Professor | Fan Zhang | Asia Growth Partners

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Name	Fan Zhang
Contact Information	fzhang83@whu.edu.cn
Language ability	Chinese, English
Province	Hubei

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Name

Fan Zhang

Contact Information

fzhang83@whu.edu.cn

Language ability

Chinese, English

Province

Hubei

University/Lab Affiliation and Title	Wuhan University
Faculty	Medical School
Academic Background & Achievements	2007-2012 PhD: Institute of Microbiology, Chinese Academy of Sciences 2003-2007 Bachelor: College of Pharmacy, Jilin University
Work Experience	2021.7 to present - Wuhan University, Professor, Doctoral Supervisor 2015.5-2021.5 - University of Wisconsin-Madison, School of Pharmacy, Assistant Scientist 2014.5-2015.5 - University of Wisconsin-Madison, School of Pharmacy, Postdoctoral Researcher 2013.4-2014.4 - University of Manitoba, Department of Chemistry, Postdoctoral Researcher 2012.7-2013.3 - Institute of Microbiology, Chinese Academy of Sciences, Assistant Researcher

University/Lab Affiliation and Title

Wuhan University

Faculty

Medical School

Academic Background & Achievements

2007-2012 PhD: Institute of Microbiology, Chinese Academy of Sciences
2003-2007 Bachelor: College of Pharmacy, Jilin University

Work Experience

2021.7 to present - Wuhan University, Professor, Doctoral Supervisor
2015.5-2021.5 - University of Wisconsin-Madison, School of Pharmacy, Assistant Scientist
2014.5-2015.5 - University of Wisconsin-Madison, School of Pharmacy, Postdoctoral Researcher
2013.4-2014.4 - University of Manitoba, Department of Chemistry, Postdoctoral Researcher
2012.7-2013.3 - Institute of Microbiology, Chinese Academy of Sciences, Assistant Researcher

