1996.9 – 2002.6: Bachelor and Master of Biotechnology, Huazhong Agricultural University
2003.9 – 2007.6: PhD, Institute of Microbiology, Chinese Academy of Sciences
2007.7 – 2009.6: Lecturer, Department of Biological Engineering, School of Life Sciences and Technology, Shanghai Jiao Tong University
2007.3 – 2009.6: Collaborative Research, Shanghai Institute of Organic Chemistry
2009.7 – 2010.6: Lecturer, College of Life Science and Technology, Huazhong Agricultural University
2012.8 – 2013.8: Visiting Scholar, Washington University in Saint Louis, USA
2010.7 – Present: Professor, Doctoral Supervisor, Wuhan University School of Pharmaceutical Sciences
2018.1 – 2018.12: Senior Visiting Scholar, University of Oxford, UK
2007: Second Prize, Natural Science Award, Ministry of Education
2015-2016: Outstanding Contribution Award, Medical Department, Wuhan University
2016-2017: Zhu Yubi Award, Medical Department, Wuhan University
2016: Top Ten Teachers, Wuhan University (10th Edition)
2018: Third Prize, Hubei Province Higher Education Teaching Achievement Award
2019: Excellent Poster Award, Excellent Paper Award, and First Prize for Innovation Achievement, World University Student Pharmaceutical Forum
2020: Undergraduate Teaching Performance Award, Wuhan University
Research
Chemical Biology and Synthetic Biology of Medicinal Plant Natural Products
From solo to duet, intersections of natural product assembly with self-resistance, Linrui Wu, Qian Zhang, Zixin Deng, Yi Yu, 2022
Aminoacyl chain translocation catalysed by a type II thioesterase domain in an unusual non-ribosomal peptide synthetase, Shan Wang, William D G Brittain, Qian Zhang, Zhou Lu, Ming Him Tong, Kewen Wu, Kwaku Kyeremeh, Matthew Jenner, Yi Yu, Steven L Cobb, Hai Deng, 2022
Two Cryptic Self-Resistance Mechanisms in Streptomyces tenebrarius Reveal Insights into the Biosynthesis of Apramycin, Qian Zhang, Hao-Tian Chi, Linrui Wu, Zixin Deng, Yi Yu, 2021
Two putative parallel pathways for naringenin biosynthesis in Epimedium wushanense, Yating Liu, Linrui Wu, Zixin Deng, Yi Yu, 2021
Bacterial pathogens: threat or treat (a review on bioactive natural products from bacterial pathogens), Fleurdeliz Maglangit, Yi Yu, Hai Deng, 2021
The biosynthetic pathway of the benzoxazole in nataxazole proceeds via an unstable ester and has synthetic utility, Haigang Song, Cong Rao, Zixin Deng, Yi Yu, James Naismith, 2020
Three putative DNA replication/repair elements encoding genes confer self-resistance to distamycin in Streptomyces netropsis, Lie Ma, Siyao Sun, Ziyu Yuan, Zixin Deng, Yi Yu, 2019
Enzymatic reconstitution and biosynthetic investigation of the bacterial carbazole neocarazostatin A, Yating Liu, Li Su, Qing Fang, Jioji Tabudravu, Xiaohui Yang, Kirstie Rickaby, Laurent Trembleau, Kwaku Kyeremeh, Zixin Deng, Hai Deng, Yi Yu, 2019
Overproduction of gentamicin B in industrial strain Micromonospora echinospora CCTCC M 2018898 by cloning of the missing genes genR and genS, Yingying Chang, Baozhong Chai, Yunkun Ding, Min He, Linghui Zheng, Yun Teng, Zixin Deng, Yi Yu, Tiangang Liu, 2019
In vitro reconstitution of the biosynthetic pathway of 3-hydroxypicolinic acid, Yun X, Zhang Q, Lv M, Deng H, Deng Z, Yu Y, 2019
