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Fan Zhang
Medical School
Wuhan University
Hubei
Language: Chinese, English
Antibacterial
Lead Compounds
Microbial Sources
Resistance
Marine Microbiology
Omics Technologies
Natural Products
Biosynthesis
Structural Modification
Structure-Activity Relationship
Areas of Focus
- Development of lead compounds from microbial sources against resistant bacteria
- Research on marine microbial active natural metabolic products using omics technologies
- Establishment of new methods for complex natural product structure identification
- Study of biosynthetic pathways of highly active natural products
- Structural modification and structure-activity relationship studies of highly active natural products
Work Experience
- 2021.7 to present - Wuhan University, Professor, Doctoral Supervisor
- 2015.5-2021.5 - University of Wisconsin-Madison, School of Pharmacy, Assistant Scientist
- 2014.5-2015.5 - University of Wisconsin-Madison, School of Pharmacy, Postdoctoral Researcher
- 2013.4-2014.4 - University of Manitoba, Department of Chemistry, Postdoctoral Researcher
- 2012.7-2013.3 - Institute of Microbiology, Chinese Academy of Sciences, Assistant Researcher
Academic Background & Achievements
- 2007-2012 PhD: Institute of Microbiology, Chinese Academy of Sciences
- 2003-2007 Bachelor: College of Pharmacy, Jilin University
Publications
- A marine microbiome antifungal targets urgent-threat drug-resistant fungi, Zhang, F.; Zhao, M.; Braun, D. R.; Ericksen, S. S.; Piotrowski, J. S.; Nelson, J.; Peng, J.; Ananiev, G. E.; Chanana, S.; Barns, K.; Fossen, J.; Sanchez, H.; Chevrette, M. G.; Guzei, I. A., Zhao, C.; Guo, L.; Tang, W.; Currie, C. R.; Rajski, S. R.; Audhya, A.; Andes, D. R.*; Bugni, T. S.*, 2020
- Turbinmicin inhibits Candida biofilm growth by disrupting fungal vesicle-mediated trafficking, Zhao, M.; Zhang, F.; Zarnowski, R.; Barns, K.; Jones, R. Fossen, J.; Sanchez, H.; Rajski, S. R.; Audhya, A.; Bugni, T. S.*; Andes, D. R.*, 2021
- MS-derived isotopic fine structure reveals forazoline A as a thioketone-containing marine-derived natural product, Zhang, F.; Wyche, T. P.; Zhu, Y.; Braun, D. R.; Yan, J. –X.; Chanana, S.; Ge, Y.; Guzei, I. A.; Chevrette, M. G.; Currie, C. R.;, Thomas, M. G.; Rajski, S. R.; Bugni, T. S.*, 2020
- Phallusialides A-E, pyrrole-derived alkaloids discovered from a marine-derived Micromonospora sp. bacterium using MS-based metabolomics approaches, Zhang, F.; Braun, D. R.; Chanana, S.; Rajski, S. R.; Bugni, T. S.*, 2019
- Enhypyrazinones A and B, pyrazinone natural products from a marine-derived myxobacterium Enhygromyxa sp., Zhang, F.; Braun, D. R.; Ananiev, G. E.; Hoffmann, F. M.; Tsai, I. W.; Rajski, S. R.; Bugni, T. S.*, 2019
- Biemamides A-E, inhibitors of the TGF-β pathway that block the epithelial to mesenchymal transition, Zhang, F.; Braun, D. R.; Ananiev, G. E.; Hoffmann, F. M.; Tsai, I. W.; Rajski, S. R.; Bugni, T. S.*, 2018