Areas of Focus	Development of lead compounds from microbial sources against resistant bacteria Research on marine microbial active natural metabolic products using omics technologies Establishment of new methods for complex natural product structure identification Study of biosynthetic pathways of highly active natural products Structural modification and structure-activity relationship studies of highly active natural products
Publications	A marine microbiome antifungal targets urgent-threat drug-resistant fungi, Zhang, F.; Zhao, M.; Braun, D. R.; Ericksen, S. S.; Piotrowski, J. S.; Nelson, J.; Peng, J.; Ananiev, G. E.; Chanana, S.; Barns, K.; Fossen, J.; Sanchez, H.; Chevrette, M. G.; Guzei, I. A., Zhao, C.; Guo, L.; Tang, W.; Currie, C. R.; Rajski, S. R.; Audhya, A.; Andes, D. R.; Bugni, T. S., 2020 Turbinmicin inhibits Candida biofilm growth by disrupting fungal vesicle-mediated trafficking, Zhao, M.; Zhang, F.; Zarnowski, R.; Barns, K.; Jones, R. Fossen, J.; Sanchez, H.; Rajski, S. R.; Audhya, A.; Bugni, T. S.; Andes, D. R., 2021 MS-derived isotopic fine structure reveals forazoline A as a thioketone-containing marine-derived natural product, Zhang, F.; Wyche, T. P.; Zhu, Y.; Braun, D. R.; Yan, J. –X.; Chanana, S.; Ge, Y.; Guzei, I. A.; Chevrette, M. G.; Currie, C. R.;, Thomas, M. G.; Rajski, S. R.; Bugni, T. S., 2020 Phallusialides A-E, pyrrole-derived alkaloids discovered from a marine-derived Micromonospora sp. bacterium using MS-based metabolomics approaches, Zhang, F.; Braun, D. R.; Chanana, S.; Rajski, S. R.; Bugni, T. S., 2019 Enhypyrazinones A and B, pyrazinone natural products from a marine-derived myxobacterium Enhygromyxa sp., Zhang, F.; Braun, D. R.; Ananiev, G. E.; Hoffmann, F. M.; Tsai, I. W.; Rajski, S. R.; Bugni, T. S., 2019 Biemamides A-E, inhibitors of the TGF-β pathway that block the epithelial to mesenchymal transition, Zhang, F.; Braun, D. R.; Ananiev, G. E.; Hoffmann, F. M.; Tsai, I. W.; Rajski, S. R.; Bugni, T. S., 2018 Thalassosamide, a siderophore discovered from the marine-derived bacterium Thalassospira profundimaris, Zhang, F.; Barns, K.; Hoffmann, F. M.; Braun, D. R.; Andes, D. R.; Bugni, T. S., 2017 Application of 3D NMR for structure determination of peptide natural products, Zhang, F.; Adnani, N.; Vazquez-Rivera, E.; Braun, D. R.; Tonelli, M.; Andes, D. R.; Bugni, T. S., 2015 Neoectrolide A, a new oxaphenalenone spiroketal from the fungus Neonectria sp., Ren, J.; Zhang, F.; Liu, X.; Li, L.; Liu, G.; Liu, X.; Che, Y., 2012 A thiopyranchromenone and other chromone derivatives from an endolichenic fungus, Preussia africana, Zhang, F.; Li, L.; Niu, S.; Si, Y.; Guo, L.; Jiang, X.; Che, Y., 2012 Isolation, antimicrobial activity, and absolute configuration of the furylidene tetronic acid core of pestalotic acids A–G, Zhang, F.; Ding, G.; Li, L.; Cai, X.; Si, Y.; Guo, L.; Che, Y., 2012 Pestaloquinols A and B, isoprenylated epoxyquinols from Pestalotiopsis sp., Ding, G.; Zhang, F.; Chen, H.; Guo, L.; Zou, Z.; Che, Y., 2011 Allenyl and allkynyl phenyl ethers from the endolichenic fungus Neurospora terricola, Zhang, F.; Liu, S.; Lu, X.; Guo, L.; Zhang, H.; Che, Y., 2009 A community resource for paired genomic and metabolomic data mining, Schorn, M. A.; Stefan, V.; [et al, including Zhang, F.], 2021 Structural and biosynthetic analysis of the fabrubactins, unusual siderophores from Agrobacterium fabrum strain C58, Vinnik, V.; Zhang, F.; Park, H.; Cook, T.; Throckmorton, K.; Pfleger, B.; Bugni, T.; Thomas, M., 2021 hcapca: Automated Hierarchical Clustering and Principal Component Analysis of large metabolomic datasets in R, Chanana, S.; Thomas, C. S.; Zhang, F.; Rajski, S. R.; Bugni T. S., 2020 The antimicrobial potential of Streptomyces from insect microbiomes, Chevrette, M. G.; Carlson, C. M.; Ortega, H. E.; Thomas, C.; Ananiev, G. E.; Barns, K. J.; Book, A. J.; Cagnazzo, J.; Carlos, C.; Flanigan, W.; Grubbs, K. J.; Horn, H. A.; Hoffmann, F. M.; Klassen, J. L.; Knack, J. J.; Lewin, G. R.; McDonald, B. R.; Muller, L.; Melo, W. G. P.; Pinto-Tomás, A. A.; Schmitz, A.; Wendt-Pienkowski, E.; Wildman, S.; Zhao, M.; Zhang, F.; Bugni, T. S.; Andes, D. R.; Pupo, M. T.; Currie C. R., 2019 Coculture of marine invertebrate-associated bacteria and interdisciplinary technologies enable biosynthesis and discovery of a new antibiotic, keyicin, Adnani, N.; Chevrette, M. G.; Adibhatla, S. N.; Zhang, F.; Yu, Q.; Braun, D. R.; Nelson, J.; Simpkins, S. W.; McDonald, B. R.; Myers, C. L.; Piotrowski, J. S.; Thompson, C. J.; Currie, C. R.; Li, L.; Rajski, S. R.; Bugni, T. S., 2017 Identification of the first diphenyl ether gene cluster for pestheic acid biosynthesis in plant endophyte Pestalotiopsis fici, Xu, X.; Liu, L.; Zhang, F.; Wang, W.; Li, J.; Guo, L.; Che, Y.; Liu, G., 2014 A spiro[chroman-3,7'-isochromene]- 4,6'(8H')-dione from the Cordyceps-Colonizing fungus Fimetariella sp., Li, E.; Zhang, F.; Niu, S.; Liu, X.; Liu, G.; Che, Y., 2012

Areas of Focus

Development of lead compounds from microbial sources against resistant bacteria
Research on marine microbial active natural metabolic products using omics technologies
Establishment of new methods for complex natural product structure identification
Study of biosynthetic pathways of highly active natural products
Structural modification and structure-activity relationship studies of highly active natural products