Biosynthesis of the nosiheptide indole side ring centers on a cryptic carrier protein NosJ, Ding W., Ji W., Wu Y., Wu R., Liu W., Ma X., Zhang W., Xu P., Deng Z., Tang B., Yu Y., Zhang Q, 2017
Parallel pathways in the biosynthesis of aminoglycoside antibiotics, Yu Y., Zhang Q., Deng Z, 2017
Dissection of the neocarazostatin A C4 alkyl side chain biosynthesis by in vitro reconstitution, Su Li, Zhang R, Kyeremeh K, Deng Z, Deng H, Yu Y, 2017
The Catalytic Mechanism of the Class C Radical S-Adenosylmethionine Methyltransferase NosN, Ding W, Li Y, Zhao J, Ji X, Mo T, Qianzhu H, Tu T, Deng Z, Yu Y, Chen F, Zhang Q, 2017
Nucleoside-linked shunt products in the reaction catalyzed by the class C radical S-adenosylmethionine methyltransferase NosN, Ding W, Wu Y, Ji X, Qianzhu H, Chen F, Deng Z, Yu Y, Zhang Q, 2017
A ThDP-dependent enzymatic carboligation reaction involved in Neocarazostatin A tricyclic carbazole formation, Su Li, Lv Meinan, Kyeremeh Kwaku, Deng Zixin, Deng Hai, Yu Yi, 2016
Characterization of a C3 Deoxygenation Pathway Reveals a Key Branch Point in Aminoglycoside Biosynthesis, Lv M, Ji X, Zhao J, Li Y, Zhang C, Su L, Ding W, Deng Z, Yu Yi, Zhang Q, 2016
Biosynthesis of neocarazostatin A reveals the sequential carbazole prenylation and hydroxylation in the tailoring steps, Huang S, Elsayed S, Lv M, Tabudravu J, Rateb M, Gyampoh R, Kyeremyh K, Ebel R, Jaspars M, Deng Z, Yu Yi, Deng H, 2015
Characterization of the biosynthetic gene cluster for benzoxazole antibiotics A33853 reveals unusual assembly logic, Lv Meinan, Zhao Junfeng, Deng Zixin, Yu Yi, 2015
Discovery of a Single Monooxygenase that Catalyzes Carbamate Formation and Ring Contraction in the Biosynthesis of the Legonmycins, Huang S, Tabudravu J, Elsayed SS, Travert J, Peace D, Tong MH, Kyeremeh K, Kelly SM, Trembleau L, Ebel R, Jaspars M, Yu Yi, Deng H, 2015
Identification and characterization of the biosynthetic gene cluster of thiolutin, a tumor angiogenesis inhibitor, in Saccharothrix algeriensis NRRL B-24137, Huang S, Tong MH, Qin Z, Deng Z, Deng H, Yu Y, 2015
Metabolic flux analysis of the halophilic archaeon Haladaptatus paucihalophilus, Liu G, Zhang M, Mo T, He L, Zhang W, Yu Y, Zhang Q, Ding W, 2015
Identification of a fluorometabolite from Streptomyces sp. MA37: (2R3S4S)-5-fluoro-2,3,4-tri-hydroxypentanoic acid, Long Ma, Axel Bartholome, Ming Him Tong, Zhiwei Qin, Yi Yu, Thomas Shepherd, Kwaku Kyeremeh, Hai Deng, David O'Hagan, 2015
Mining of the pyrrolamide antibiotics analogs in Streptomyces netropsis reveals the amidohydrolase-dependent 'iterative strategy' underlying the pyrrole polymerization, Hao C.L., Huang S., Deng Z.X., Zhao C.M., Yu Y, 2014
Disruption of a Methyltransferase Gene in Actinomycin G Gene Cluster in Streptomyces iakyrus Increases the Production of Phenazinomycin, Qin Zhiwei, Wang Xiaoling, Rateb Mostafa, Ass'ad Lina, Jaspars Marcel, Deng Zixin, Yu Yi, Deng Hai, 2014
Fluoroacetate biosynthesis from the marine-derived bacterium Streptomyces xinghaiensis NRRL B-24674, Sheng Huang, Long Ma, Ming Him Tong, Yi Yu, David O'Hagan, Hai Deng, 2014
Photoautotrophic production
Keywords
Chemical BiologySynthetic BiologyMedicinal PlantsNatural ProductsDrug DevelopmentMetabolic EngineeringGene EngineeringBiosynthesisMicrobial SourcesHerbal Medicine