- Thalassosamide, a siderophore discovered from the marine-derived bacterium Thalassospira profundimaris, Zhang, F.; Barns, K.; Hoffmann, F. M.; Braun, D. R.; Andes, D. R.; Bugni, T. S.*, 2017
- Application of 3D NMR for structure determination of peptide natural products, Zhang, F.; Adnani, N.; Vazquez-Rivera, E.; Braun, D. R.; Tonelli, M.; Andes, D. R.; Bugni, T. S.*, 2015
- Neoectrolide A, a new oxaphenalenone spiroketal from the fungus Neonectria sp., Ren, J.; Zhang, F.; Liu, X.; Li, L.; Liu, G.; Liu, X.; Che, Y.*, 2012
- A thiopyranchromenone and other chromone derivatives from an endolichenic fungus, Preussia africana, Zhang, F.; Li, L.; Niu, S.; Si, Y.; Guo, L.; Jiang, X.; Che, Y.*, 2012
- Isolation, antimicrobial activity, and absolute configuration of the furylidene tetronic acid core of pestalotic acids A–G, Zhang, F.; Ding, G.; Li, L.; Cai, X.; Si, Y.; Guo, L.; Che, Y.*, 2012
- Pestaloquinols A and B, isoprenylated epoxyquinols from Pestalotiopsis sp., Ding, G.; Zhang, F.; Chen, H.; Guo, L.; Zou, Z.; Che, Y.*, 2011
- Allenyl and allkynyl phenyl ethers from the endolichenic fungus Neurospora terricola, Zhang, F.; Liu, S.; Lu, X.; Guo, L.; Zhang, H.; Che, Y.*, 2009
- A community resource for paired genomic and metabolomic data mining, Schorn, M. A.; Stefan, V.; [et al, including Zhang, F.], 2021
- Structural and biosynthetic analysis of the fabrubactins, unusual siderophores from Agrobacterium fabrum strain C58, Vinnik, V.; Zhang, F.; Park, H.; Cook, T.; Throckmorton, K.; Pfleger, B.; Bugni, T.; Thomas, M.*, 2021
- hcapca: Automated Hierarchical Clustering and Principal Component Analysis of large metabolomic datasets in R, Chanana, S.; Thomas, C. S.; Zhang, F.; Rajski, S. R.; Bugni T. S.*, 2020
- The antimicrobial potential of Streptomyces from insect microbiomes, Chevrette, M. G.; Carlson, C. M.; Ortega, H. E.; Thomas, C.; Ananiev, G. E.; Barns, K. J.; Book, A. J.; Cagnazzo, J.; Carlos, C.; Flanigan, W.; Grubbs, K. J.; Horn, H. A.; Hoffmann, F. M.; Klassen, J. L.; Knack, J. J.; Lewin, G. R.; McDonald, B. R.; Muller, L.; Melo, W. G. P.; Pinto-Tomás, A. A.; Schmitz, A.; Wendt-Pienkowski, E.; Wildman, S.; Zhao, M.; Zhang, F.; Bugni, T. S.; Andes, D. R.; Pupo, M. T.; Currie C. R.*, 2019
- Coculture of marine invertebrate-associated bacteria and interdisciplinary technologies enable biosynthesis and discovery of a new antibiotic, keyicin, Adnani, N.; Chevrette, M. G.; Adibhatla, S. N.; Zhang, F.; Yu, Q.; Braun, D. R.; Nelson, J.; Simpkins, S. W.; McDonald, B. R.; Myers, C. L.; Piotrowski, J. S.; Thompson, C. J.; Currie, C. R.; Li, L.; Rajski, S. R.; Bugni, T. S.*, 2017
- Identification of the first diphenyl ether gene cluster for pestheic acid biosynthesis in plant endophyte Pestalotiopsis fici, Xu, X.; Liu, L.; Zhang, F.; Wang, W.; Li, J.; Guo, L.; Che, Y.*; Liu, G.*, 2014
- A spiro[chroman-3,7'-isochromene]- 4,6'(8H')-dione from the Cordyceps-Colonizing fungus Fimetariella sp., Li, E.; Zhang, F.; Niu, S.; Liu, X.; Liu, G.; Che, Y.*, 2012
