li, Lv Meinan, Kyeremeh Kwaku, Deng Zixin, Deng Hai, Yu Yi, 2016
- Characterization of a C3 Deoxygenation Pathway Reveals a Key Branch Point in Aminoglycoside Biosynthesis, Lv M, Ji X, Zhao J, Li Y, Zhang C, Su L, Ding W, Deng Z, Yu Yi, Zhang Q, 2016
- Biosynthesis of neocarazostatin A reveals the sequential carbazole prenylation and hydroxylation in the tailoring steps, Huang S, Elsayed S, Lv M, Tabudravu J, Rateb M, Gyampoh R, Kyeremyh K, Ebel R, Jaspars M, Deng Z, Yu Yi, Deng H, 2015
- Characterization of the biosynthetic gene cluster for benzoxazole antibiotics A33853 reveals unusual assembly logic, Lv Meinan, Zhao Junfeng, Deng Zixin, Yu Yi, 2015
- Discovery of a Single Monooxygenase that Catalyzes Carbamate Formation and Ring Contraction in the Biosynthesis of the Legonmycins, Huang S, Tabudravu J, Elsayed SS, Travert J, Peace D, Tong MH, Kyeremeh K, Kelly SM, Trembleau L, Ebel R, Jaspars M, Yu Yi, Deng H, 2015
- Identification and characterization of the biosynthetic gene cluster of thiolutin, a tumor angiogenesis inhibitor, in Saccharothrix algeriensis NRRL B-24137, Huang S, Tong MH, Qin Z, Deng Z, Deng H, Yu Y, 2015
- Metabolic flux analysis of the halophilic archaeon Haladaptatus paucihalophilus, Liu G, Zhang M, Mo T, He L, Zhang W, Yu Y, Zhang Q, Ding W, 2015
- Identification of a fluorometabolite from Streptomyces sp. MA37: (2R3S4S)-5-fluoro-2,3,4-tri-hydroxypentanoic acid, Long Ma, Axel Bartholome, Ming Him Tong, Zhiwei Qin, Yi Yu, Thomas Shepherd, Kwaku Kyeremeh, Hai Deng, David O'Hagan, 2015
- Mining of the pyrrolamide antibiotics analogs in Streptomyces netropsis reveals the amidohydrolase-dependent 'iterative strategy' underlying the pyrrole polymerization, Hao C.L., Huang S., Deng Z.X., Zhao C.M., Yu Y, 2014
- Disruption of a Methyltransferase Gene in Actinomycin G Gene Cluster in Streptomyces iakyrus Increases the Production of Phenazinomycin, Qin Zhiwei, Wang Xiaoling, Rateb Mostafa, Ass'ad Lina, Jaspars Marcel, Deng Zixin, Yu Yi, Deng Hai, 2014
- Fluoroacetate biosynthesis from the marine-derived bacterium Streptomyces xinghaiensis NRRL B-24674, Sheng Huang, Long Ma, Ming Him Tong, Yi Yu, David O'Hagan, Hai Deng, 2014
- Photoautotrophic production
Awards
- 2007: Second Prize, Natural Science Award, Ministry of Education
- 2015-2016: Outstanding Contribution Award, Medical Department, Wuhan University
- 2016-2017: Zhu Yubi Award, Medical Department, Wuhan University
- 2016: Top Ten Teachers, Wuhan University (10th Edition)
- 2018: Third Prize, Hubei Province Higher Education Teaching Achievement Award
- 2019: Excellent Poster Award, Excellent Paper Award, and First Prize for Innovation Achievement, World University Student Pharmaceutical Forum
- 2020: Undergraduate Teaching Performance Award, Wuhan University