Publications

A marine microbiome antifungal targets urgent-threat drug-resistant fungi, Zhang, F.; Zhao, M.; Braun, D. R.; Ericksen, S. S.; Piotrowski, J. S.; Nelson, J.; Peng, J.; Ananiev, G. E.; Chanana, S.; Barns, K.; Fossen, J.; Sanchez, H.; Chevrette, M. G.; Guzei, I. A., Zhao, C.; Guo, L.; Tang, W.; Currie, C. R.; Rajski, S. R.; Audhya, A.; Andes, D. R.*; Bugni, T. S.*, 2020
Turbinmicin inhibits Candida biofilm growth by disrupting fungal vesicle-mediated trafficking, Zhao, M.; Zhang, F.; Zarnowski, R.; Barns, K.; Jones, R. Fossen, J.; Sanchez, H.; Rajski, S. R.; Audhya, A.; Bugni, T. S.*; Andes, D. R.*, 2021
MS-derived isotopic fine structure reveals forazoline A as a thioketone-containing marine-derived natural product, Zhang, F.; Wyche, T. P.; Zhu, Y.; Braun, D. R.; Yan, J. –X.; Chanana, S.; Ge, Y.; Guzei, I. A.; Chevrette, M. G.; Currie, C. R.;, Thomas, M. G.; Rajski, S. R.; Bugni, T. S.*, 2020
Phallusialides A-E, pyrrole-derived alkaloids discovered from a marine-derived Micromonospora sp. bacterium using MS-based metabolomics approaches, Zhang, F.; Braun, D. R.; Chanana, S.; Rajski, S. R.; Bugni, T. S.*, 2019
Enhypyrazinones A and B, pyrazinone natural products from a marine-derived myxobacterium Enhygromyxa sp., Zhang, F.; Braun, D. R.; Ananiev, G. E.; Hoffmann, F. M.; Tsai, I. W.; Rajski, S. R.; Bugni, T. S.*, 2019
Biemamides A-E, inhibitors of the TGF-β pathway that block the epithelial to mesenchymal transition, Zhang, F.; Braun, D. R.; Ananiev, G. E.; Hoffmann, F. M.; Tsai, I. W.; Rajski, S. R.; Bugni, T. S.*, 2018
Thalassosamide, a siderophore discovered from the marine-derived bacterium Thalassospira profundimaris, Zhang, F.; Barns, K.; Hoffmann, F. M.; Braun, D. R.; Andes, D. R.; Bugni, T. S.*, 2017
Application of 3D NMR for structure determination of peptide natural products, Zhang, F.; Adnani, N.; Vazquez-Rivera, E.; Braun, D. R.; Tonelli, M.; Andes, D. R.; Bugni, T. S.*, 2015
Neoectrolide A, a new oxaphenalenone spiroketal from the fungus Neonectria sp., Ren, J.; Zhang, F.; Liu, X.; Li, L.; Liu, G.; Liu, X.; Che, Y.*, 2012
A thiopyranchromenone and other chromone derivatives from an endolichenic fungus, Preussia africana, Zhang, F.; Li, L.; Niu, S.; Si, Y.; Guo, L.; Jiang, X.; Che, Y.*, 2012
Isolation, antimicrobial activity, and absolute configuration of the furylidene tetronic acid core of pestalotic acids A–G, Zhang, F.; Ding, G.; Li, L.; Cai, X.; Si, Y.; Guo, L.; Che, Y.*, 2012
Pestaloquinols A and B, isoprenylated epoxyquinols from Pestalotiopsis sp., Ding, G.; Zhang, F.; Chen, H.; Guo, L.; Zou, Z.; Che, Y.*, 2011
Allenyl and allkynyl phenyl ethers from the endolichenic fungus Neurospora terricola, Zhang, F.; Liu, S.; Lu, X.; Guo, L.; Zhang, H.; Che, Y.*, 2009
A community resource for paired genomic and metabolomic data mining, Schorn, M. A.; Stefan, V.; [et al, including Zhang, F.], 2021
Structural and biosynthetic analysis of the fabrubactins, unusual siderophores from Agrobacterium fabrum strain C58, Vinnik, V.; Zhang, F.; Park, H.; Cook, T.; Throckmorton, K.; Pfleger, B.; Bugni, T.; Thomas, M.*, 2021
hcapca: Automated Hierarchical Clustering and Principal Component Analysis of large metabolomic datasets in R, Chanana, S.; Thomas, C. S.; Zhang, F.; Rajski, S. R.; Bugni T. S.*, 2020
The antimicrobial potential of Streptomyces from insect microbiomes, Chevrette, M. G.; Carlson, C. M.; Ortega, H. E.; Thomas, C.; Ananiev, G. E.; Barns, K. J.; Book, A. J.; Cagnazzo, J.; Carlos, C.; Flanigan, W.; Grubbs, K. J.; Horn, H. A.; Hoffmann, F. M.; Klassen, J. L.; Knack, J. J.; Lewin, G. R.; McDonald, B. R.; Muller, L.; Melo, W. G. P.; Pinto-Tomás, A. A.; Schmitz, A.; Wendt-Pienkowski, E.; Wildman, S.; Zhao, M.; Zhang, F.; Bugni, T. S.; Andes, D. R.; Pupo, M. T.; Currie C. R.*, 2019
Coculture of marine invertebrate-associated bacteria and interdisciplinary technologies enable biosynthesis and discovery of a new antibiotic, keyicin, Adnani, N.; Chevrette, M. G.; Adibhatla, S. N.; Zhang, F.; Yu, Q.; Braun, D. R.; Nelson, J.; Simpkins, S. W.; McDonald, B. R.; Myers, C. L.; Piotrowski, J. S.; Thompson, C. J.; Currie, C. R.; Li, L.; Rajski, S. R.; Bugni, T. S.*, 2017
Identification of the first diphenyl ether gene cluster for pestheic acid biosynthesis in plant endophyte Pestalotiopsis fici, Xu, X.; Liu, L.; Zhang, F.; Wang, W.; Li, J.; Guo, L.; Che, Y.*; Liu, G.*, 2014
A spiro[chroman-3,7'-isochromene]- 4,6'(8H')-dione from the Cordyceps-Colonizing fungus Fimetariella sp., Li, E.; Zhang, F.; Niu, S.; Liu, X.; Liu, G.; Che, Y.*, 2012

Antibacterial Lead Compounds Microbial Sources Resistance Marine Microbiology Omics Technologies Natural Products Biosynthesis Structural Modification Structure-Activity Relationship

You-Sheng Cai - Wuhan University

Li Lu - Wuhan University

Yuhui Sun - Wuhan University

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